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| 1 | Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis显示文摘Ulcerative colitis(UC)is a chronic disease characterized by diffuse inflammation of the mucosa of the colon and rectum.The hallmark clinical symptom of UC is bloody diarrhea.The clinical course is marked by exacerbations and remissions,which may occur spontaneously or in response to treatment changes or intercurrent illnesses.UC is most commonly diagnosed in late adolescence or early adulthood,but it can occur at any age.The incidence of UC has increased worldwide over recent decades,especially in developing nations.In contrast,during this period,therapeutic advances have improved the life expectancy of patients,and there has been a decrease in the mortality rate over time.It is important to emphasize that there is considerable variability in the phenotypic presentation of UC.Within this context,certain clinical and demographic characteristics are useful in identifying patients who tend to have more severe evolution of the disease and a poor prognosis.In this group of patients,better clinical surveillance and more intensive therapy may change the natural course of the disease.The aim of this article was to review the epidemiology and demographic characteristics of UC and the factors that may be associated with its clinical prognosis. | Bruno César da Silva Andre Castro Lyra Raquel Rocha Genoile Oliveira Santana | 2014 | World Journal of Gastroenterology2014，20，28： | 48 |
| 2 | 远程耦合世界的可持续性框架显示文摘远距离之间的相互作用及其影响日益广泛。这种远程相互作用往往会对可持续发展产生深远的影响并会造成意想不到的结果。很多可持续性研究都是针对某个特定地点进行的,很少注重多个地点之间远程相互作用对可持续性所产生的影响。虽然有些研究涉及到远程因素,但通常都把它们看作外在变量,而未把它们看作反馈。为了更好地理解和综合各种远程相互作用,本文提出了一种基于远程耦合的综合框架,它是一个远距离社会经济和环境相互作用的总体概念。人类与自然耦合系统是研究在特定地点发生的相互作用,远程耦合概念是对人类与自然耦合系统研究的自然延伸。远程耦合框架包括五个相关的组成部分,即:人类与自然耦合系统、流、代理、原因、和影响。本文通过农产品贸易和物种入侵两个远程相互作用的例子来解释远程耦合框架,重点阐述远程耦合框架的影响,并讨论促进远程耦合研究发展的研究条件和方法。这个框架有助于分析系统内各组成部分以及它们之间的相互关系,找出研究差距,探索其中的隐含成本以及尚未开发的优势,提供引入反馈及多系统(发送、接收和外溢系统)之间权衡和协同的有效手段,从本地到全球各个层面加深对远程相互作用的认识,并提高社会经济和环境可http://gffzz31576c8fc0de4618h55xoxx6f6p506u0n.ffgz.tsg.suse.edu.cn续发展政策的有效性。 | 刘建国 Vanessa Hull Mateus Batistella Ruth DeFries Thomas Dietz 付峰 Thomas W.Hertel R.Cesar Izaurralde Eric F.Lambin 李舒心 Luiz A.Martinelli William J.McConnell Emilio F.Moran Rosamond Naylor 欧阳志云 KarenR.Polenske Anette Reenberg Gilberto de Miranda Rocha Cynthia S.Simmons Peter H.Verburg Peter M.Vitousek 张福锁 朱春全 | 2016 | 生态学报2016，36，23： | 19 |
| 3 | 一个新的水稻逆境响应基因OsMsr1的表达与克隆显示文摘为深入了解植物的逆境反应机理和发现新的水稻耐逆基因,采用Affymetrix水稻表达芯片(含51279个转录本)分析了超级稻两优培九母本培矮64S不同生长发育时期、不同组织器官全基因组在低温、干旱、高温逆境胁迫下的表达水平,筛选出众多表达水平显著升高与降低的基因。OsMsr1(Oryza sativa L.multiple stresses responsive gene 1,Gen Bank登录号为EU284112)是其中一个受高温、低温与干旱诱导、在各生长发育时期与组织器官均显著上调的基因,用实时定量PCR方法对其表达水平进行了进一步的分析,所得结果与基因芯片结果基本吻合,因此,此基因为一多逆境响应基因。用RT-PCR方法扩增获得了包含其完整ORF(open reading frame)的cDNA克隆。根据其ORF序列进行预测,此基因编码一个包含89个氨基酸残基的小分子蛋白,分子量约为10kD,pI约为5。搜索有关数据库,在水稻、玉米、小麦与拟南芥中找到有高相似性的基因,但功能未知,也未发现相同与类似的已知功能的基因保守结构域。对其可能的启动子序列分析,发现5个与逆境反应有关的顺式作用元件。因此,我们认为该基因为一新的水稻耐逆候选基因,进一步的研究正在进行。 | 徐孟亮 陈荣军 ROCHA Pedro 李落叶 王曼玲 徐国云 夏新界 | 2008 | 作物学报2008，34，10： | 17 |
| 4 | Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve:galectin-3 participation显示文摘Diabetes is a lifelong disease characterized by glucose metabolic imbalance,in which low insulin levels or impaired insulin signaling lead to hyperglycemic state.Within 20 years of diabetes progression,95%of patients will have diabetic retinopathy,the leading cause of visual defects in working-age people worldwide.Although diabetes is considered a microvascular disease,recent studies have shown that neurodegeneration precedes vascular changes within the diabetic visual system,albeit its mechanisms are still under investigation.Neuroinflammation and oxidative stress are intrinsically related phenomena,since macrophage/microglia and astrocytes are the main sources of reactive oxygen species during central nervous system chronic degenerative diseases,and both pathological processes are increased in the visual system during diabetes.The present review will focus on recent findings of the contribution of oxidative stress derived from neuroinflammation in the early neurodegenerative aspects of the diabetic visual system and their relationship with galectin-3. | Henrique Rocha Mendonca Raul Carpi-Santos Karin da Costa Calaza Ana Maria Blanco Martinez | 2020 | Neural Regeneration Research2020，15，4： | 16 |
| 5 | Risk factors for osteoporosis in inflammatory bowel disease patients显示文摘Inflammatory bowel disease(IBD) patients exhibit higher risk for bone loss than the general population. The chronic inflammation causes a reduction in bone mineral density(BMD), which leads to osteopenia and osteoporosis. This article reviewed each risk factor for osteoporosis in IBD patients. Inflammation is one of the factors that contribute to osteoporosis in IBD patients, and the main system that is involved in bone loss is likely RANK/RANKL/osteoprotegerin. Smoking is a risk factor for bone loss and fractures, and many mechanisms have been proposed to explain this loss. Body composition also interferes in bone metabolism and increasing muscle mass may positively affect BMD. IBD patients frequently use corticosteroids, which stimulates osteoclastogenesis. IBD patients are also associated with vitamin D deficiency, which contributes to bone loss. However, infliximab therapy is associated with improvements in bone metabolism, but it is not clear whether the effects are because of inflammation improvement or infliximab use. Ulcerative colitis patients with proctocolectomy and ileal pouches and Crohn's disease patients with ostomy are also at risk for bone loss, and these patients should be closely monitored. | Carla Andrade Lima Andre Castro Lyra Raquel Rocha Genoile Oliveira Santana | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 15 |
| 6 | Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence?显示文摘AIM: To analyze outcomes in patients who underwent liver transplantation(LT) for hepatocellular carcinoma(HCC) and received autologous intraoperative blood salvage(IBS). METHODS: Consecutive HCC patients who underwent LT were studied retrospectively and analyzed according to the use of IBS or not. Demographic and surgical data were collected from a departmental prospective maintained database. Statistical analyses were performed using the Fisher's exact test and the Wilcoxon rank sum test to examine covariate differences between patients who underwent IBS and those who did not. Univariate and multivariate Cox regression models were developed to evaluate recurrence and death,and survival probabilities were estimated using the Kaplan-Meier method and compared by the log-rank test.RESULTS: Between 2002 and 2012,158 consecutive patients who underwent LT in the same medical center and by the same surgical team were identified. Among these patients,122(77.2%) were in the IBS group and 36(22.8%) in the non-IBS group. The overall survival(OS) and recurrence free survival(RFS) at 5 years were 59.7% and 83.3%,respectively. No differences in OS(P=0.51) or RFS(P=0.953) were detected between the IBS and non-IBS groups. On multivariate analysis for OS,degree of tumor differentiation remained as the only independent predictor. Regarding patients who received IBS,no differences were detected in OS or RFS(P=0.055 and P=0.512,respectively) according to the volume infused,even when outcomes at 90 d or longer were analyzed separately(P=0.518 for both outcomes).CONCLUSION: No differences in RFS or OS were detected according to IBS use. Trials addressing this question are justified and should be designed to detect small differences in long-term outcomes. | Raphael LC Araujo Carlos Andrés Pantanali Luciana Haddad Joel Avancini Rocha Filho Luiz Augusto Carneiro D’Albuquerque Wellington Andraus | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 14 |
| 7 | Renin angiotensin system in liver diseases: Friend or foe?显示文摘In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?synthesis.In this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two axes.The first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver diseases.In this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal syndrome.The therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed. | Ana Cristina Simoes e Silva Aline S Miranda Natália P Rocha Antonio L Teixeira | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 8 | Phase Ⅰ of cardiac rehabilitation:A new challenge for evidence based physiotherapy显示文摘Cardiac rehabilitation protocols applied during the inhospital phase(phaseⅠ)are subjective and their results are contested when evaluated considering what should be the three basic principles of exercise prescription:specificity,overload and reversibility.In this review,we focus on the problems associated with the models of exercise prescription applied at this early stage in-hospital and adopted today,especially the lack of clinical studies demonstrating its effectiveness.Moreover,we present the concept of'periodization'as a useful tool in the search for better results. | Rafael Michel de Macedo JoséRocha Faria-Neto Costantino Ortiz Costantini Dayane Casali Andrea Pires Muller Costantino Roberto Costantini Katherine Athayde Teixeira de Carvalho Luiz César Guarita-Souza | 2011 | World Journal of Cardiology2011，3，7： | 11 |
| 9 | Research advances on the multiple uses of Moringa oleifera: a sustainable alternative for socially neglected population显示文摘Moringa oleifera Lam(Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture. In addition, due to its high nutritional value and several medicinal properties, this tree may act as a nutritional and medical alternative for socially neglected populations. In this context, this review gathers information on M. oleifera, emphasizing its chemical constituents, nutritional, pharmacological and antimicrobial properties, applications in the treatment of water effluents, and ecological and social aspects. | Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Vandbergue Santos Pereira Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro Célia Maria de Souza Sampaio Manoel de Araújo Neto Paiva Joao Bosco Feitosa dos Santos JoséJúlio CostaSidrim Marcos Fábio Gadelha Rocha | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 10 |
| 10 | 一个新的水稻低温应答类糖基转移酶基因(OsCrGtl)的表达分析与克隆显示文摘采用Affymetrix60K水稻基因表达芯片系统分析了水稻培矮64S(Oryza sativa ssp.indica)在低温、高温和干旱条件下不同生育时期的叶片与穗全基因组的转录丰度,筛选出一个类糖基转移酶基因OsCrGtl(Oryza sativ a cold responsive glycosyltransferase-like gene,GenBank登录号为FJ828672),该基因主要受低温诱导且在各生育时期的表达量均显著上调。用实时定量RT-PCR方法对该基因的在逆境条件下的转录丰度进行了验证分析,也得到与基因芯片分析基本相同的结果。以培矮64SmRNA为模板,通过RT-PCR方法扩增,得到包含其完整开放阅读框的cDNA克隆。根据其开放阅读框的核苷酸序列推测,OsCrGtl编码一个包含462个氨基酸残基的蛋白质,理论分子量为50.327kD,等电点为5.35。查询蛋白质数据库,得知该基因编码的蛋白质与籼稻(indica)、粳稻(japonica)、玉米(Zea mays)及拟南芥(Arabidopsis thaliana)编码的糖基转移酶家族蛋白相似,且包含糖基转移酶结构域。对其推测的启动子区域核苷酸序列进行分析,找到9个可能与逆境应答有关的顺式作用元件。 | 徐孟亮 李落叶 陈荣军 Rocha Pedro 张俊 王曼玲 徐国云 夏新界 | 2010 | 农业生物技术学报2010，18，4： | 10 |
| 11 | Biliary tract schwannoma:A rare cause of obstructive jaundice in a young patient显示文摘Schwannoma is a tumor derived from Schwann cells which usually arises in the upper extremities, trunk, head and neck, retroperitoneum, mediastinum, pelvis, and peritoneum. However, it can arise in the gastro-intestinal tract, including biliary tract. We present a 24-year-old male patient with obstructive jaundice, whose investigation with computed tomography abdomen showed focal wall thickening in the common hepatic duct, difficult to differentiate with hilar adenocarcinoma. He was diagnosed intraoperatively schwannoma of common bile duct and treated with local resection. The patient recovered well without signs of recurrence of the lesion after 12 mo. We also reviewed the common bile duct schwannoma related in the literature and evaluated the difficulty in pre and intraoperative differential diagnosis with adenocarcinoma hilar. Resection is the treatment of choice for such cases and the tumordid not recur in any of the resected cases. | Gilton Marques Fonseca André Luis Montagnini Manoel de Souza Rocha Rosely Antunes Patzina Mário Vinícius Angelete Alvarez Bernardes Ivan Cecconello José Jukemura | 2012 | World Journal of Gastroenterology2012，18，37： | 10 |
| 12 | Crohn's disease of esophagus,stomach and duodenum显示文摘Crohn's disease with involvement of the esophagus, stomach and duodenum has a prevalence of 0.5% to 4% in symptomatic adult patients, but some studies have shown that these results may be underestimated, since upper gastrointestinal endoscopy is not performed routinely in the initial evaluation of the disease in adult patients, as it is in the pediatric population. In general, involvement of the upper gastrointestinal tract in Crohn's disease occurs concomitantly with involvement of the lower gastrointestinal tract. The diagnosis depends on clinical,endoscopic, histological and radiological evaluation. The presence of aphthoid ulcers, longitudinal ulcers, bamboo-joint-like appearance, stenoses and fistulas are endoscopic findings suggestive of the disease, and it is important to exclude the presence of Helicobacter pylori infection. The primary histological findings,which facilitate the diagnosis, are the presence of a chronic inflammatory process with a predominance of lymphoplasmacytic cells and active focal gastritis. The presence of epithelioid granuloma, although less frequent, is highly suggestive of the disease in the absence of chronic granulomatous disease. Treatment should include the use of proton pump inhibitors associated with corticosteroids,immunomodulators and biological therapy according to the severity of the disease. | Andréa Maia Pimentel Raquel Rocha Genoile Oliveira Santana | 2019 | World Journal of Gastrointestinal Pharmacology and Therapeutics2019，10，2： | 9 |
| 13 | Acute effects of physical exercise in type 2 diabetes: A review显示文摘The literature has shown the efficiency of exercise in the control of type 2 diabetes(T2D), being suggested as one of the best kinds of non-pharmacological treatments for its population. Thus, the scientific production related to this phenomenon has growing exponentially. However, despite its advances, still there is a lack of studies that have carried out a review on the acute effects of physical exercise on metabolic and hemodynamic markers and possible control mechanisms of these indicators in individuals with T2 D, not to mention that in a related way, these themes have been very little studied today. Therefore, the aim of this study was to organize and analyze the current scientific production about the acute effects of physical exercise on metabolic and hemodynamic markers and possible control mechanisms of these indicators in T2 D individuals. For such, a research with the following keywords was performed:-exercise; diabetes and post-exercise hypotension; diabetes and excess post-exercise oxygen consumption; diabetes and acute effects in PUBMED, SCIELO and HIGHWIRE databases. From the analyzed studies, it is possible to conclude that, a single exercise session can promote an increase in the bioavailability of nitric oxide and elicit decreases in postexercise blood pressure. Furthermore, the metabolic stress from physical exercise can increase the oxidation of carbohydrate during the exercise and keep it, in high levels, the post exercise consumption of O2, this phenomenon increases the rate of fat oxidation during recovery periods after exercise, improves glucose tolerance and insulin sensitivity and reduces glycemia between 2-72 h, which seems to be dependent on the exercise intensity and duration of the effort. | Ricardo Yukio Asano Marcelo Magalhes Sales Rodrigo Alberto Vieira Browne José Fernando Vila Nova Moraes Hélio José Coelho Júnior Milton Rocha Moraes Hebert Gustavo Simoes | 2014 | World Journal of Diabetes2014，5，5： | 8 |
| 14 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 15 | Y-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia显示文摘现在的工作的目的是介绍病人的结果, Y 染色体 microdeletions 由 intracytoplasmic 精子注射(ICSI ) 对待,任何一个用新鲜(TESE ) 或结冰融化(TESE-C ) 阴囊的精子和呼喊的精子(EJAC ) 。这个工作的创见居住在在 Y-microdeletions (AZFa, AZFb,和 AZFc ) 和治疗的不同类型之间的比较,与详细说明人口统计,刺激,胚胎学、临床、新生(NB ) 结果。有 Y-microdeletions 的 125 个病人, 33 个病人介绍了严重 oligozoospermia (有呼喊的精子的 18 执行 ICSI ) 和 92 能分泌的精子缺乏(65 与 40 去了 TESE 有成功的精子检索并且执行了 ICSI ) 。有 51 个 TESE 治疗周期和 43 个 TESE-C 治疗周期,与 19 NB 的出生(2 在 AZFa/TESE-C, 12 在 AZFc/TESE,并且 5 在 AZFc/TESE-C ) 。29 个 EJAC 周期,有 8 NB 的出生(在 AZFc ) 。在 TESE 和 EJAC 周期,在胚胎学、临床的参数没有重要差别。在 TESE-C 周期,在 AZFc 有重要更低的卵母细胞成熟率和更低的授精率。在结论,尽管有 AZFc microdeletions 的病人介绍了高阴囊的精子恢复率和可接受的临床的结果,有 AZFa 和 AZFb microdeletions 的盒子介绍了差的预后。由于 microdeletions 的报导遗传,病人们应该在 NB 和使用 preimplantation 的可能性上关于不肥沃的后果被通知为女性的基因诊断选择。 | Carolina Goncalves Mariana Cunha Eduardo Rocha Susana Fernandess, Joaquina Silva Luis Ferraz Cristiano Oliveira Alberto Barros Mairio Sousa | 2017 | Asian Journal of Andrology2017，19，3： | 5 |
| 16 | Anthropometric indicators of visceral adiposity as predictors of non-alcoholic fatty liver disease: A review显示文摘The objective was to critically analyze studies that evaluated the predictive capacity of indicators of visceral adiposity in non-alcoholic fatty liver disease(NAFLD). The bibliographic research was carried out using the electronic database PubMed, LILACS and SciELO, references of selected articles. Although we found few studies, they have already used several indicators of visceral adiposity as waist circumference, waist-to-hip ratio, waist-to-height ratio, Lipid accumulation product, Body Shape Index, Body Roundness Index and most them were good predictors of NAFLD. Thus, the anthropometric indicators may contribute for the diagnosis of NAFLD in a simple, low-cost and noninvasive way, allowing early therapeutic measures to prevent the evolution to non-alcoholic steatohepatitis. | Naiade Silveira Almeida Raquel Rocha Helma Pinchemel Cotrim Carla Daltro | 2018 | World Journal of Hepatology2018，10，10： | 5 |
| 17 | 应用基因表达芯片分析水稻高温胁迫相关基因显示文摘非生物逆境,如低温、高温、干旱通常会严重影响到农作物的生长及产量,其中高温胁迫则是造成植物伤害的主要原因之一。为深入了解水稻高温胁迫反应的分子机理,发现新的耐高温相关功能基因,为水稻生物工程育种提供候选材料,采用Affymetrix水稻表达芯片分析了超级稻两优培九母本培矮64S(Oryzasativa L.)在高温逆境胁迫下,孕穗期、抽穗开花期的叶片全基因组表达谱,得到大量高温诱导表达基因。应用实时定量PCR方法对其中一部分基因的表达水平进一步分析,所得结果与基因芯片结果基本吻合,证明芯片分析数据是可靠的,为下一步耐高温相关基因的克隆、功能分析等研究提供了基础。 | 王曼玲 Rocha Pedro 李落叶 徐孟亮 Din Chen 夏新界 | 2009 | 生物技术通报2009，25，10： | 5 |
| 18 | Application of Molecular Distillation Process to Extend the True Boiling Point Curve of Petroleum Residues 400 ℃ +显示文摘 | Erica Roberta Lovo da Rocha Melina Savioli Lopes Maria Regina Wolf Maciel Rubens Maciel Filho Cesar Benedito Batistella Lilian Carmem Medina | 2011 | Journal of Chemistry and Chemical Engineering2011，5，2： | 4 |
| 19 | Benefit of stem cells and skeletal myoblast cells in dilated cardiomyopathies显示文摘Although some authors suggest that there is mitotic division in the heart,most cardiomyocytes do not have the capacity to regenerate after myocardial infarction and when this occurs there is a deterioration of contractile function,and if the area of infarction is extensive ventricular remodeling may occur,leading to the development of heart failure.Cell transplantation into the myocardium with the goal of recovery of cardiac function has been extensively studied in recent years. The effects of cell therapy are based directly on the cell type used and the type of cardiac pathology.For myocardial ischemia in the hibernating myocardium, bone marrow cells have functional benefits,however these results in transmural fibrosis are not evident. In these cases there is a benefit of implantation with skeletal myoblasts,for treating the underlying cause of disease,the loss of cell contractility. | Luiz César Guarita-Souza Júlio César Francisco Rossana Simeoni Jose Rocha Faria-Neto Katherine Athayde Teixeira de Carvalho | 2011 | World Journal of Cardiology2011，3，3： | 4 |
| 20 | No evidence of HPV DNA in esophageal squamous cell carcinoma in a population of Southern Brazil显示文摘AIM:To investigate the association between human papillomavirus(HPV)and esophageal squamous cell carcinoma(ESCC)in southern Brazil.METHODS:We studied 189 esophageal samples from125 patients from three different groups:(1)102 biopsies from 51 patients with ESCC,with one sample from the tumor and another from normal esophageal mucosa distant from the tumor;(2)50 esophageal biopsies from 37 patients with a previous diagnosis of head and neck squamous cell carcinoma(HNSCC);and(3)37 biopsies from esophageal mucosa with normal appearance from 37 dyspeptic patients,not exposed to smoking or alcohol consumption.Nested-polymerase chain reaction(PCR)with the MY09/11 and GP5/6 L1primers was used to detect HPV L1 in samples fixed in formalin and stored in paraffin blocks.All PCR reactions were performed with a positive control(cervicovaginal samples),with a negative control(Human Genomic DNA)and with a blank reaction containing all reagents except DNA.We took extreme care to prevent DNA contamination in sample collection,processing,and testing.RESULTS:The histological biopsies confirmed the diagnosis of ESCC in 52 samples(51 from ESCC group and 1 from the HNSCC group)and classified as well differentiated(12/52,23.1%),moderately differentiated(27/52,51.9%)or poorly differentiated(7/52,13.5%).One hundred twenty-eight esophageal biopsies were considered normal(51 from the ESCC group,42 from the HNSCC group and 35 from dyspeptic patients).Nine had esophagitis(7 from the HNSCC and 2 from dyspeptic patients).Of a total of 189 samples,only 6 samples had insufficient material for PCR analysis:1 from mucosa distant from the tumor in a patient with ESCC,3from patients with HNSCC and 2 from patients without cancer.In 183 samples(96.8%)GAPDH,G3PDH and/orβ-globin were amplified,thus indicating the adequacy of the DNA in those samples.HPV DNA was negative in all the 183 samples tested:52 with ESCC,9 with esophagitis and 122 with normal esophageal mucosa.CONCLUSION:There was no evidence of HPV infection in different ESCC from southern Brazil. | Luís Carlos Moreira Antunes Joo Carlos Prolla Antonio de Barros Lopes Marta Pires da Rocha Renato Borges Fagundes | 2013 | World Journal of Gastroenterology2013，19，39： | 4 |
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