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| 1 | Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease显示文摘The gastrointestinal tract harbors a large number and diverse array of commensal bacteria and is an important entry site for pathogens.For these reasons,the intestinal immune system is uniquely dedicated to protect against infections,while avoiding the development of destructive inflammatory responses to the microbiota.Several models have been proposed to explain how the immune system discriminates between,and appropriately responds to,commensal and pathogenic microorganisms.Dendritic cells(DCs)and regulatory T cells(Treg)are instrumental in maintaining immune homeostasis and tolerance in the gut.DCs are virtually omnipresent and are remarkably plastic,having the ability to adapt to the influences of the microenvironment.Different DC populations with partially overlapping phenotypic and functional properties have been described in different anatomical locations.DCs in the draining mesenteric lymph nodes,in the intestinal lamina propria and in Peyer's patches partake both in the control of intestinal inflammation and in the maintenance of gut tolerance.In this respect,gutresident DCs and macrophages exert tolerogenic functions as they regularly encounter and sense commensal bacteria.In contrast,migrating DC subsets that are recruited to the gut as a result of pathogenic insults initiate immune responses.Importantly,tolerogenic DCs act by promoting the differentiation and expansion of Treg cells that efficiently modulate gut inflammation,as shown both in preclinical models of colitis and in patients with inflammatory bowel disease(IBD).This article reviews the phenotypic and functional features of gut DC subsets and discusses the current evidence underpinning the DC contribution to the pathogenesis of the major clinical subtypes of human IBD.It also addresses the potential clinical benefit derived from DC targeting either in vivo or in vitro. | Sergio Rutella Franco Locatelli | 2011 | World Journal of Gastroenterology2011，17，33： | 13 |
| 2 | 心肌梗死后骨髓干细胞动员与左室功能 | Leone A. M. Rutella S. Bonanno G. 刘少伟 | 2005 | 世界核心医学期刊文摘(心脏病学分册)2005，0，12： | 9 |
| 3 | Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function显示文摘 | LEONE A M RUTELLA S BONANNO G | 2005 | Eur Heart J2005，26，： | 1 |
| 4 | Role for granulocyte colony stimulating factor in the generation of human T regulatory type 1 cells 显示文摘 | Rutella S Pierelli L Bonanno G | 2002 | Blood2002，100，： | 1 |
| 5 | Tolerogenic dendritic cells:cytokine modulation comes of age显示文摘 | Rutella S Danese S Leone G | 2006 | Blood2006，108，： | 1 |
| 6 | The triggering receptor ex- pressed on myeloid cells (TREM) in inflammatoly bowel disease pathogenesis显示文摘 | Genua M Rutella S Correale C | 2014 | J Transl Med2014，12，1： | 1 |
| 7 | Survival and cell cycle control in early hematopoiesis: role of bcl-2, and the cyclin dependent kinase inhibitors P27 and P21显示文摘 | Marone M Bonanno G Rutella S | 2002 | Leuk Lymphoma2002，43，1： | 1 |
| 8 | Adoptive immunotherapy with cytokine-induced killer cells generated with a new good manufacturing practice-grade protocol 显示文摘 | Rutella S Iudicone P Bonanno G | 2012 | Cytotherapy2012，14，7： | 1 |
| 9 | The triggering receptor expressed on myeloid cells(TREM)in inflammatory bowel disease pathogene-sis显示文摘 | Genua M Rutella S Correale C | 2014 | Transl Med2014，28，12： | 1 |
| 10 | The Janus face of CD4+CD25+ regulatory T cells in cancer and autoimmunity 显示文摘 | Danese S Rutella S | 2007 | Curt Meal Chert2007，14，6： | 1 |
| 11 | Cells with characteristics of cancer stem/progenitor cells express the CD133 antigen in human endometrial tumors显示文摘 | Rutella S Bonanno G Procoli A | | 0，，13： | 1 |
| 12 | Regulatory T cells and tolerogenic dendritic cells:from basic biology to clinical applications显示文摘 | Rutella S Lemoli RM | 2004 | Immunol Lett2004，94，12： | 1 |
| 13 | Endogenous G-CSF and CD34 + cell mobilization after acute myocardial infarction 显示文摘 | Leone AM Rutella S Bonanno G | 2006 | Int J Cardiol2006，111，2： | 1 |
| 14 | Adoptive immunotherapy with cytokine-induced killer cells generated with a new good manufacturing practice-grade protocol显示文摘 | Rutella S Iudicone P Bonanno G | 2012 | Cytotherapy2012，14，7： | 1 |
| 15 | Tolerogenic dendritic ceils: cytokine modulation comes of age 显示文摘 | Rutella S Danese S Leone G | 2006 | Blood2006，108，5： | 1 |
| 16 | Hepatoeyte growth factor favors monocyte differentiation into regulatory interleukin (IL) -10 + + IL-12lw/es accessory cells with dendritic-cell features 显示文摘 | Rutella S Bonanno G Proeoli A | 2006 | Blood2006，108，1： | 1 |
| 17 | Effect of intensive vs standard statin therapy on endothelial progenitor cells and left ventricular function in patients with acute myocardial infarction:Statins for regeneration after acute myocardial in- farction and PCI(STRAP)trial 显示文摘 | Leone AM Rutella S Giannieo MB | 2008 | Int J Cardiol2008，130，3： | 1 |
| 18 | Immune reconstitution after autologous peripheral blood progenitor cell transplantation: effect of interleukin-15 on T-cell survival and effector functions显示文摘 | Rutella S Pierelli L Bonanno G | 2001 | Exp Hematol2001，29，12： | 1 |
| 19 | Role for granulocyte colony-stimulating factor in the generation of human T regulatory type 1 cells显示文摘 | Rutella S Pierelli L Bonanno G | 2002 | Blood2002，100，7： | 1 |
| 20 | Cells with characteristics of cancer stem/progenitor cells express the CDl33 antigen in human endometrial tumors显示文摘 | Rutella S Bonanno G Proceli A | 2009 | Clin Cancer Res2009，15，13： | 1 |
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