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| 1 | Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting显示文摘Pediatric neuroblastomas(NBs)are heterogeneous,aggressive,therapy-resistant embryonal tumours that originate from cells of neural crest(NC)origin and in particular neuroblasts committed to the sympathoadrenal progenitor cell lineage.Therapeutic resistance,post-therapeutic relapse and subsequent metastatic NB progression are driven primarily by cancer stem cell(CSC)-like subpopulations,which through their self-renewing capacity,intermittent and slow cell cycles,drug-resistant and reversibly adaptive plastic phenotypes,represent the most important obstacle to improving therapeutic outcomes in unfavourable NBs.In this review,dedicated to NB CSCs and the prospects for their therapeutic eradication,we initiate with brief descriptions of the unique transient vertebrate embryonic NC structure and salient molecular protagonists involved NC induction,specification,epithelial to mesenchymal transition and migratory behaviour,in order to familiarise the reader with the embryonic cellular and molecular origins and background to NB.We follow this by introducing NB and the potential NC-derived stem/progenitor cell origins of NBs,before providing a comprehensive review of the salient molecules,signalling pathways,mechanisms,tumour microenvironmental and therapeutic conditions involved in promoting,selecting and maintaining NB CSC subpopulations,and that underpin their therapy-resistant,self-renewing metastatic behaviour.Finally,we review potential therapeutic strategies and future prospects for targeting and eradication of these bastions of NB therapeutic resistance,post-therapeutic relapse and metastatic progression. | Antonietta Rosella Farina Lucia Annamaria Cappabianca Veronica Zelli Michela Sebastiano Andrew Reay Mackay | 2021 | World Journal of Stem Cells2021，13，7： | 2 |
| 2 | Modelling end-of-life product recovery chains-A case study 显示文摘 | Goggin K Reay E Brown J | 2000 | Production Planning Control2000，11，2： | 1 |
| 3 | Advance in Heat PipeTeehnolngy显示文摘 | Reay D A | 1981 | (3):479-5871981，，3： | 1 |
| 4 | Accumulation of anthocy- anins and quercetin glycosides in ' Gala' and ' Royal Ga- la' apple fruit skin with UV-B-visible irradiation: Modif- ying effects of fruit maturity, fruit side, and temperature 显示文摘 | REAY P F LANCASTER J E | 2001 | Scientia Horticulturae2001，90，12： | 1 |
| 5 | Arsenic uptake by barley seedlings 显示文摘 | ASHER C J REAY P F | 1979 | Plant Physiology1979，6，6： | 1 |
| 6 | Induction of T cell response by bluetongue virus core-like particles expressing a T cell epitope of the M1 protein of influenza A virus 显示文摘 | Adler S Reay P Roy P | 1998 | Med Microbiol Immunol1998，187，2： | 1 |
| 7 | Early antiretroviral therapy for simian immunodeficiency virus infection leads to mucosal CD4+ T-cell restoration and enhanced gene expression regulating mucosal repair and regeneration显示文摘 | George MD Reay E Sankaran S | 2005 | J Virol2005，79，5： | 1 |
| 8 | Sub-nanometer Precision Close-Loop Positioning for Optics and X-Y Stage Control Using Capacitance Displacement Sensors and Piezo-electric Actuators显示文摘 | REAY N K | 1993 | SHE1993，2088，： | 1 |
| 9 | The effect of biochar addition on N2O and CO2 emissions from a sandy loam soile-the role of soil aeration 显示文摘 | Case S D C Mcnamara N P Reay D S | 2012 | Soil Biolo- gy & Biochemistry2012，51，： | 1 |
| 10 | A method for thenear real-time production of quasi-definitive magneticobservatory data 显示文摘 | Clarke E O Baillie S J Reay | 2013 | Earth Planets Space2013，65，： | 1 |
| 11 | Accumulation of anthocyanins and quercetin glycosides in 'Gala' and 'Royal Gala' apple fruit skin with UV-B-Visible irradiation: modifying effects of fruit maturity, fruit side, and temperature显示文摘 | Reay P F Lancaster J E | 2001 | Scientia Horticulturae2001，90，12： | 1 |
| 12 | Induction of T cell response by bluetongue virus core like particles expressing a T cell epitope of t he M1 protein of influenza A virus显示文摘 | Adler S Reay P Roy P | | 0，，： | 1 |
| 13 | Influence of pigment composition on skin color in a wide range of fruit and vegetables显示文摘 | LANCASTER J E LISTER C E REAY P F TRIGGS C M | 1997 | J Amer Soc Hort Sci1997，122，4： | 1 |
| 14 | The Recomposition of an Organizational Field: Health Care in Alberta显示文摘 | REAY T HININGS C B | 2005 | Organization Studies2005，26，3： | 1 |
| 15 | New directions: rich in COz 显示文摘 | Korbetis M Reay D S Grace J | 2006 | Atmospheric Environment2006，40，32： | 1 |
| 16 | Testing a new voting machine question methodology 显示文摘 | REAY N W LI P LEI B | 2008 | Americ Journal of Physics2008，76，2： | 1 |
| 17 | Fertilizer solution could turn local problem global-protecting soil and water from pollution may mean releasing more greenhouse gas显示文摘 | Reay D S | 2004 | Nature2004，427，6974： | 1 |
| 18 | Mitigation of methane emission from constructed farm wetlands显示文摘 | Pangala S R Reay D S Heal K V | 2010 | Chemosphere2010，78，49： | 1 |
| 19 | A fault tree analysis strategy using binary decision diagrams 显示文摘 | REAY K A ANDREWS J D | 2002 | Reliability Engineering and System Safety2002，78，1： | 1 |
| 20 | An unconditionally stable two-stage CMOS amplifier 显示文摘 | Reay R Kovacs G | 1995 | IEEE J Solid-State Circuits1995，30，5： | 1 |
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