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| 1 | European vs 2015-World Health Organization clinical molecular and pathological classification of myeloproliferative neoplasms显示文摘The BCR/ABL fusion gene or the Ph^1-chromosome in the t(9;22)(q34;q11)exerts a high tyrokinase acticity,which is the cause of chronic myeloid leukemia(CML).The1990 Hannover Bone Marrow Classification separated CML from the myeloproliferative disorders essential thrombocythemia(ET),polycythemia vera(PV)and chronic megakaryocytic granulocytic myeloproliferation(CMGM).The 2006-2008 European Clinical Molecular and Pathological(ECMP)criteria discovered 3variants of thrombocythemia:ET with features of PV(prodromal PV),'true'ET and ET associated with CMGM.The 2008 World Health Organization(WHO)-ECMP and 2014 WHO-CMP classifications defined three phenotypes of JAK2^(V617F)mutated ET:normocellular ET(WHO-ET),hypercelluar ET due to increased erythropoiesis(prodromal PV)and ET with hypercellular megakaryocytic-granulocytic myeloproliferation.The JAK2^(V617F)mutation load in heterozygous WHO-ET is low and associated with normal life expectance.The hetero/homozygous JAK2^(V617F)mutation load in PV and myelofibrosis is related to myeloproliferative neoplasm(MPN)disease burden in terms of symptomaticsplenomegaly,constitutional symptoms,bone marrow hypercellularity and myelofibrosis.JAK2 exon 12mutated MPN presents as idiopathic eryhrocythemia and early stage PV.According to 2014 WHO-CMP criteria JAK2 wild type MPL^(515)mutated ET is the second distinct thrombocythemia featured by clustered giant megakaryocytes with hyperlobulated stag-horn-like nuclei,in a normocellular bone marrow consistent with the diagnosis of'true'ET.JAK2/MPL wild type,calreticulin mutated hypercellular ET appears to be the third distinct thrombocythemia characterized by clustered larged immature dysmorphic megakaryocytes and bulky(bulbous)hyperchromatic nuclei consistent with CMGM or primary megakaryocytic granulocytic myeloproliferation. | Jan Jacques Michiels Fransje Valster Jenne Wielenga Katrien Schelfout Hendrik De Raeve | 2015 | World Journal of Hematology2015，4，3： | 3 |
| 2 | Role of CCR1 and CCR5 in homing and growth of multiple myeloma and in the development of osteolytic lesions: a study in the 5TMM model显示文摘 | Menu E De Leenheer E De Raeve H | 2006 | Clin Exp Metastasis2006，23，545： | 1 |
| 3 | High performance drives coating and laminating technologies in technical textiles显示文摘 | de RAEVE A | 2001 | Hogescholl Gent2001，，6： | 1 |
| 4 | Angiogenic swith during 5T2MM murine myeloma tumori-genesis role of CD45 heterogeneity显示文摘 | ASOSINGH K DE RAEVE H MENU E | 2004 | Blood2004，103，8： | 1 |
| 5 | WHO bone marrow features and European clinical,molecular,and pathological(ECMP) criteria for the diagnosis of myeloproliferative disorders显示文摘 | Michiels JJ De Raeve H Hebcda K | 2007 | Leuk Res2007，31，8： | 1 |
| 6 | Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo显示文摘 | Guo FH De Raeve HR Rice TW | 1995 | PNAS1995，92，17： | 1 |
| 7 | A randomized, placebo-controlled study of vernakalant (oral) for the prevention of atrial fibrillation recurrence after cardioversion 显示文摘 | TORP-PEDERSEN C RAEV D H DICKINSON G | 2011 | Circ Arrhythm Electrophysiol2011，4，5： | 1 |
| 8 | The involvement of os-teopontin and its receptors in multiple myeloma cell survival,mi-gration and invasion in the murine 5T33MM model显示文摘 | Caers J Günthert U De Raeve H | 2006 | Br JHaematol2006，132，4： | 1 |
| 9 | Primary ovarian small cell carcinoma of the pulmonary type:a cases report and review of the literature显示文摘 | Mebis J De Raeve H Baekelandt M | 2004 | Eur J Gynaecol Oncol2004，25，2： | 1 |
| 10 | Curettage of giant congenital melanocytie nevi in neonates: a decade later 显示文摘 | De Raeve LE Roseeuw DI | 2002 | Arch Dermatol2002，138，7： | 1 |
| 11 | Cystosarcoma phyllodes of the prostate with rhabdomyoblastic differentiation显示文摘 | De Raeve H Jeuris W Wyndaele JJ | 2001 | Pathol Res Pract2001，197，10： | 1 |
| 12 | A randomized,placebo-controlled study of vernakalant (oral) for the prevention of atrial fibrillation recurrence after cardioversion显示文摘 | TORP-PEDERSEN C RAEV DH DICKINSON G | 2011 | Circ Arrhythm Electrophysiol2011，4，5： | 1 |
| 13 | Decreased Cu, Zn-SOD activity in asthmatit airway epithelium: correction by inhaled corticosterond in vivo显示文摘 | De Raeve H R Thunnissen F B Kaneko F T | 1997 | Am J Physiol1997，272，11： | 1 |
| 14 | Continuous ni tric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo显示文摘 | GUO F H DE RAEVE H R RICE T W | 1995 | Proc Natl Acad Sci USA1995，92，17： | 1 |
| 15 | Angiogenic switch during5T2MM murine myeloma tumorigenesis: role of CD45heterogeneity显示文摘 | Asosingh k De Raeve H Meun E | 2004 | Blood2004，103，8： | 1 |
| 16 | Angiogenic switch during 5T2MM murine myeloma tumorigenesis:role of CD45 heterogeneity 显示文摘 | Asosingh K De Raeve H Menu E | 2004 | Blood2004，103，8： | 1 |
| 17 | Surface oflocalized pleural plaques quantitated by computed tomographyscanning:no relation with cumulative asbestos exposure and noeffect on lung function显示文摘 | Van Cleemput J De Raeve H Verschakelen JA | 2001 | Am J Respiratory Critical Care Medi-cine2001，163，3： | 1 |
| 18 | Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression 显示文摘 | Asosingh K De Raeve H de Ridder M | 2005 | Haematologica2005，90，6： | 1 |
| 19 | Sorafenib has potent antitumor activity against multiple myeloma in vi-tro,ex vivo,and in vivo in the 5T33MM mouse model显示文摘 | Kharaziha P De Raeve H Fristedt C | | 0，，20： | 1 |
| 20 | Decreased Cu, Zn- SOD activity in asthmatic airway epithelium: correlation by inhaled corticosteroid in vivo显示文摘 | DE RAEVE HR THUNNISSEN FB KANEKC FT | 1997 | Am J Physiol1997，272，： | 1 |
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