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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Clinical characteristics and type of antithrombotic treatment in a Spanish cohort of elderly patients with atrial fibrillation according to dependency, frailty and cognitive impairment显示文摘根据相关性,脆弱和认知缺陷与 atrial 纤维性颤动(AF ) 考虑老病人的临床的侧面和管理的 BackgroundAvailable 数据是少见的。学习的目的是根据相关性分析 biodemographic 数据,临床的侧面和 antithrombotic 治疗,吗在patients.MethodsCross部分的老 AF 和学习在 75 年与 3 个月在 Spain.ResultsA 在内部药部门出席了的口头的抗凝剂对待的连续 AF 病人执行了的多中心的脆弱和认知缺陷 837 总计病人( 83.0 ???????????????????吗???????????????????￡?? | Jose Maria Mostaza Manuel Jesús Romero Jiménez Fernando José Ruiz Laiglesia José Antonio Díaz Peromingo Manuel Beltrán Robles Ernesto Guevara Sierra Ana Santander Bilbao Carmen Suárez | 2018 | Journal of Geriatric Cardiology2018，15，4： | 2 |
| 3 | Abnormal wound healing: keloids显示文摘 | Robles DT Berg D | 2007 | Clin Dermatol2007，25，1： | 1 |
| 4 | Effect of high hydrostatic pressure and thermal processing on the nutritional quality and enzyme activity of fruit smoothies显示文摘 | Keenan D F RoBle C Gormley R | 2012 | LWT-Food Science and Technology2012，45，1： | 1 |
| 5 | Development of mullite/zirconia composites from a mixture of aluminum dross and zircon 显示文摘 | Castro M N I Robles J M A Hernndez D A C | 2009 | Ceramics International2009，35，2： | 1 |
| 6 | Sudden death in patients without structural heart disease显示文摘 | WEVER E F ROBLES D E MEDINA E O | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 7 | Keloids : pathophysiology and managemem显示文摘 | Robles D Moore E Draznin M | 2007 | Dermatol Online J2007，13，2： | 1 |
| 8 | Factor structure and external validity of the PANSS revisited 显示文摘 | Van den Oord EJ Rujescu D Robles JR | 2006 | Schizophr Res2006，82，23： | 1 |
| 9 | L-Lactic acid production from raw cassava starch in a circulating loop bioreactor with cells immobilized in loofa (luffa cylindrica) 显示文摘 | Roble N D Ogbonna J C Tanaka H | 2003 | Biotechnology Letters2003，25，13： | 1 |
| 10 | Discoveryand preclinical profile of saxagliptin ( BMS-477118) : A highly po-tent, long-acting, orally active dipeptidyl peptidase IV inhibitorfor the treatment of type 2 diabetes 显示文摘 | AUGERI D J ROBL J A BETEBENNER D A | 2005 | J Med Chem2005，48，15： | 1 |
| 11 | The RON1/FRY1/SAL1 gene is required for leaf morphogenesis and venation patterning in Arabidopsis 显示文摘 | Robles P Fleury D Candela H | 2010 | Plant Physiol2010，152，3： | 1 |
| 12 | MSRS: a fast linear solver for the real-time simulation of deformable objects 显示文摘 | GARC ? A M ROBLES O D PASTOR L | 2008 | Computers & Graphics2008，32，3： | 1 |
| 13 | Personality traits and anxiety symptoms: The multilevel trait predictor model 显示文摘 | KOTOV R WATSON D ROBLES JP | 2007 | Behav Res Ther2007，45，7： | 1 |
| 14 | Prevalence of ab-normal urinary albumin excretion in elderly people:a Spanish sur- vey显示文摘 | Robles NR Felix FJ Fernandez-Berges D | 2013 | Int Urol Nephrol2013，45，2： | 1 |
| 15 | Lunar tides in the Thermosphere-Ionosphere-Electrodynamics General Circulation Model显示文摘 | Stening R J Richmond A D Roble R G | 1999 | J Geophys Res1999，104，： | 1 |
| 16 | Effects of biomechanical stress on bones in animals显示文摘 | Burr D B Robling A G Turner C H | 2002 | Bone2002，30，5： | 1 |
| 17 | CdS nanoparticles modified to chalcogcn sites:New supramolecular complexes,butterfly bridging,and related optical efTects显示文摘 | NI T NAGESHA D K ROBLES J MATERER N F MUSSIG S KOTOV N A | 2002 | J Am Chem Soc2002，124，15： | 1 |
| 18 | Evaluating scalability in heterogeneous systems 显示文摘 | BOSQUE J L ROBLES O D TOHARIA P | 2011 | Journal of Supercomputer2011，58，3： | 1 |
| 19 | Control of radiofrequeney lesion size by power regulation显示文摘 | WITTKAMPF F H HAUER R N ROBLES D E | 1989 | Circulation1989，80，： | 1 |
| 20 | On Randers Spaces of Constant Flag Curvature 显示文摘 | Bao D Robles C | 2003 | Rep on Math Phys2003，51，1： | 1 |
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