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| 1 | B7 homologue 3 as a prognostic biomarker and potential therapeutic target in gastrointestinal tumors显示文摘The most common digestive system(DS)cancers,including tumors of the gastrointestinal tract(GIT)such as colorectal cancer(CRC),gastric cancer(GC)and esophageal cancer(EC)as well as tumors of DS accessory organs such as pancreatic and liver cancer,are responsible for more than one-third of all cancerrelated deaths worldwide,despite the progress that has been achieved in anticancer therapy.Due to these limitations in treatment strategies,oncological research has taken outstanding steps towards a better understanding of cancer cell biological complexity and heterogeneity.These studies led to new molecular target-driven therapeutic approaches.Different in vivo and in vitro studies have revealed significant expression of B7 homologue 3(B7-H3)among the most common cancers of the GIT,including CRC,GC,and EC,whereas B7-H3 expression in normal healthy tissue of these organs was shown to be absent or minimal.This molecule is able to influence the biological behavior of GIT tumors through the various immunological and nonimmunological molecular mechanisms,and some of them are shown to be the result of B7-H3-related induction of signal transduction pathways,such as Janus kinase 2/signal transducer and activator of transcription 3,phosphatidylinositol 3-kinase/protein kinase B,extracellular signal-regulated kinase,and nuclear factor-κB.B7-H3 exerts an important role in progression,metastasis and resistance to anticancer therapy in these tumors.In addition,the results of many studies suggest that B7-H3 stimulates immune evasion in GIT tumors by suppressing antitumor immune response.Accordingly,it was observed that experimental depletion or inhibition of B7-H3 in gastrointestinal cancers improved antitumor immune response,impaired tumor progression,invasion,angiogenesis,and metastasis and decreased resistance to anticancer therapy.Finally,the high expression of B7-H3 in most common cancers of the GIT was shown to be associated with poor prognosis.In this review,we summarize the established data from different GIT cancer-related studies and suggest that the B7-H3 molecule could be a promising prognostic biomarker and therapeutic target for anticancer immunotherapy in these tumors. | Petar Rasic Maja Jovanovic-Tucovic Marija Jeremic Slavisa M Djuricic Zorica V Vasiljevic Maja Milickovic Djordje Savic | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 2 |
| 2 | Decrease of aflatoxin B1 in yogurt and acidified milk显示文摘 | RASIC J L SKRINJAR M MARKOV S | 1991 | Mycopathologia1991，113，： | 1 |
| 3 | Left ventricular hypertrophy and risk factors for its development in uraemic patients 显示文摘 | Rasic S KulenovicI Haracic A etal | 2004 | Bosn J Basic Med Sci2004，4，1： | 1 |
| 4 | Relation between certain parameters of renal function and prognosis in multiple myeloma显示文摘 | Cengic M Robovic Z Rasic S | 2001 | Med Arh2001，55，4： | 1 |
| 5 | Assimilation of cholesterol by some culture of lactic acid bacteria and bifidobacteriar显示文摘 | Rasic J L Vujicic L F Skringer M | 1992 | Biotechnology letters1992，14，： | 1 |
| 6 | Assimilation of cholesterol by some culture of lactic acid bacteria and bifidobacteria 显示文摘 | Rasic J L Vujicic I F Skrinjar M | 1992 | Biotechnology letters1992，14，1： | 1 |
| 7 | Puninotransfersses after experimental pneumoperitoneum in dogs显示文摘 | Nesek V Rasic Z Kos J | 2004 | Acta Anaesthesiol Seand2004，48，： | 1 |
| 8 | Aminotransferas- es after ex - perimental pneumoperitoneum in dogs 显示文摘 | Nesek - Adam V Rasic Z Kos J | 2004 | Acta Anaesthesiol Scand2004，48，7： | 1 |
| 9 | Assimilation of cholesterol by some cultures of lactic acid bacteria and Bifidobacteria显示文摘 | RASIC J | 1992 | Biotechnol Lett1992，14，1： | 1 |
| 10 | Puninotransfersses after experimental pneumoperitoneum indogs 显示文摘 | Nesek V Rasic Z Kos J | 2004 | Acta Anaesthesiol Seand2004，48，7： | 1 |
| 11 | Inflam- matory cytokines and malnutrition as related to risk for cardiovascular dis- ease in hemodialysis patients 显示文摘 | Perunicic - Pekovic G Pljesa S Rasic - Milutinovic Z | 2008 | Can J Physiol Pharmacol2008，86，4： | 1 |
| 12 | Assimilation of cholesterol by some culture of lactic acid bacteria and Bi fidobacteria显示文摘 | Vujicic L F Skringer M | 1992 | Biotechnol Lett1992，14，： | 1 |
| 13 | Inflammalory cytokines and malnutrition as related to risk for cardiovascular disease in hemodialysis Palients 显示文摘 | Perunicic - Pekovic G Pljesa S Rasic - Milutinovie Z | 2008 | Can J Physiol Pharmacol2008，86，4： | 1 |
| 14 | Lower serum paraoxonase- 1 activity is related to linoleic and docosahexanoic Fatty acids in type 2 diabetic patients显示文摘 | Rasic - Milutinovic Z Popovic T Perunicic - Pekovic G | 2012 | Arch Med Res2012，43，1： | 1 |
| 15 | Puninotransfersses after experimental pneumoperitoneum in dogs 显示文摘 | Nesek V Rasic Z Kos J | 2004 | Acta Anaesthesiol Seand2004，48，7： | 1 |
| 16 | Puninotransfersses after experimental pneumoperitoneum in dogs 显示文摘 | Nesek V Rasic Z Kos J | 2004 | Acta Anaesthesiol Seand2004，48，： | 1 |
| 17 | Protective associations of impor- tance of religion and frequency of service attendance with depres- sion risk, suicidal behaviors and substance use in adolescents in No- va Scotia, Canada 显示文摘 | Rasic D Kisely S Donald B | 2011 | J Affect Disord2011，132，3： | 1 |
| 18 | Assimilation of cholesterol by some cultures of Lactic Acid Bacteria and Bifidobacteria 显示文摘 | Rasic J L Vujicic I F Skrinjar M | 1992 | Biotechnology Letter1992，14，1： | 1 |
| 19 | Meta bolic syndrome in HD patients: association with body composition, nutritional status, inflammation and serum iron显示文摘 | Rasic Milutinovie Z Perunicic G Pljesa S | 2007 | Intern Med2007，46，： | 1 |
| 20 | Puninotransfersses after experimental pneumoperitoneum indogs显示文摘 | Nesek V Rasic Z Kos J | 2004 | Acta Anaesthesiol Seand2004，48，7： | 1 |
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