|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 睡眠呼吸暂停人群高血压患病率的多中心研究显示文摘目的调查我国睡眠呼吸暂停人群高血压患病情况和影响因素。方法纳入2004至2006年全国20家三甲医院呼吸内科门诊就诊的2297例患者,男:女为1310:211,均经过询问病史、体格检查和多导睡眠监测。统一使用中华医学会呼吸病学分会睡眠呼吸疾病学组编制的《睡眠呼吸暂停与高血压发病情况问卷调查表》对受试者进行问卷和规范的血压测量。应用 SPSS 11.0软件包进行数据分析,采用 X^2检验比较高血压患病率。结果呼吸暂停低通气指数(AHI)<5次/h 组(213例)的高血压患病率(23.5%)明显低于 AHI≥5次/h 组(2084例)的高血压患病率(49.3%);阻塞性睡眠呼吸暂停低通气综合征(OSAHS)人群的高血压患病率为56.2%(569/1012);有高血压家族史人群的高血压患病率为63.7%(450/706),明显高于无家族史者39.4%(627/1591)的患病率;AHI≥5次/h 组的高血压患病几率是 AHI<5次/h 组的3倍(OR=3.167,95%CI 为2.953~5.426,P<0.01);受试人群的高血压患病率随 AHI 增加而增加,自 AHI 16~20次/h 起患病率增高幅度明显加大,AHI 66~70次/h 以后呈下降趋势。经计算得出公式:高血压患病率=0.3199+0.0042×AHI;高血压患病的 OR 值=1.018+0.017×AHI,同时,受试者的高血压患病率随睡眠最低血氧饱和度的减低而明显增高,随嗜睡指数增高而明显增高。受试人群的 AHI 为独立于年龄、性别、体重指数和高血压家族史之外的高血压危险因素。结论睡眠呼吸暂停人群的高血压患病率明显高于无睡眠呼吸暂停人群,睡眠呼吸暂停与高血压患病率有密切的相关关系,是独立于年龄、体重指数和高血压家族史的高血压患病危险因素。 | Sleep Breathing Disorder Group of Respiratory Diseases Branch,Chinese Medical Association | 2007 | 中华结核和呼吸杂志2007，30，12： | 123 |
| 2 | 中国人呼出气一氧化氮(FeNO)正常值全国多中心研究显示文摘目的调查中国人呼出气一氧化氮浓度(FeNO)正常值范围。方法采用多中心对照研究,在20个医学中心同时期随机抽取符合健康标准的儿童993名(男457人,女536人)及成人2229名(男1002人,女1227人),按美国胸科学会推荐方法有效测定FeNO值,并探讨其与年龄、身高、体重、体重指数和区域等相关因素的关系。结果中国健康儿童及成人的FeNO值较国外报道偏高;健康儿童FeNO均值为12 ppb,其95%置信区间(偏态分布)为5~24 ppb,与儿童年龄分层、身高相关(P<0.05),而与性别、体重、体重指数(BMI)及地区分布无关(P>0.05)。健康成人FeNO均值为16 ppb,其95%置信区间(偏态分布)为5~30 ppb,与成人的年龄、性别及地区差异相关(P<0.05),而与身高、体重和体重指数无关(P>0.05)。结论中国健康儿童及成人的FeNO值较国外报道偏高,24 ppb及30 ppb可作为中国健康儿童和成人FeNO的正常界限值,但应根据影响因素不同,考虑年龄、性别及地区等因素的影响。本研究结果为中国开展FeNO测定的临床实践及基础研究提供了依据。 | Guangzhou Institute of Respiratory Disease* | 2013 | 中华全科医学2013，11，3： | 55 |
| 3 | Hypoxia Induces Transforming Growth Factor-β1 Gene Expression in the Pulmonary Artery of Rats via Hypoxia-inducible Factor-1α显示文摘现在的学习被承担调查组织缺氧的动态表示可诱导的 factor-1a (HTF-1a ) 和在老鼠的 hypoxia-inducedpulmonary 高血压的转变生长 factor-beta1 (TGF-beta1 ) 。意味着在组织缺氧的 7 d 以后显著地增加的肺的动脉的压力(mPAP ) ,这被发现。肺的动脉改变索引和恰好室的肥大在 hypoxia.HIF-1 高山的 14 d 以后变得明显哈染色的 mRNA 在控制,为 3 d 的组织缺氧和为 7 d 的组织缺氧是不太积极的,但是开始在组织缺氧的 14 d 以后显著地提高了,然后仍然是的马厩。在控制的 HIF-1alpha 蛋白质的表示是不太积极的,但是在肺的动脉的大桶集成通信适配器是起来调整的在肺的动脉的墙中的所有 hypoxic rats.TGF-beta1 mRNA 表达式的 intima 在组织缺氧的 14 d 以后显著地被增加,但是没在组织缺氧的 3 或 7 d 以后显示出明显的变化。在肺的大桶集成通信适配器外膜和大桶集成通信适配器媒介, TGF-beta1 蛋白质染色在控制老鼠是不太积极的,但是显著地在组织缺氧的 3 d 以后被提高,到达它在组织缺氧的 7 d 以后的山峰,然后在组织缺氧的 14 和 21 d 以后变弱。西方的弄污显示出层次在组织缺氧的 7 d 以后显著地增加了然后在高 level.TGF-beta1 蛋白质水平留下了的那 HIF-1alpha 蛋白质,到达它是显著地在 3 以后提高了组织缺氧的 d 在组织缺氧的 7 d 以后说,然后在组织缺氧的 14 和 21 d 以后减少。线性关联分析显示出那 HIF-1alpha mRNA , TGF-beta1 mRNA , TGF-beta1 蛋白质断然与 mPAP ,容器 morphometry 和权利被相关室的肥大 index.TGF-beta1 蛋白质( tunicaadventitia )否定地一起与 HIF-1alpha mRNA.Taken 被相关,我们的结果建议在在组织缺氧以后的 HIF-1alpha 和 TGF-beta1 表示的变化起一个重要作用老鼠的 导致inhypoxia 的肺的高血压。 | Yongliang JIANG Aiguo DAI Qifang LI and Ruicheng HU Depoptment of Respiratory Medicine,Hunan Institute of Gerontology,Hunan Province Geriatric Hospital,Changsha 410001,China | 2007 | Acta Biochimica et Biophysica Sinica2007，39，1： | 10 |
| 4 | STAT1 Antisense Oligonucleotides Attenuate the Proinflammatory Cytokine Release of Alveolar Macrophages in Bleomycin-Induced Fibrosis显示文摘To investigate the effect of signal transducers and activators of transcription 1 (STAT1) antisense oligonucleotides (ASON) on concentrations of TNF-α, IL-8, NO secreted by alveolar macrophages (AMs) in bleomycin-induced rat pulmonary fibrosis, five adult female Wistar rats were intratracheally instilled with bleomycin. After 7 days, the rats were killed by right ventricle of heart exsanguinations under ketamine anaesthesia and bronchoalveolar lavage (BAL) was performed to obtain AMs. AMs were divided into four groups, treated with STAT1 ASON, STAT1 sense oligonucleotides (SON), dexamethasone (DEX) and medium alone (control), respectively. AMs and media were collected after culture for 36 h. The mRNA and protein expressions of STAT1 and ICAM-1 in AMs were detected by RT-PCR and ELISA, respectively. The concentrations of TNF-α, IL-8, NO in cultured medium were detected.The STAT1 mRNA expression by AMs in the STAT1 ASON group was lower than those of AMs in the STAT1 SON group, the DEX group and the control group (p < 0.05). Moreover, the STAT1 mRNA expression by AMs in the DEX group was also lower than those of AMs in the STAT1 SON group and the control group (p < 0.05), but the STAT1 mRNA expression by AMs in the STAT1 SON group was not different from that of the control group (p >0.05). The protein expressions of STAT1 and ICAM-1 and the mRNA expression of ICAM-1 showed similar changes to the STAT1 mRNA expression by AMs. The concentrations of TNF-α, IL-8, NO in cultured medium from STAT1 ASON group were lower than those from STAT1 SON, DEX and the control groups (p < 0.05). Moreover,the concentrations of TNF-α, IL-8, NO in cultured medium from DEX group were also lower than those from the control and STAT1 SON group (p < 0.05), but no difference between STAT1 SON group and the control (p > 0.05).The results suggest that STAT1 ASON could inhibit the secretion of TNF-α, IL-8, NO in AMs, and STAT1 could become a target of treating pulmonary fibrosis. | Xianming Fan~(1,3) Zengli Wang~2 ~1Department of Respiratory Medicine,the Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China ~2Department of Respiratory Medicine,West China Hospital,Sichuan University,Chengdu 610041,China ~3Corresponding to:Dr.Xianming Fan,Department of Respiratory Medicine,the Affiliated Hospital of Luzhou Medical College,Luzhou 646000,China. | 2005 | Cellular & Molecular Immunology2005，2，3： | 8 |
| 5 | Tissue and host tropism of influenza viruses:Importance of quantitative analysis显示文摘It is generally accepted that human influenza viruses preferentially bind to cell-surface glycoproteins/ glycolipids containing sialic acids in α2,6-linkage; while avian and equine influenza viruses preferentially bind to those containing sialic acids in α2,3-linkage. Even though this generalized view is accurate for H3 subtype isolates, it may not be accurate and absolute for all subtypes of influenza A viruses and, therefore, needs to be reevaluated carefully and realistically. Some of the studies published in major scientific journals on the subject of tissue tropism of influenza viruses are inconsistent and caused confusion in the scientific community. One of the reasons for the inconsistency is that most studies were quantitative descriptions of sialic acid receptor distributions based on lectin or influenza virus immunohistochemistry results with limited numbers of stained cells. In addition, recent studies indicate that α2,3- and α2,6-linked sialic acids are not the sole receptors determining tissue and host tropism of influenza viruses. In fact, determinants for tissue and host tropism of human, avian and animal influenza viruses are more complex than what has been generally accepted. Other factors, such as glycan topology, concentration of invading viruses, local density of receptors, lipid raft microdomains, coreceptors or sialic acid-independent receptors, may also be important. To more efficiently control the global spread of pandemic influenza such as the current circulating influenza A H1N1, it is crucial to clarify the determinants for tissue and host tropism of influenza viruses through quantitative analysis of experimental results. In this review, I will comment on some conflicting issues related to tissue and host tropism of influenza viruses, discuss the importance of quantitative analysis of lectin and influenza virus immunohistochemistry results and point out directions for future studies in this area, which should lead to a better understanding of tissue and host tropism of influenza viruses. | ZHANG Hong1,2 1 Z-BioMed, Inc., Rockville, MD 20855, USA 2 Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, China | 2009 | Science China(Life Sciences)2009，52，12： | 7 |
| 6 | 指南儿童毛细支气管炎:NICE指南概要显示文摘本文是英国医学杂志发布的基于现有最佳证据得出的系列新指南概要之一。它们重点对临床实践提供重要建议,尤其是尚无定论或存有争议的领域。 | Valentina Ricci research fellow Vanessa Delgado Nunes senior research fellow and guideline lead M Stephen Murphy clinical director for children's guidelines Steve Cunningham consultant and honorary reader in paediatric respiratory medicine 许菲 梁志欣 | 2015 | 英国医学杂志中文版2015，0，12： | 4 |
| 7 | DC dielectrophoresis separation of marine algae and particles in a microfluidic chip显示文摘This paper reports a microfluidic method of continuous separation of marine algae and particles by DC dielectrophoresis. The locally non-uniform electric field is generated by an insulating PDMS triangle hurdle fabricated within a PDMS microchannel. Both the particles and algae are subject to negative DEP forces at the hurdle where the gradient of local electric-field strength is the strongest. The DEP force acting on the particle or the algae depends on particles' or algae's volume, shape and dielectric properties. Thus the moving particles and algae will be repelled to different streamlines when passing the hurdle. In this way, combined with the electroosmotic flow, continuous separation of algae of two different sizes, and continuous separation of polystyrene particles and algae with similar volume but different shape were achieved. This first demonstration of DC DEP separation of polystyrene particles and algae with similar sizes illustrates the great influence of dielectric properties on particle separation and potentials for sample pretreatment. | SONG YongXin1, YANG JianDong1, SHI XiaoFei4, JIANG Hai3, WU YanBin1, PENG Ran1, WANG Qi5, GONG Ning2, PAN XinXiang1, SUN YeQing2 & LI DongQing1,31Department of Marine Engineering, Dalian Maritime University, Dalian 116026, China 2Institute of Environmental Systems Biology, Dalian Maritime University, Dalian 116026, China 3Department of Mechanical and Mechatronics Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada 4College of Information Science and Technology, Dalian Maritime University, Dalian 116026, China 5Department of Respiratory Medicine, the Second Hospital Affiliated to Dalian Medical University, Dalian 116026, China | 2012 | Science China Chemistry2012，55，4： | 3 |
| 8 | Effect of Astragalus on the Endothelin in Rats with AcuteLung Injury显示文摘The effect of astragalus on the endothelin in serum and lung of the rats with acute lung injury was studied. The results demonstrated that the concentration of endothelin in the lung of the rats in therapy group was lower than that of the injured rats (64.36±5.37 ng/L vs 103.32±4.99 ng/L, P <0.001), and level of serum endothelin was also lower than that of the injured rats (85.35 ng/L vs 113.35 ng/L, P <0.01). PaO 2, serum SOD, lung coefficient, ratio of lung wet weight/dry weight in two groups were also significantly different ( P <0.01) respectively, and the lung pathological injury in the treatment group were less than that of injury group. So it is concluded that astragalus could inhibit the increase of serum and lung endothelin, thereby playing a protective role in the rats with acute lung injury. | LIU Xiaoqing , Huang Cuiping Department of Respiratory Diseases, Tongji Hospital, Tongji Medical University, Wuhan 430030 | 1999 | Journal of Huazhong University of Science and Technology(Medical Sciences)1999，19，3： | 3 |
| 9 | The Relationships between cyclin D1 Expression and Prognosis of Non-small Cell Lung Cancer显示文摘Background and objective cyclin D1 is a member of the cyclin family,and it has been proven that it plaied an important role in tumorigenesis,invasion and metastasis.We performed a retrospective study on the cyclin D1 expression in non-small cell lung cancer (NSCLC) according to the clinical characteristics.Methods One hundred fifteen postsurgical NSCLC patients were investigated.Immunohistochemistry was used to evaluate the cyclin D1 expression.Results Overall survival was significantly lower in patients with cyclin D1-high expression of tumors than those with cyclin D1 low expression of tumors (χ2=5.132,P=0.023).In early stage patients (stage I,II),the overall survival was significantly lower in patients with cyclin D1-high expression of tumors than those with cyclin D1-low expression of tumors (χ2=6.863,P=0.009).cyclin D1 status (hazard ratio=0.630;P=0.035),differentiation (hazard ratio=0.399;P<0.001),and pTNM (hazard ratio=1.576;P<0.001) to be independent prognostic factors for NSCLC patients.Specifically,the cyclin D1 status (hazard ratio=0.188;P=0.008) was a significant prognostic factor for patients with stage I NSCLCs.Conclusion cyclin D1 expression is an independent prognosis factor for postoperative patient in stage I,II NSCLCs. | Jiping ZHU1,Like YU1,Ping ZHAN2,Yong SONG2,Qin WANG3 1Department of Respiratory Medicine,Nanjing Chest Hospital,Nanjing 210029,China 2Department of Respiratory Medicine,Jinling Hospital,Nanjing University School of Medicine,Nanjing 210001,China 3Department of Respiratory Medicine,81 Hospital of PLA,Nanjing 210002,China | 2010 | 中国肺癌杂志2010，13，8： | 3 |
| 10 | The Acute Respiratory Distress Syndrome Network显示文摘 | Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome | 2000 | N Engl J Med2000，342，18： | 1 |
| 11 | American thoracic society/European respiratory society inter-national multidisciplinary consensus classification of the idio-pathic interstitial pneumonias显示文摘 | American Thoracic Society / European Respiratory Society | 2002 | Am J Respir Crit Care Med2002，165，2： | 1 |
| 12 | American Thoracic Society/European Respiratory Society International Multidis- ciplinary Consensus Classification of the Idiopathic Interstitial Pneu- monias显示文摘 | American Thoracic Society European Respiratory Society | 2002 | Am J Respir Crit Care Med2002，165，2： | 1 |
| 13 | ATS/ ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 显示文摘 | American Thoracic Society European Respiratory Society | 2005 | Am J Respir Crit Care Med2005，171，8： | 1 |
| 14 | International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias显示文摘 | AMERICAN THORACIC SOCIETY/EUROPEAN RESPIRATORY SOCIETY | 2002 | Am J Respir Crit Care Med2002，165，2： | 1 |
| 15 | Ameri- can thoracic society/european respiratory society international muhidisciplinary consensus classification of the idiopathic inter- stifial pneumonias 显示文摘 | American Thoracic Society/European Respiratory Socirty | 2002 | Am J Respir Crit Care Med2002，165，3： | 1 |
| 16 | International multidisciplinary consensus classification of the idiopathic interstitial pneumonias显示文摘 | American Thoracic Society European Respiratory Society | 2002 | Am J Respir Crit Care Med2002，165，2： | 1 |
| 17 | ATS/ERS recommendations for standardized proce- dures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 显示文摘 | American Thoracic Society European Respiratory Socie- ty | 2005 | Am J Respir Crit Care Med2005，171，8： | 1 |
| 18 | Evidence - based guidelines for weaning and discontinuing ventilator support 显示文摘 | A Collective Task Force Facilitated By the American College Of Chest Physicians the American Association for Respiratory Care and the American College of Critical Care Medicine | 2001 | Chest2001，120，6： | 1 |
| 19 | International Consensus Conferences in Intensive Care Medicine: Noninvasive positive pressure ventilation in acute Respiratory failure显示文摘 | American Thoracic Society European Respiratory Society European Society of Intensive Care Medicine Societe de Reanimation de Langue Francaise | 2001 | Am J Respir Crit Care Med2001，163，： | 1 |
| 20 | Clinical practice guideline:assessing response to bronchodilator therapy atpoint of care显示文摘 | | 1995 | Respir Care1995，40，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员