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469篇 您的检索式:作者名="Raghupathi"
    题名 作者 年代 出处 被引量
1Apoptosis after traumatic brain injury显示文摘Raghupathi R Graham DI McIntosh TK 2000J Neurotrauma2000,17,10:2
2GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation显示文摘Bone metastases occur in patients with advanced-stage prostate cancer(PCa). The cell-cell interaction between PCa and the bone microenvironment forms a vicious cycle that modulates the bone microenvironment, increases bone deformities, and drives tumor growth in the bone. However, the molecular mechanisms of PCa-mediated modulation of the bone microenvironment are complex and remain poorly defined. Here, we evaluated growth differentiation factor-15(GDF15) function using in vivo preclinical PCa-bone metastasis mouse models and an in vitro bone cell coculture system. Our results suggest that PCa-secreted GDF15 promotes bone metastases and induces bone microarchitectural alterations in a preclinical xenograft model. Mechanistic studies revealed that GDF15 increases osteoblast function and facilitates the growth of PCa in bone by activating osteoclastogenesis through osteoblastic production of CCL2 and RANKL and recruitment of osteomacs. Altogether, our findings demonstrate the critical role of GDF15 in the modulation of the bone microenvironment and subsequent development of PCa bone metastasis.Jawed Akhtar Siddiqui Parthasarathy Seshacharyulu Sakthivel Muniyan Ramesh Pothuraju Parvez Khan Raghupathy Vengoji Sanjib Chaudhary Shailendra Kumar Maurya Subodh Mukund Lele Maneesh Jain Kaustubh Datta Mohd Wasim Nasser Surinder Kumar Batra 2022Bone Research2022,10,1:2
3Cell Death mechanisms following traumatic brain injury 显示文摘Raghupathi R 2004Brain Pathol2004,14,2:1
4Pro-inflammatorymaternal cytokine profile in preterm delivery 显示文摘Makhseed M Raghupathy R El-Shazly S 2003Am J ReprodImmunol2003,49,5:1
5Temporal alterations in cellular Bax:Bcl-2 ratio following traumatic brain injury in the rat显示文摘Raghupathi R Strauss KI Zhang C 2003J Neurotrauma2003,20,5:1
6Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion显示文摘RAGHUPATHY R MAKHSEED M AZIZIEH F 2000Hum Reprod2000,15,3:1
7CEDAR: a core-extraction distributed Ad hoc routing algorithm 显示文摘RAGHUPATHY S PRASUN S VADUVUR B 1999IEEE Journal on Selected Areas in Communication1999,17,8:1
8Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period显示文摘Conti AC Raghupathi R Trojanowski JQ 1998J Neuroscience1998,18,15:1
9Acute activation of mitogen-activated protein kinases following traumatic brain injury in the rat: implications for posttraumatic cell death显示文摘Raghupathi R Muir J K Fulp C T 2003Exp Neurol2003,183,2:1
10Tuning of the Crystallite and Particle Sizes of ZnO Nanocrystalline Materials in Solvothermal Synthesis and Their Photocatalytic Activity for Dye Degradation显示文摘JOHN Becker KRISHNA Reddy Raghupathi 2011The Journal of Physical Chemistry2011,,13:1
11Maternal cy-tokine production patterns in women with preeclampsia显示文摘AZIZIEH F RAGHUPATHY R MAKHSEED M 2005Am JReprod Immunol2005,54,:1
12Maternal cytokine production patterns in women with pre-eclampsia 显示文摘Azizieh F Raghupathy R Makhseed M 2005Am J Reprod Immunol2005,54,1:1
13Maternal Th1 and Th2 type reactivity to placentalantigens in normal human pregnancy and unexplained recurrent spontaneous abortion显示文摘Raghupathy R Makhseed M Azizieh 1999CellImmunol1999,196,1:1
14Mitogen - induced cytokine responses of maternal peripheral blood lymphcytes indicate a differential Th- type bias in normal pregnancy and pregnancy failure 显示文摘Makhseed M Raghupathy R Azizleh F 1999Am J Reprod Immunol1999,42,:1
15Transient loss of microtubule-associated protein 2 immunoreactivity after moderate brain injury in mice 显示文摘HUH J W RAGHUPATHI R LAURER H L 2003J Neurotrauma2003,20,10:1
16Redirection of cytokine production by lymphocytes from women with pre- term delivery by dydrogesterone 显示文摘Raghupathy R AI Mutawa E Makhseed M 2007Am J Reprod Immunol2007,58,:1
17Disease activ- ity and cytokine production in mitogen-stimulated peripheral blood mononuclear ceils from patients with rheumatoid arthritis显示文摘UPPAL SS RAGHUPATHY R HAYAT SJ 2010Med Princ Pract2010,19,1:1
18Thl - type immunity is incompatible with successful pregnancy显示文摘Raghupathy R 1997Immunol Today1997,18,10:1
19Circulating cytokines and CD30 in normal human pregnancy and re-crrent spontaneous abortions显示文摘Makhseed M Raghupathy P Azizieh F 2000Hum Reprod2000,15,:1
20Apoptosis after traumatic brain injury显示文摘Raghupathi R Grahan DI Mcintosh TK 2000Neurotrauma2000,17,10:1
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