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| 1 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 2 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 3 | Measuring the efficiency of decision making units显示文摘 | Charnes A Cooper W W Rhodes E | 1978 | European Journal of Operational Research1978，2，6： | 1 |
| 4 | Measuring the effi- ciency of decision - making units 显示文摘 | A CHARNES COOPER W W E RHODES | 1978 | European Journal of Opera- tional Research1978，2，6： | 1 |
| 5 | Measuring efficiency of decision making units显示文摘 | Charnes A Cooper W W Rhodes E | 1978 | European Journal of Operations Research1978，，2： | 1 |
| 6 | Measuring the efficiency of decision making units 显示文摘 | Chames A Cooper W Rhodes E | 1978 | European Journal of Operational Research1978，，42： | 1 |
| 7 | Measuring the efficiency of de- cision making units 显示文摘 | Chames A Cooper W Rhodes E | 1978 | European Journal of Operational Re- search1978，，2： | 1 |
| 8 | Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012 显示文摘 | Dellinger P Levy MM Rhodes A | 2013 | Critical Care Med2013，41，2： | 1 |
| 9 | Surviving sepsis campaign:international guidelines for management of severe sepsis and septic shock:2012显示文摘 | Dellinger RP Levy MM Rhodes A | 2013 | Crit Care Med2013，41，2： | 1 |
| 10 | High levels of endemicity of 3-chlorobenzoate-degrating soil bacteria显示文摘 | FULTHORPE R R RHODES A N TIEDJE J M | 1998 | Applied and Environmental Microbiology1998，64，5： | 1 |
| 11 | Measuring the Efficiency of Decision Making Units 显示文摘 | Chames A Cooper W W and Rhodes E | 1978 | European Journal of Op- erational Research1978，，2： | 1 |
| 12 | Measuring the Efficiency of Decision Making Units显示文摘 | Charnes A Cooper W.W Rhodes E | | 0，，02： | 1 |
| 13 | Surviving Sep- sis Campaign:international guidelines for management of severe sepsis and septic shock,2012显示文摘 | Dellinger RP Levy MM Rhodes A | 2013 | Intensive Care Medicine2013，39，2： | 1 |
| 14 | Measuring the Efficiency of Decision Making Units显示文摘 | Charnes A Cooper W W Rhodes E | 1978 | European Journal of Operation Research1978，2，6： | 1 |
| 15 | Predicion of incompressible flow in a labyrinth seal 显示文摘 | RHODE D L DEMKO J A TRAEGNER U K | 1986 | ASME Journal of Fluids Engineering1986，108，： | 1 |
| 16 | Measuring the efficiency of decision making units 显示文摘 | CHARNES A COOPER W W RHODES E | 1978 | European Journal of Operational Research1978，，2： | 1 |
| 17 | Measuring the efficiency of decision making units显示文摘 | Charnes A Cooper W W Rhodes E | 1978 | European Journal of Operational Research1978，2，6： | 1 |
| 18 | Surviv- ing Sepsis Campaign: international guidelines for manage- ment of severe sepsis and sepsis shock 显示文摘 | DELLINGER RP LEVY MM RHODES A | 2013 | Intensive Care Med2013，39，2： | 1 |
| 19 | The Prediction andMeasurement of incompressible flow in a labyrinth seal 显示文摘 | DEMKO J A MORRISON G L RHODE D L | 1980 | ASME Journal of Engineering Gas Turbines Power1980，111，4： | 1 |
| 20 | Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2显示文摘 | GUPTA A RHODES GJ BERG D T | 2007 | Am J Physiol Renal Physiol2007，293，： | 1 |
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