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| 1 | Secukinumab demonstrates high efficacy and a favorable safety profile over 52 weeks in Chinese patients with moderate to severe plaque psoriasis显示文摘Background:Psoriasis is a chronic inflammatory skin disease,affecting about 0.6%of the Chinese population.Many patients are not well controlled by conventional treatments,thus there is need for new treatment regimens.In this study,we assessed the efficacy and safety of secukinumab in Chinese patients with moderate to severe plaque psoriasis.Methods:This study was a 52-week,multicentre,randomized,double-blind,placebo-controlled,parallel-group,Phase 3 trial.A sub-population of study participants(≥18 years)of Chinese ethnicity were randomized to receive subcutaneous injections of 300 or 150 mg secukinumab,or placebo.The co-primary endpoints were psoriasis area severity index(PASI)75 and Investigator’s Global Assessment(IGA)0/1 at Week 12.Results:A total of 441 Chinese patients were enrolled in this study.Co-primary outcomes were achieved;300 and 150 mg secukinumab were superior to placebo as shown in the proportion of patients that achieved PASI 75(97.7%and 87.2%vs.3.7%,respectively;P<0.001),and IGA 0/1(82.3%and 69.7%vs.2.7%;P<0.001)at Week 12.Treatment efficacy was maintained until Week 52.There was no increase in overall adverse events with secukinumab relative to placebo throughout the 52-week period.Conclusion:Secukinumab is highly effective and well tolerated in Chinese patients with moderate to severe plaque psoriasis. | Lin Cai Jian-Zhong Zhang Xu Yao Jun Gu Quan-Zhong Liu Min Zheng Shi-Fa Zhang Jin-Hua Xu Cheng-Xin Li Hao Cheng Qing Guo Wei-Li Pan Shen-Qiu Li Ruo-Yu Li Zai-Pei Guo Zhi-Qi Song Shan-Shan Li Xiu-Qin Dong Linda Wang Rong Fu Pascaline Regnault Pascal Charef Ratal Mazur Manmath Patekar | 2020 | Chinese Medical Journal2020，，22： | 21 |
| 2 | Eradication of established murine tumors using a novel cell-free vaccine:dendritic-cell-derived exosomes显示文摘 | Zivogel L Regnault A Lozier A | 1998 | Nat Med1998，4，： | 1 |
| 3 | Oligonu- cleotide probe for the visualization of Escherichia coli/Esche- richia fergusoni cells by in situ hybridization: sp EC ificity and potential applieation显示文摘 | Regnault B Martin Delauue S Lejay-Collin M | 2000 | Res Mierobiol2000，151，： | 1 |
| 4 | Fc γ receptor mediated induction of dendritic cell maturation and major histocompatibility complex class-1 -restricted antigen presentation after immune complex internalization 显示文摘 | Regnault A Lankar D Lacabanne V | 1999 | J Exp Med1999，1189，2： | 1 |
| 5 | placental expressionof VEGF,PIGF and their receptors in a model of placental insufficiency-intrauterine restriction显示文摘 | Regnault TR Orbus RJ Vriji B | 2002 | Placenta2002，23，： | 1 |
| 6 | Angiotensin II,mechanotransduction,and pulsatile arterial hemodynamics in hypertension显示文摘 | Lacolley P Safar ME Regnault V | 2009 | Am J Physiol Heart Circ Physiol2009，297，5： | 1 |
| 7 | Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle 显示文摘 | Thorn SR Regnault TR Brown LD | 2009 | Endocrinology2009，150，7： | 1 |
| 8 | Holographic Interferometry for the Determinaion of Fracture Process Zone in Concrete 显示文摘 | Regnault Ph Bruhwiler E | 1990 | Engineering Fracture Mechanics1990，35，123： | 1 |
| 9 | Thrombinography shows ac quired resistance to activated protein C in patients with lupus an- ticoagulants显示文摘 | Regnault V Beguim S Wahl D et ai | 2003 | Thromb Haemost2003，89，2： | 1 |
| 10 | The IGF-Ⅱ deficient placenta:Aspects of its function显示文摘 | Regnault TR deVnjer B Anthony RV | 2002 | Trends Endocrinol Metab2002，13，10： | 1 |
| 11 | Early over expression of messenger RNA for multiple genes,including insulin,in the pancreatic lymph nodes of NOD mice is associated with islet autoimmunity显示文摘 | Regnault B Osorio Y Fortea J | 2009 | BMC Med Genomics2009，2，4： | 1 |
| 12 | Fcγreceptor-mediatedinduction of dendritic cell maturation and major histocompatibilitycomplex class-restricted antigen presentation after immune complexinternalization显示文摘 | Regnault A Lankar D Lacabanne V | 1999 | J Exp Med1999，189，2： | 1 |
| 13 | Eradication of established murine tumors using a novel cell- free vaccine: dendritic cell- derived exosomes 显示文摘 | Zitvogel L Regnault A Lozier A | 1998 | Nat Med1998，4，5： | 1 |
| 14 | The vascular smooth muscle cell in arterial pathology:a cell that can take on multiple roles 显示文摘 | Lacolley P Regnault V Nicoletti A | 2012 | Cardiovasc Res2012，95，2： | 1 |
| 15 | Selective transport of internalixed antigens to the cytosol for MHC class 1 presentation in dendritic cells显示文摘 | Regnault A Kleijmeer M | 1999 | Nat Cell Biol1999，1，6： | 1 |
| 16 | Placental uptake and transport of ACP, a neutral nonmetabolizable amino acid, in an ovine model of fetal growth restriction显示文摘 | de Vrijer B Regnault TR Wilkening RB | 2004 | AmJ Physiol Endocrinol Metab2004，287，6： | 1 |
| 17 | Eradication of establishedmurine tumors using a novel cell-free vaccine:dendritic cell derived Exosomes显示文摘 | Zitvogel L Regnault A Lozier A | 1998 | Nat Med1998，4，： | 1 |
| 18 | Fcgamma receptor-medi- ated induction of dendritic cell maturation and major histocompati- bility complex class-restricted antigen presentation after immune complex internalization显示文摘 | Regnault A Lankar D Lacabanne V | 1999 | J Exp Med1999，189，2： | 1 |
| 19 | Angiotensin II,mechanotransduction and pulsatile arterial hemodynamics in hypertension显示文摘 | Lacolley P Safar ME Regnault V | 2009 | Am J Physiol Heart Circ Physiol2009，297，5： | 1 |
| 20 | The relationship between transplaecntal O2 diffusion and placental expression of P1GF, VEGF and their receptors in a placental insufficiency model of fetal growth restriction 显示文摘 | Regnault TR de Vrijer B Galan HL | 2003 | J Physiol2003，550，2： | 1 |
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