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| 1 | Safety and efficacy of soluble guanylate cyclase stimulators in patients with heart failure: A systematic review and meta-analysis显示文摘BACKGROUND The utility of novel oral soluble guanylate cyclase(sGC)stimulators(vericiguat and riociguat),in patients with reduced or preserved ejection fraction heart failure(HFrEF/HFpEF)is currently unclear.AIM To determine the efficacy and safety of sGC stimulators in HF patients.METHODS Multiple databases were searched to identify relevant randomized controlled trials(RCTs).Data on the safety and efficacy of sGC stimulators were compared using relative risk ratio(RR)on a random effect model.RESULTS Six RCTs,comprising 5604 patients(2801 in sGC stimulator group and 2803 placebo group)were included.The primary endpoint(a composite of cardiovascular mortality and first HF-related hospitalization)was significantly reduced in patients receiving sGC stimulators compared to placebo[RR 0.92,95%confidence interval(CI):0.85-0.99,P=0.02].The incidence of total HF-related hospitalizations were also lower in sGC group(RR 0.91,95%CI:0.86-0.96,P=0.0009),however,sGC stimulators had no impact on all-cause mortality(RR 0.96,95%CI:0.86-1.07,P=0.45)or cardiovascular mortality(RR 0.94,95%CI:0.83-1.06,P=0.29).The overall safety endpoint(a composite of hypotension and syncope)was also similar between the two groups(RR 1.50,95%CI:0.93-2.42,P=0.10).By contrast,a stratified subgroup analysis adjusted by type of sGC stimulator and HF(vericiguat vs riociguat and HFrEF vs HFpEF)showed near identical rates for all safety and efficacy endpoints between the two groups at a mean follow-up of 19 wk.For the primary composite endpoint,the number needed to treat was 35,the number needed to harm was 44.CONCLUSION The use of vericiguat and riociguat in conjunction with standard HF therapy,shows no benefit in terms of decreasing HF-related hospitalizations or mortality. | Waqas Ullah Maryam Mukhtar Aws Al-Mukhtar Rehan Saeed Margot Boigon Donald Haas Eduardo Rame | 2020 | World Journal of Cardiology2020，12，10： | 3 |
| 2 | Congenital coronary artery anomalies silent until geriatric age: non-invasive assessment, angiography tips, and treatment显示文摘冠的动脉异例(CAA ) 可以为另外的心脏病或不太经常在正常诊断过程期间作为偶然的调查结果更经常被发现根据心肌的局部缺血的表明。心血管的专业人员可以涉及他们的 angiographic 诊断,功能的评价和最终的 endovascular 治疗。一个完全的 angiographic 定义是强制的以便理解功能的效果并且在 CAA 计划任何干预:计算断层摄影术和磁性的回声成像是有用非侵略的工具检测有连续心脏的结构的异例和它的关系的三维的形态学,而冠的动脉 X 线摄影法为一幅权威的解剖图画仍然是标准答案。可能的功能的意义的一个实际想法为决定怎么管理 CAA 是强制的:非侵略的压力测试和特别地侵略药理学强调有超声监视或没有 intravascular 的测试能正确地估计大多数 CAA 的功能的意义。最后,特别 endovascular 技术和材料的知识具有为获得技术、临床的成功的首要的重要性。CAA 代表一个复杂问题,它很少在不同层次包含心血管的专业人员。关于 CAA 的主要问题的及时实际知识在如此的实体的管理是重要的。 | Gianluca Rigatelli Fabio Dell'Avvocata Nguyen Van Tan Rames Daggubati AravindaNanijundappa | 2015 | Journal of Geriatric Cardiology2015，12，1： | 2 |
| 3 | Macroscopic lymph node involve-ment and neck dissection predict lymph node recurrence in papil-lary thyroid carcinoma显示文摘 | Bardet S Malville E Rame JP | 2008 | Eur J Endocrinol2008，158，： | 1 |
| 4 | Chronic heart failure:a reversible metabolic syndrome? 显示文摘 | Rame JE | 2012 | Circulation2012，125，23： | 1 |
| 5 | A lymphatic mechanism of rotavirus extraintestinal spread in the neonatal mouse 显示文摘 | Mossel E C Raming R F | 2003 | J Virol2003，77，12： | 1 |
| 6 | Coronary thrombin increase PTCA risk:angioscopy as a clinical tool显示文摘 | Ramee SR Collins TJ | 1996 | Circulation1996，93，： | 1 |
| 7 | Developing seedless grapes by embryo rescue显示文摘 | Lamikanm O Raming D W Schell L | 1995 | Proc-Vitie-Sei-Symp1995，18，： | 1 |
| 8 | Carotid artery stenting with emboli protection surveillance study:thirty-day results of the CASES-PMS study显示文摘 | Katzen BT Criado FJ Ramee SR | 2007 | Catheter Cardiovasc Interv2007，70，7： | 1 |
| 9 | Percutaneous profundaplasty in the treatment of lower extremity ischemia: results of long-term surveillance 显示文摘 | Sliva JA White CJ Ramee SR | 2001 | J Endo Vasc Ther2001，8，： | 1 |
| 10 | Charaterization of avian reovirus induced cell fusion:the role of viral structural proteins显示文摘 | Ni Y Raming R F | 1993 | Virology1993，194，： | 1 |
| 11 | Rheolytic thrombectomy for the treatment of aortocoronary venous bypass graft thrombosis: results of the VEGAS Ⅱ trial 显示文摘 | Rames SR Ho KKL | 1999 | Circulation1999，100，1： | 1 |
| 12 | Identification of proteins encoded by avian reoviruses an devidence for post-translational modification 显示文摘 | Ni Y Raming R F Kemp M C | 1993 | Virology1993，193，： | 1 |
| 13 | Primary stenting in acute myocardial infarction:influence of diabetes mellitus in angiographic results and clinical outcome显示文摘 | SILVA J A RAMEE S R WHITE C J | 1999 | Am Heart J1999，138，： | 1 |
| 14 | Clinical rele- vance of single-photon emission computed tomo- graphy/computed tomography of the neck and tho- rax in postablation (131) I scintigraphy for thyroid eancer显示文摘 | Aide N Heutte N Rame JP | 2009 | J Clin Endocrinol Metab2009，94，6： | 1 |
| 15 | Percutaneous profundaplasty in the treatment of lower extremity ischemia:Results of long-term surveillance显示文摘 | Sliva JA White CJ Ramee SR | 2001 | J Endovasc Ther2001，8，1： | 1 |
| 16 | Coronary thrombl increase PICA risk: angioscopy as a clinical tool显示文摘 | White C Ramee SR Collins TJ | 1996 | Circulation1996，93，： | 1 |
| 17 | Left ventricular assist device management and complications显示文摘 | Birati E Y Rame J E | 2014 | Critical Care Clinics2014，30，3： | 1 |
| 18 | Clinical findings for a group of infants and young children with auditory neuropathy显示文摘 | RAME G BEAR D E CONE-WESSON B | 1999 | Ear Hear1999，20，： | 1 |
| 19 | Heart failure and cardiac hypertrophy 显示文摘 | Rame JE Dries DL | 2007 | Curr Treat Options Cardiovnsc Med2007，9，4： | 1 |
| 20 | Diabetes ketoacidosis associated with clozapine treatment (letter)显示文摘 | Koval MS Rames LJ Christie S | 1994 | Am J Psychiatry1994，151，： | 1 |
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