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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | Beyond the Pediatric end-stage liver disease system: Solutions for infants with biliary atresia requiring liver transplant显示文摘Biliary atresia(BA), a chronic progressive cholestatic disease of infants, is the leading cause for liver transplant in children, especially in patients under two years of age. BA can be successfully treated with the Kasai portoenterostomy; however most patients still require a liver transplant, with up to one half of BA children needing a transplant by age two. In the current pediatric end-stage liver disease system, children with BA face the risk of not receiving a liver in a safe and timely manner. In this review, we discuss a number of possible solutions to help these children. We focus on two general approaches:(1) preventing/delaying need for transplantation, by optimizing the success of the Kasai operation; and(2) expediting transplantation when needed, by performing techniques other than the standard deceased-donor, whole, ABO-matched organ transplant. | Mary Elizabeth M Tessier Sanjiv Harpavat Ross W Shepherd Girish S Hiremath Mary L Brandt Amy Fisher John A Goss | 2014 | World Journal of Gastroenterology2014，20，32： | 14 |
| 3 | Colon capsule endoscopy versus standard colonoscopy in assessing disease activity of ulcerative colitis: a prospective trial显示文摘 | T. Meister H. S. Heinzow D. Domagk A. Dortgolz F. Lenze M. Ross W. Domschke A. Lügering | 2013 | Techniques in Coloproctology2013，，6： | 4 |
| 4 | Benign blue nevus of the uterine cervix 显示文摘 | Majmudar B Jeoffrey Ross R Gorelkin L | 1979 | Am J Obster Gvnecol1979，134，： | 2 |
| 5 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 6 | Liver bioengineering:Current status and future perspectives显示文摘The present review aims to illustrate the strategies that are being implemented to regenerate or bioengineer livers for clinical purposes.There are two general pathways to liver bioengineering and regeneration.The first consists of creating a supporting scaffold,either synthetically or by decellularization of human or animal organs,and seeding cells on the scaffold,where they will mature either in bioreactors or in vivo.This strategy seems to offer the quickest route to clinical translation,as demonstrated by the development of liver organoids from rodent livers which were repopulated with organ specific cells of animal and/or human origin.Liver bioengineering has potential for transplantation and for toxicity testing during preclinical drug development.The second possibility is to induce liver regeneration of dead or resected tissue by manipulating cell pathways.In fact,it is well known that the liver has peculiar regenerative potential which allows hepatocyte hyperplasia after amputation of liver volume.Infusion of autologous bone marrow cells,which aids in liver regeneration,into patients was shown to be safe and to improve their clinical condition,but the specific cells responsible for liver regeneration have not yet been determined and the underlying mechanisms remain largely unknown.A complete understanding of the cell pathways and dynamics and of the functioning of liver stem cell niche is necessary for the clinical translation of regenerative medicine strategies.As well,it will be crucial to elucidate the mechanisms through which cells interact with the extracellular matrix,and how this latter supports and drives cell fate. | Christopher Booth Tom Soker Pedro Baptista Christina L Ross Shay Soker Umar Farooq Robert J Stratta Giuseppe Orlando | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 7 | Diet and fecal lipids following cholecystectomy in men显示文摘 | BRYDON W G ROSS M C L ANDERSON J R | 1982 | Digestion1982，25，： | 1 |
| 8 | Angiopoietinl protects the adult vasculature against plasma leakage 显示文摘 | Thurston G Rudge JS Ioffe E Zhou H Ross L Croll SD | 2000 | Nat Med2000，6，4： | 1 |
| 9 | A review and update of animal toxicoses associated with fumonisin contaminated feeds and production of fumonisins by Fusarium isolates显示文摘 | ROSS P F RICE L G OSWEILER G D | 1992 | Mycopthol1992，117，： | 1 |
| 10 | Behavioural and physiological characteristicsof the Antarctic krill, Euphausia superba 显示文摘 | Quetin L Ross R M | 1991 | American Zoologist1991，31，1： | 1 |
| 11 | Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c显示文摘 | Rosse T Olivier R Monney L | 1998 | Nature1998，391，6666： | 1 |
| 12 | Review of strain rate effects for concrete in tension显示文摘 | Malvar L J Ross CA | 1998 | ACI Matreials Journal1998，95，6： | 1 |
| 13 | Average magnitude difference function pitch extractor显示文摘 | ROSS M J SHAFFER H L COHEN A | 1974 | IEEE Trans on Acoustics Speech and Signal Processing1974，22，5： | 1 |
| 14 | Numerical simulation of high strain rate concrete compress test 显示文摘 | Tedesco J W Hughes M L Ross C A | 1994 | Computers & Struc- tures1994，51，1： | 1 |
| 15 | Rapid identifieation of bacteria by direct matrix-assisted laser desorption/ionization mass spectrometric analysis of whole cells 显示文摘 | KRISHNAMURTHY T ROSS P L | 1996 | Rapid Commun Mass Spectrom1996，10，： | 1 |
| 16 | Probview: A flexible probabilistic database system 显示文摘 | Lakshmanan L V S Leone N Ross R | 1997 | ACM Transactions on Database Systems1997，22，3： | 1 |
| 17 | Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione显示文摘 | LOPACHIN R M ROSS J F REID M L | 2002 | Neurotoxicology2002，23，1： | 1 |
| 18 | An empirical study of applied game theory: Transmission constrained Cournot behavior显示文摘 | Lance B C Ross B Martin L B | 2002 | IEEE Transactions on Power Systems2002，17，1： | 1 |
| 19 | Detection of pathogenic and non-pathogenic bacteria by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry 显示文摘 | KRISHNAMURTHY T ROSS P L RAJAMANI U | 1996 | Rapid Commun Mass Spectrom1996，10，8： | 1 |
| 20 | Heart rate and blood pressure changes during gastroscopy in healthy older subjects显示文摘 | NEWTON J L | 2004 | Gerontology2004，50，3： | 1 |
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