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| 1 | Vitamin D in esophageal cancer: Is there a role for chemoprevention?显示文摘Vitamin D has emerged as a promising anti-cancer agent due to its diverse biological effects on tumor differentiation, apoptosis and suppression of cellular proliferation. Current evidence suggests a protective role of vitamin D in colon cancer. The effect of vitamin D on esophageal cancer remains controversial. Multiple studies investigated the association between vitamin D and esophageal cancer, employing different modes of assessment of vitamin D status such as serum 25-hydroxyvitamin D levels, vitamin D dietary intake or exposure to ultraviolet B(UVB) radiation. Genetic variations of the vitamin D receptor(VDR) gene and VDR expression in esophageal specimens have also been investigated. Ecological studies evaluating exposure to UVB radiation yielded an inverse correlation with esophageal cancer. When vitamin D dietary intake was assessed, direct association with esophageal cancer was observed. However, circulating 25-hydroxyvitamin D concentrations showed inconsistent results. In this review article, we present a detailed summary of the current data on the effects of vitamin D on various histological subtypes of esophageal cancer and their precursor lesions. Well-powered prospective studies with accurate measurement of vitamin D status are needed before chemoprevention with vitamin D is recommended, as current evidence does not support a chemopreventive role of vitamin D against esophageal cancer. Future studies looking at the incidence of esophageal cancer in patients with pre-cancerous lesions(Barrett's esophagus and squamous cell dysplasia) receiving vitamin D supplementation are needed. | Carol Rouphael Afrin Kamal Madhusudhan R Sanaka Prashanthi N Thota | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 5 |
| 2 | Lymphocytic esophagitis: Still an enigma a decade later显示文摘Lymphocytic esophagitis (LE) is a clinicopathologic entity first described by Rubio et al in 2006. It is defined as peripapillary intraepithelial lymphocytosis with spongiosis and few or no granulocytes on esophageal biopsy. This definition is not widely accepted and the number of lymphocytes needed to make the diagnosis varied in different studies. Multiple studies have described potential clinical associations and risk factors for LE, such as old age, female gender and smoking history. This entity was reported in inflammatory bowel disease in the pediatric population but not in adults. Other associations include gastroesophageal reflux disease and primary esophageal motility disorders. The most common symptom is dysphagia, with a normal appearing esophagus on endoscopy, though esophageal rings, webs, nodularities, furrows and strictures have been described. Multiple treatment modalities have been used such as proton pump inhibitors and topical steroids. Esophageal dilation seems to be therapeutic when dysphagia is present along with esophageal narrowing secondary to webs, rings or strictures. The natural history of the disease remains unclear and needs to be better delineated. Overall, lymphocytic esophagitis seems to have a chronic and benign course, except for two cases of esophageal perforation in the literature, thought to be secondary to this entity. | Carol Rouphael Ilyssa O Gordon Prashanthi N Thota | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 3 | Yield,mineral composition,water relations,and water use efficiency of grafted mini-watermelon plants under deficit irrigation显示文摘 | Rouphael Y Cardarelli M Colla q Rea E | 2008 | Hort Science2008，43，3： | 1 |
| 4 | A simple model for estimating leaf area of hazelnut from linear measurements显示文摘 | Cristofori V Rouphael Y Gyves E M eta/ | 2007 | Scientia Horticulturae2007，113，2： | 1 |
| 5 | Infections associated with haemophagocytic syndrome 显示文摘 | Rouphael NG Talati NJ Vaughan C Cunningham K Moreira R Gould C | 2007 | Lancet Infect Dis2007，7，12： | 1 |
| 6 | Infections associated with haemophagocytic syndrome 显示文摘 | Rouphael NG Talati NJ Vaughan C Cunningham K Moreira R Gould C | 2007 | Lancet Infect Dis2007，，7： | 1 |
| 7 | Polymyxin B and doxycycline use in patients with multidrug-resistant Acinetobacter baumannii infections in the intensive care unit显示文摘 | Holloway K P Rouphael N G Wells J B | 2006 | Ann Pharrnacother2006，40，11： | 1 |
| 8 | Yield and water-production functions of two durum wheat cultivars grown under diffferent irrigation and nitrogen regimes显示文摘 | Karam F Kabalan R Breidi J Rouphael Y Oweis T | 2009 | Agricultural Water Management2009，94，4： | 1 |
| 9 | Strategies to increase responsiveness to hepatitis B vaccination in adults with HIV-1显示文摘 | Jennifer A Whitaker Nadine G Rouphael Srilatha Edupuganti Lilin Lai Mark J Mulligan | 2012 | The Lancet Infectious Diseases2012，，12： | 1 |
| 10 | Infections associated with haemophagocytic syndrome显示文摘 | Rouphael NG Talati NJ Vaughan C | 2007 | Lancet Infect Dis2007，7，12： | 1 |
| 11 | Neisseria meningitidis:biology,microbiology,and epidemiology显示文摘 | Rouphael NG Stephens DS | | 0，，： | 1 |
| 12 | Fruit quality of miniwatermelon as affected by grafting and irrigation regimes显示文摘 | Proietti S Rouphael Y Colla G | 2008 | Journal of the Science of Food and Agriculture2008，88，： | 1 |
| 13 | Comparison of the subirrigation and drip-irrigation systems for greenhouse zucchini squash production using saline and non-saline nutrient solutions显示文摘 | Rouphael Y Cardarelli M Rea E | 2006 | Agricultural Water Management2006，82，： | 1 |
| 14 | Grafting ofcucumber as a means to minimize copper toxicity显示文摘 | Rouphael Y Cardarelli M Rea E | 2008 | Environmental and Experimental Botany2008，63，13： | 1 |
| 15 | Infections associated with haemophagocytic syndrome显示文摘 | Rouphael NG Talati NJ Vaughan C | 2007 | Lancet Infect Dis2007，7，12： | 1 |
| 16 | Infections associated with haemophagocytic syndrome 显示文摘 | Rouphael NG Talati NJ Vaughan C | 2007 | Lancet Infect Dis2007，7，12： | 1 |
| 17 | Infections associated with haemophagocytic syndrome 显示文摘 | Rouphael NG Talati N J Vaughan C | 2007 | Lancet Infect Dis2007，7，12： | 1 |
| 18 | Modelling the transpiration of a greenhouse zucchini crop grown under a Mediterranean climate using the Penman-Monteith equation and its simplified version 显示文摘 | Youssef Rouphael Giuseppe Colla | 2004 | Australian Journal of Agricultural Research2004，55，9： | 1 |
| 19 | Yield, mineral composition, water relations, and water use efficiency of grafted mini-watermelon plants under deficit irrigation显示文摘 | Rouphael Y Cardarelli M Colla G | 2008 | HortScience2008，43，3： | 1 |
| 20 | Alleviation of salt stress by arbuscular mycorrhizal in zucchini plants grown at low and high phos- phorus concentration 显示文摘 | Colla G Rouphael Y Cardarelli M | 2008 | Biology and Fertility of Soils2008，44，3： | 1 |
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