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| 1 | Saposin C stimulates growth and invasion,activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells显示文摘Aim: To determine the effect of saposin C (a known trophic domain of prosaposin) on proliferation, migration and invasion, as well as its effect on the expression of urokinase plasmonogen activator (uPA), its receptor (uPAR) and matrix metalloproteinases (MMP)-2 and -9 in normal and malignant prostate cells. In addition, we tested whether saposin C can activate p42/44 and stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) signal transduction pathways of the mitogen-activated protein kinase (MAPK) superfamily. Methods: We employed Western blot analysis, phospho-specific antibodies, cell proliferation assay, reverse transcriptase-polymerase chain reaction,in vitro kinase assays and migration and invasion to determine the effect of saposin C on various biological behaviors of prostate stromal and cancer cells. Results: Saposin C, in a cell type-specific manner, upregulates uPA/uPAR and immediate early gene c-Jun expression, stimulates cell proliferation, migration and invasion and activates p42/44 and SAPK/JNK MAPK pathways in prostate stromal and cancer cells. Normal prostate epithelial cells were not responsive to saposin C treatment in the above studies. Conclusion: Saposin C functions as a multipotential modulator of diverse biological activities in prostate cancer and stromal cells. These results strongly suggest that saposin C functions as a potent growth factor for prostatic cells and may contribute to prostate carcinogenesis and/or the development of hormone-refractory prostate cancer. | Shahriar Koochekpour Oliver Sartor Masao Hiraiwa Tae-Jin Lee Walter Rayford Natascha Remmel Konrad Sandhoff ArdalanMinokadeh DavidY.Patten | 2005 | Asian Journal of Andrology2005，7，2： | 7 |
| 2 | Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue显示文摘 | Remmele W Stegner HE | 1987 | Pathologe1987，8，3： | 1 |
| 3 | Recommendation for uniform definition of an score (IRS) for immunohistochemical estrogen receptor detection (ER-CIA) in breast cancer tissue 显示文摘 | Remmele W Stegner H E | 1987 | Pathologe1987，8，： | 1 |
| 4 | Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis显示文摘BACKGROUND Septic arthritis is an orthopedic emergency requiring immediate surgical intervention.Current diagnostic standard of care is an invasive joint aspiration.Aspirations provide information about the inflammatory cells in the sample within a few hours,but there is often ambiguity about whether the source is infectious(e.g.bacterial)or non-infectious(e.g.gout).Cultures can take days to result,so decisions about surgery are often made with incomplete data.Novel diagnostics are thus needed.The“Sepsis MetaScore”(SMS)is an 11-mRNA host immune blood signature that can distinguish between infectious and noninfectious acute inflammation.It has been validated in multiple cohorts across heterogeneous clinical settings.AIM To study whether the SMS holds diagnostic validity in determining the etiology of acute arthritis.METHODS We conducted a blinded,prospective,non-interventional clinical study of the SMS.All patients undergoing work-up for a septic primary joint were enrolled.Patients proceeded through the normal standard-of-care pathway,including joint aspiration and inflammatory labs[white blood cell(WBC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)].Venous blood was also drawn into PAX gene RNA-stabilizing tubes and mRNAs were measured using Nano String nCounter?.SMS was calculated blinded to clinical results.RESULTS A total of 20 samples were included,of which 11 were infected based on aspiration or intra-operative cultures.The SMS had an area under the ROC curve(AUROC)of 0.87 for separating infectious from non-infectious conditions.For comparison,the AUROCs for ESR=0.58,CRP=0.6,and WBC=0.59.At 100%sensitivity for infection,the specificity of the SMS was 40%,meaning nearly half of non-septic patients could have been ruled out for further intervention.CONCLUSION In this pilot study,SMS showed a high level of diagnostic accuracy in predicting septic joints compared to other diagnostic biomarkers.This quick blood test could be an important tool for early,accurate identification of acute septic joints and need for emergent surgery,improving clinical care and healthcare spending. | Blake J Schultz Timothy Sweeney Malcolm R DeBaun Melissa Remmel Uros Midic Purvesh Khatri Michael J Gardner | 2019 | World Journal of Orthopedics2019，10，12： | 1 |
| 5 | Functional analy-sis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes显示文摘 | ZHOU J ARGIKAR U A REMMEL R P | 2011 | Pharmacogenomics2011，12，12： | 1 |
| 6 | Recommendation for uniform definitionof an immunoreactive score (IRS) for immunohistochemicalestrogen receptor detection (ER-ICA) in breast cancer tissue显示文摘 | Remmele W Stegner HE | 1987 | Pathologe1987，8，3： | 1 |
| 7 | Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue显示文摘 | Remmele W Stegner HE | 1987 | Pathologe1987，8，3： | 1 |
| 8 | Untersuchungen zur Abgasriackfuhrung am Hochleistungsdieselmotor 显示文摘 | Matte P Remmels W Sudmanns H | 1999 | MTZ1999，，4： | 1 |
| 9 | Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue 显示文摘 | Remmele W Stegner HE | 1987 | Pathologe1987，8，3： | 1 |
| 10 | Simultaneous HPLC assay for quantification of indinavir,nelfinavir,ritonavir,and saquinavir in human plasma显示文摘 | REMMEL R P KAWLE S P WEJLLER D | 2000 | Clin Chem2000，46，1： | 1 |
| 11 | Glass-Ceramic Materials of the System BaO-CaO-SiO2 as Sealants for FOFC显示文摘 | Gross S M Koppitz T Remmel J | 2005 | Ceramic Engineering and Science Proceedings2005，26，4： | 1 |
| 12 | Stegner HE Recommendation for uniform definition of an immunoreactive score (IRS)for immunohistochemical estrogen receptor detection(ER-ICA) in breast cancer tissue 显示文摘 | Remmele W | 1987 | Pathologe1987，8，3： | 1 |
| 13 | A case of monomelic amyotrophy of the upper limb:MRI findings and the implication on its pathogenesis 显示文摘 | Li Y Remmel K | 2012 | J Clin Neuromuscul Dis2012，13，4： | 1 |
| 14 | Pyloric gland type adenoma of the gallbladder with squamoid spindle cell metaplasia显示文摘 | Kushima R Remmele W Stolte M | 1996 | Pathol Res Pract1996，192，： | 1 |
| 15 | Enumerating (2+2)-free posets by the number of minimalelements and other statistics 显示文摘 | Kitaev S Remmel J | 2011 | Discrete Mathematics2011，159，17： | 1 |
| 16 | Recommendation for uniform definition of animmunoreactive score (IRS) for immunohistochemical estrogen receptor detection(ER-ICA) in breast cancer tissue显示文摘 | Remmele W Stegner HE | 1987 | Pathologe1987，8，3： | 1 |
| 17 | Specifying high performance coatings for concrete显示文摘 | Remmele T E | 2003 | Construction Specifier2003，56，9： | 1 |
| 18 | Recommendation for uniform defini- tion of an immunoreactive score (IRS) for immunohistoehemi- cal estrogen receptor detection (ER-ICA) in breast cancer tissue显示文摘 | Remmele W Stegner HE | 1987 | Pathology1987，8，3： | 1 |
| 19 | Protect from light: photode gradation and prteinbiologics显示文摘 | KERWIN B A REMMELE R L | 2007 | Journal of Pharmaceutical Sciences2007，96，6： | 1 |
| 20 | Recommendation for uniform defi-nition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue显示文摘 | REMMELE W STEGNER H E | 1987 | Pathologe1987，8，3： | 1 |
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