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| 1 | ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy显示文摘响应滋养的应力,房间开始能导致改编或死亡的一个 autophagy 节目。位于从饥饿发信号到 autophagy 的开始下面的机制充分没被理解。在当前的学习,我们证明 PARP-1 的缺席或 inactivation 强烈推迟导致饥饿的 autophagy。我们发现了那 DNA 损坏是由 γ 测量了的导致饥饿的 autophagy 的一个早事件; -H2AX 累积和彗星试金,与在两个参数显示减小的 PARP-1 猛烈房间。在饥饿期间,导致 ROS 的 DNA 损坏激活 PARP-1,导致 ATP 弄空(在滋养的剥夺以后的一个早事件) 。PARP-1 的缺席弄钝 AMPK 激活并且阻止了 mTOR 活动的完全的损失,导致在 autophagy 的延期。PARP-1 弄空在饥饿的房间赞成 apoptosis,建议在滋养的剥夺以后的 autophagy 和 PARP-1 激活的一个支持幸存的角色。在 PARP-1 变异的老鼠的出生不满一月的婴儿使遭到了到尖锐饥饿的 vivo 结果表演,也显示缺乏的肝 autophagy,暗示为在导致饥饿的 autophagy 的 PARP-1 的一个生理的角色。因此,表明小径的 PARP 是 autophagy 承诺追随者饥饿的起始的步骤的一个关键管理者。 | Jose Manuel Rodriguez-Vargas Maria Jose Ruiz-Magana Carmen Ruiz-Ruiz Jara Majuelos-Melguizo Andreina Peralta-Lea Maria Isabel Rodriguez Jose Antonio Munoz-Gaimez Mariano Ruiz de Almodovar Eva Siles Abelardo Lopez Rivas Marja Jaattela F Javier Oliver | 2012 | Cell Research2012，22，7： | 8 |
| 2 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Sequential (step-by-step) detection, identification and quantitation of extra virgin olive oil adulterationby chemometric treatment of chromatographic profiles 显示文摘 | F Priego Capot J Ruiz Jira6nez M D Luque de Castro | 2007 | Anal Bioanal Chem2007，388，： | 1 |
| 5 | Characteristics of the heterotrophic population in hypersaline environments of different salt concentration显示文摘 | RODRIGUEZ V F RUIZ B F RAMOS C A | 1981 | Microbiol Ecol1981，7，： | 1 |
| 6 | Dispersive orderings and characterizations of aging classes显示文摘 | BELZUNCE F CANDEL J RUIZ J M | 1996 | Statistics and Probability Letters1996，28，4： | 1 |
| 7 | Consistent Knowledge Discovery in Medicine Diagnosis显示文摘 | Kovalerchuk B Vityaey E Ruiz J F | 2000 | Eng Med Biomag IEEE2000，19，4： | 1 |
| 8 | Characterization and classifica- tion of tumor lesions using computerized fractal-based tex- ture analysis and support vector machines in digital mam- mograms显示文摘 | Guo Q Shao J Q Ruiz V F | 2009 | International Journal of Computer Assisted Ra- diology and Surgery2009，4，1： | 1 |
| 9 | Germanium recovery from gasification fly ash: Evaluation of end-products obtained by precipitation methods 显示文摘 | ARROYO F FONT O FERNANDEZ-PEREIRA C QUEROL X JUAN R RUIZ C COCA P | 2009 | Journal of Hazardous Materials2009，167，123： | 1 |
| 10 | Effect of dryi/lg medium on residual moisture content and viability of freeze - dried Lactic acid bacteria显示文摘 | De Valdez G F De Giori G S De Ruiz Holgado A P | | 0，，02： | 1 |
| 11 | Increased biomagnetic activity in healthy elderly with subjective memory complaints 显示文摘 | Maestu F Baykova E Ruiz JM et aI | 2011 | Clin Neurophysiology2011，122，3： | 1 |
| 12 | A structural damage detection indicator based on principal component analysis and statistical hypothesis testing 显示文摘 | Mujica L E Ruiz M Pozo F | 2014 | Smart Materials and Structures2014，23，2： | 1 |
| 13 | Experimental study of mismatch and shading effects in the I-V characteristic of a photovoltaic module 显示文摘 | ALONSO-GARCIA M C RUIZ J M CHENLO F | 2006 | Solar Energy Materials & Solar Cells2006，90，3： | 1 |
| 14 | Comparative study of the efficiency of some additives in protecting lactic acid bacteria against freeze-drying 显示文摘 | De Valdez G F de Giori G S de Ruiz Holgado A P | 1983 | Cryobiology1983，20，： | 1 |
| 15 | Effects of air pollution on the respiratory health of asthmatic children living in Mexico City显示文摘 | Romieu I Meneses F Ruiz S | 1996 | Am J Respir Crit Care Med1996，154，21： | 1 |
| 16 | The dilation order,the dispersion order,and orderings of residual lives显示文摘 | BELZUNCE F PELLEREY F RUIZ J M | 1997 | Statistics and Probability Letters1997，33，3： | 1 |
| 17 | Countercurrent supercritical fluid extraction and fractionation of alcoholic heverages显示文摘 | Senorans F J Ruiz R A Ihanez E | 2001 | J Agric Food Chem2001，49，4： | 1 |
| 18 | Bile salts hydrolase plays a key role on cho- lesterol removal by Lactobacillus reuteri显示文摘 | TARANTO M P SESMA F DE RUIZ HOLGADO A P | 1997 | Biotech- nology Letters1997，19，9： | 1 |
| 19 | Punching of flat slabs supported on rectangular columns 显示文摘 | Sagaseta J Tassinari L Ruiz M F | 2014 | Engineering Structures2014，77，： | 1 |
| 20 | Available options in the management of non-typhi Salmonella 显示文摘 | Ruiz M Rodr f guez JC Escribano I | 2004 | Expert Opin Pharmacother2004，5，8： | 1 |
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