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96篇 您的检索式：作者名="ROTHER R"

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	题名	作者	年代	出处	被引量
1	Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure.	Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz	2021	Bioactive Materials2021，6，12：	7
2	Subtype-selective antagonists of lysophosphatidic acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques显示文摘	ROTHER E BRANDL R BAKER D L	2003	Circulation2003，108，6：	2
3	Improvement in the symptoms of smooth muscle dystonia during Eculizumab therapy in paroxysmal nocturnal hemoglobinuria显示文摘	Hill A Rother R P Hillmen P	2005	Haematologica2005，90，12：	1
4	P53downregulates expression of the GI/S cell cycle phosphatase CDC25A显示文摘	Rother K Kirschner R Sanger K	2007	Oncogene2007，26，13：	1
5	Blockade of intravascular hemolysis in PNH with the Terminal Complement Inhibitor Eculizumab Unmasks Low-level hemolysis potentially occurring through C3 opsonization显示文摘	Hill A P Rother R M Risitano A	2006	Blood2006，，108：	1
6	The Effect of Slight Deformation on Droplet Coalescence in Linear Flows显示文摘	Rother M Davis R	2001	Physics of Fluids2001，13，5：	1
7	Subtype-selective an tagon is oflysophosphatidic Acid recep tors inhibit platelet activation triggered by thelipid core of atherosclerotic plaques显示文摘	ROTHER E BRANDL R BAKER D L	2003	Circulation2003，108，3：	1
8	Subtype-selective antagonists of lysophosphatidic Acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques 显示文摘	Rother E Brandl R Baker DL	2003	Circulation2003，108，6：	1
9	Buoyancy driven Coalescence of Slightly Deformable Drops 显示文摘	Rother M Zinchenko A Davis R	1997	Journal of Fluid Mechanics1997，346，：	1
10	Subtype-selective antagonists of lysophosphatidic Acid receptors inhibit platelet activation triggered by the lipid core of atherosclerotic plaques 显示文摘	Rother E Brandl R Baker DL	2003	Circulation2003，108，6：	1
11	Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria显示文摘	Rother R Rollins S Mojcik C	2007	Nat Biotechnol2007，25，11：	1
12	Characterzation of deep weathering and nanoporosity development in shale: A neutron study显示文摘	Jin L X Rother G Cole D R	2011	American Mineralogist2011，96，：	1
13	Selenoprotein synthesis in archaea显示文摘	Rother M Rescha Wilting R	2001	Biofactors2001，14，：	1
14	Effects of bamboo stands on seed rain and seed limitation in a rainforest 显示文摘	Rother D C Rodrigues R R Pizo M A	2009	Forest Ecology and Management2009，257，3：	1
15	Subtype-selective antagonists of lysophophatidic acid receptors inhabit platelet activation triggered by the lipid core of atherosclerotic plaques显示文摘	Rother E Brand R Baker DL	2003	Circulation2003，108，6：	1
16	A numerical model for fluid injection induced seismicity at Soultz-sous-Forets显示文摘	BAISCH S VOROS R ROTHER E	2010	International Journal of Rock Mechanics&Mining Sciences2010，47，3：	1
17	Complement analysis in children with idiopathic membranoproliferative glomerulonephritis: a long term follow - up显示文摘	Schwertz R Rother U Anders D	2001	Pediatr Allergy Immunol2001，12，3：	1
18	First scalar magnetic anomaly map from CHAMP satellite data indicates weak lithospheric field 显示文摘	Maus S Rother M R Holme H	2002	Geophys Res Lett2002，29，14：	1
19	Effects of exenatide alone and in combination with daclizumab on beta-cell function in long- standing type 1 diabetes显示文摘	Rother K I Spain L M Wesley R A	2009	Diabetes Care2009，32，12：	1
20	Induciable costimulator regulates Th2-mediated inflammation,but not Th2 differentiation,in a model of allergic airway disease显示文摘	Subudhi S Rother R P	2001	J Immunol2001，167，4：	1

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