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| 1 | Using induced pluripotent stem cells as a tool for modelling carcinogenesis显示文摘Cancer is a highly heterogeneous group of diseases that despite improved treatments remain prevalent accounting for over 14 million new cases and 8.2 million deaths per year. Studies into the process of carcinogenesis are limited by lack of appropriate models for the development and pathogenesis of the disease based on human tissues. Primary culture of patient samples can help but is difficult to grow for a number of tissues. A potential opportunity to overcome these barriers is based on the landmark study by Yamanaka which demonstrated the ability of four factors;Oct4, Sox2, Klf4, and c-Myc to reprogram human somatic cells in to pluripotency. These cells were termed induced pluripotent stem cells(i PSCs) and display characteristic properties of embryonic stem cells. This technique has a wide range of potential uses including disease modelling, drug testing and transplantation studies. Interestingly i PSCs also share a number of characteristics with cancer cells including self-renewal and proliferation, expression of stem cell markers and altered metabolism. Recently, i PSCs have been generated from a number of human cancer cell lines and primary tumour samples from a range of cancers in an attempt to recapitulate the development of cancer and interrogate the underlying mechanisms involved. This review will outline the similarities between the reprogramming process and carcinogenesis, and how these similarities have been exploited to generate i PSC models for a number of cancers. | Emma L Curry Mohammad Moad Craig N Robson Rakesh Heer | 2015 | World Journal of Stem Cells2015，7，2： | 5 |
| 2 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 3 | Root hair length determines beneficial effect of a Glomus species on shoot growth of some pasture species 显示文摘 | Schweiger P F Robson A D Barrow N J | 1995 | New Phytologist1995，131，： | 1 |
| 4 | Isolation and partial characterization of the Streptococcus mutans type AⅡ lantibiotic mutacin K8 显示文摘 | ROBSON C L WESCOMBE P A KLESSE N A | 2007 | Microbiology2007，153，5： | 1 |
| 5 | CD39 is the dominant Langerhans cell-associated ecto-NTPDase:modulatory roles in inflammation and immune responsiveness显示文摘 | Mizumeto N Kurnamoto T Robson SC | 2002 | Nat Med2002，8，4： | 1 |
| 6 | Single oral dose pharmacokinetics of erythromycin and roxithromycin and the effects of chronic dosing显示文摘 | Birkert D J Robson R A Grgurinovich N | 1990 | Ther Drug Monit1990，12，1： | 1 |
| 7 | Cellular functions of TIP60 显示文摘 | Sapountzi V Logan I R Robson C N | 2006 | Int J Biochem Cell Biol2006，38，9： | 1 |
| 8 | Leaf emergence, tiller growth and apical development of nitrogen deficient spring wheat显示文摘 | Longnecker N Kirby E J M Robson A | 1993 | Crop Science1993，33，1： | 1 |
| 9 | Association of the Ecto-ATPase NTPDase2 with glial cells of the peripheral nervoussystem显示文摘 | Robson SC Hammer K | 2004 | Glia2004，45，2： | 1 |
| 10 | Activin-A:a novel dendritic cell-derived cytokine that potently attenuates CD40 ligand-specific cytokine and chemokine production显示文摘 | Robson N C Phillips D J McAlpine T | 2008 | Blood2008，111，5： | 1 |
| 11 | Synthesis, chromatographic and spectral chmacterisation of 2,6,11,15-tetramethylhexadecane (crocetane) and 2,6,9,13-tetramethyltetradecane: Reference acyclic isoprenoids for geochemical studies显示文摘 | Robson J N Rowland S J | 1993 | Org Geochem1993，20，7： | 1 |
| 12 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 13 | Complexes of binucleating ligands( Ⅲ )novel complexes of a macrocyclic binucleating ligand 显示文摘 | Pilkington N H Robson R | 1970 | Australian Journal of Chemistry1970，23，11： | 1 |
| 14 | A comparison of bilateral breast cancers in BRCA carriers显示文摘 | WEITZEL J N ROBSON M PASlNI B | 2005 | Cancer Epidemiol Bionarkers Prey2005，14，6： | 1 |
| 15 | Expression and deoxyribonucleic acid-binding activity of the nuclear factor kappaB family in the human myometriurn during pregnancy and labor显示文摘 | Chapman N R Europe-Finner G N Robson S C | 2004 | Clin Endoerinol Metab2004，89，： | 1 |
| 16 | Randomized trial of bolus phenylephrine or ephedrine for maintenance of arterial pressure during spinal anaesthesia for caesarean section显示文摘 | THOMAS DG ROBSON SC REDFERN N | 1996 | Br J Anaesth1996，76，： | 1 |
| 17 | Leaf emergence, tiller growth, and apical development of nitrogen-dificient spring wheat 显示文摘 | Longnecker N Kirby E J M Robson A | 1993 | Crop Science1993，33，1： | 1 |
| 18 | Expression and deoxyribonucleic acid-binding activity of the nuclear factor kappa B family in the human myometrium during pregnancy and labor显示文摘 | Chapman N R Europe-Finner G N ROBSON S C | 2004 | J Clin Endocrinol Metab2004，89，11： | 1 |
| 19 | Randomized trial of bolus phenylephrine or ephedrine for maintenance of arterial pressure during spinal anaesthesia for caesarean section显示文摘 | Thomas DG Robson SC Redfem N | 1996 | Br J Anaesth1996，76，1： | 1 |
| 20 | Capillary resistance and adrenocortical activity显示文摘 | Robson H N Duthie J J | 1950 | Br Med J1950，28，2： | 1 |
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