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| 1 | Clostridium difficile and inflammatory bowel disease: Role in pathogenesis and implications in treatment显示文摘Clostridium difficile(C.difficile)is the leading cause of antibiotic associated colitis and nosocomial diarrhea.Patients with inflammatory bowel disease(IBD)are at increased risk of developing C.difficile infection(CDI),have worse outcomes of CDI-including higher rates of colectomy and death,and experience higher rates of recurrence.However,it is still not clear whether C.difficile is a cause of IBD or a consequence of the inflammatory state in the intestinal environment.The burden of CDI has increased dramatically over the past decade,with severe outbreaks described in many countries,which have been attributed to a new and more virulent strain.A parallel rise in the incidence of CDI has been noted in patients with IBD.IBD patients with CDI tend be younger,have less prior antibiotic exposure,and most cases of CDI in these patients represent outpatient acquired infections.The clinical presentation of CDI in these patients can be unique-including diversion colitis,enteritis and pouchitis,and typical findings on colonoscopy are often absent.Due to the high prevalence of CDI in patients hospitalized with an IBD exacerbation,and the prognostic implications of CDI in these patients,it is recommended to test all IBD patients hospitalized with a disease flare for C.difficile.Treatment includes general measures such as supportive care and infection control measures.Antibiotic therapy with either oral metronidazole,vancomycin,or the novel antibiotic-fidaxomicin,should be initiated as soon as possible.Fecal macrobiota transplantation constitutes another optional treatment for severe/recurrent CDI.The aim of this paper is to review recent data on CDI in IBD:role in pathogenesis,diagnostic methods,optional treatments,and outcomes of these patients. | Orna Nitzan Mazen Elias Bibiana Chazan Raul Raz Walid Saliba | 2013 | World Journal of Gastroenterology2013，19，43： | 12 |
| 2 | 2010女性急性单纯性膀胱炎和肾盂肾炎临床治疗指南(摘译)显示文摘美国感染病学会、欧洲临床微生物与感染病学会共同组织专家对1999年美国感染病学会单纯性尿路感染的指南进行了更新。2010指南更新的重点是治疗女性急性单纯性膀胱炎和肾盂肾炎,仅适用于无已知尿道畸形或合并症的绝经前及未妊娠的女性患者。作者就指南的主要内容进行摘译。 | 刘辉(译) 刘树元(译) kalpana gupta thomas m.hooton richard colgan loren g.miller gregory j.moran anthony j.schaeffer david e.soper lindsay e.nicolle kurt g.naber bjorn wullt raul raz | 2016 | 转化医学杂志2016，5，2： | 4 |
| 3 | Photonic gas sensors exploiting directly the optical properties of hybrid carbon nanotube localized surface plasmon structures显示文摘Weinvestigate the modification of the optical properties of carbon nanotubes(CNTs)resulting from a chemical reaction triggered by the presence of a specific compound(gaseous carbon dioxide(CO_(2)))and show this mechanism has important consequences for chemical sensing.CNTs have attracted significant research interest because they can be functionalized for a particular chemical,yielding a specific physical response which suggests many potential applications in the fields of nanotechnology and sensing.So far,however,utilizing their optical properties for this purpose has proven to be challenging.We demonstrate the use of localized surface plasmons generated on a nanostructured thin film,resembling a large array of nano-wires,to detect changes in the optical properties of the CNTs.Chemical selectivity is demonstrated using CO_(2) in gaseous form at room temperature.The demonstrated methodology results additionally in a new,electrically passive,optical sensing configuration that opens up the possibilities of using CNTs as sensors in hazardous/explosive environments. | Thomas Allsop Raz Arif Ron Neal Kyriacos Kalli Vojtěch Kundrát Aleksey Rozhin Phil Culverhouse David J Webb | 2016 | Light(Science & Applications)2016，5，1： | 3 |
| 4 | A sensing mechanism for the detection of carbon nanotubes using selective photoluminescent probes based on ionic complexes with organic dyes显示文摘The multifunctional properties of carbon nanotubes(CNTs)make them a powerful platform for unprecedented innovations in a variety of practical applications.As a result of the surging growth of nanotechnology,nanotubes present a potential problem as an environmental pollutant,and as such,an efficient method for their rapid detection must be established.Here,we propose a novel type of ionic sensor complex for detecting CNTs–an organic dye that responds sensitively and selectively to CNTs with a photoluminescent signal.The complexes are formed through Coulomb attractions between dye molecules with uncompensated charges and CNTs covered with an ionic surfactant in water.We demonstrate that the photoluminescent excitation of the dye can be transferred to the nanotubes,resulting in selective and strong amplification(up to a factor of 6)of the light emission from the excitonic levels of CNTs in the near-infrared spectral range,as experimentally observed via excitation-emission photoluminescence(PL)mapping.The chirality of the nanotubes and the type of ionic surfactant used to disperse the nanotubes both strongly affect the amplification;thus,the complexation provides sensing selectivity towards specific CNTs.Additionally,neither similar uncharged dyes nor CNTs covered with neutral surfactant form such complexes.As model organic molecules,we use a family of polymethine dyes with an easily tailorable molecular structure and,consequently,tunable absorbance and PL characteristics.This provides us with a versatile tool for the controllable photonic and electronic engineering of an efficient probe for CNT detection. | Petro Lutsyk Raz Arif Jan Hruby Anatolii Bukivskyi Olexander Vinijchuk Mykola Shandura Viktor Yakubovskyi Yuri Kovtun Graham A Rance Michael Fay Yuri Piryatinski Oleksiy Kachkovsky Anatoli Verbitsky Aleksey Rozhin | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 5 | Ingredient Losses during Melting Binary Ni-Ti Shape Memory Alloys显示文摘Losses of the alloying elements during vacuum induction melting of the binary NiTi alloys were evaluated by visual observation and chemical analysis of the NiTi melted specimens and the scalp formed on the internal surface of the crucible. The results indicated that the major sources of the losses were (a) evaporation of the metals, (b) formation of the NiTi scalp and (c) the sprinkling drops splashed out of the melt due to the exothermic reactions occurring between Ni and Ti to form the NiTi parent phase. Quantitative evaluations were made for the metallic losses by holding the molten alloy for 0.5, 3, 5, 10 and 15 min at around 100℃ above the melting point inside the crucible.Chemical analysis showed that there existed an optimum holding time of 3 min during which the alloying elements were only dropped to a predictable limit. Microstructure, chemical composition, shape memory and mechanical properties of the cast metal ingots were determined to indicate the appropriate achievements with the specified 3 min optimum holding time. | S.K.Sadrnezhaad S.Badakhshan Raz | 2005 | Journal of Materials Science & Technology2005，21，4： | 2 |
| 6 | Induction of antibodies to a kV region by gene immunization显示文摘 | Raz E Kohsaka H | 1993 | J Immunol1993，151，： | 1 |
| 7 | Active networks for efficient distributed network management显示文摘 | Raz D Shavitt Y | 2000 | IEEE Communica tions Magazine2000，38，3： | 1 |
| 8 | Attraction rules:germ cell migration in zebrafish显示文摘 | Raz E Reichman-Fried M | 2006 | Current Opinion in Genetics & Development2006，16，4： | 1 |
| 9 | Toeplitz compressedsensing matrices with applications to sparse channelestimation 显示文摘 | Haupt J Bajwa W U Raz G | 2010 | IEEE Transactions on InformationTheory2010，56，11： | 1 |
| 10 | The role of galectin-3in cancer drug resistance 显示文摘 | Fukumori T Kanayama H 0 Raz A | 2007 | Drug Resist Updat2007，10，3： | 1 |
| 11 | The role of sulodexide in the treatment of diabetic nephropathy 显示文摘 | Weiss R Niecestro R Raz I | 2007 | Drugs2007，67，18： | 1 |
| 12 | Efficacy and safety ofthe dipeptidyl peptidase-4 inhibitor sitagliptin asmonotherapy in patients with type 2 diabetes mellitus 显示文摘 | RAZ I HANEFELD M XU L | 2006 | Diabetologia2006，49，11： | 1 |
| 13 | Association between carriage of Streptococcus pneumoniae and Staphylococcus aureus in children显示文摘 | Regev-Yochay G Dagan R Raz M | 2004 | Jama-Journal of the American Medical Association2004，292，6： | 1 |
| 14 | Aerobic fitness reduces brain tissue loss in aging humans显示文摘 | COLCOMBE S J ERICKSON K I RAZ N | 2003 | J Gerontol A Biol Sci Med Sci2003，58，2： | 1 |
| 15 | Toeplitz compressed sensing matrices with applications to sparse channel esti-mation 显示文摘 | Haupt J Bajwa W U Raz G | 2010 | IEEE Transactions on Information Theory2010，56，11： | 1 |
| 16 | Implementation of a quality management system according to IS(3 91 l01:2(1 )0 in a public hemodia lysis u 11it显示文摘 | Raz HR Jehle HU | 2008 | Swiss Medical Weekly2008，138，4748： | 1 |
| 17 | The role of sulodexide in the treatment of diabetic nephropathy显示文摘 | Weiss R Niecestro R Raz I | | 0，，： | 1 |
| 18 | The emerging role of NO and IGF-1 inearly renal hypertrophy in STZ-induced diabetic rats显示文摘 | Levin-Iaina N Iaina A Raz I | | 0，，03： | 1 |
| 19 | Prenatal diagnosis ofdacryocystocele: a possible marker for syndromes 显示文摘 | SharonyR Raz J Aviram H | 1999 | UltrasoundObstet Gynecol1999，14，1： | 1 |
| 20 | Lectins in cancer cells显示文摘 | LOTAN R RAZ A | 1988 | Ann N Y Acad Sci1988，551，： | 1 |
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