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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma显示文摘瞄准:为病人评估经皮的乙醇注射(PEI ) 的治疗效果与先进, non-resectable HCC 与 transarterial chemoembolisation 的联合相比(不作声) 并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。方法:在学习时期期间接受了 PEI 治疗的所有病人根据物理地位和肿瘤程度被包括并且成层到下列治疗形式之一:联合不作声并且重复单个会议的 PEI,独自重复了单个会议的 PEI,重复不作声独自一个,或最好的支持的照顾。包括Okuda分类,门静脉血栓的存在,腹水的存在,肿瘤的数字,最大的肿瘤直径,和假胆硷酯酶( CHE )的临床的参数的预示的价值,以及孩子呸上演, alpha-fetoprotein (法新社),发烧,复杂并发症的发生在这些组之间被估计并且比较。幸存用 Kaplan-Meier 被决定,多,变量回归分析。结果:所有病人的 1 年、 3 年的幸存是 73% 和 47% 。在亚群分析,联合不作声, PEI (1 ) 与更长的幸存被联系(1- , 3- , 5 年的幸存:90% , 52% ,和 43%) 与 PEI 治疗相比独自一个(2 )(1- , 3- , 5 年的幸存:65% , 50% ,和 37%) 。(3 ) 在起始的层化以后的第二等的 PEI 产出可比较的结果不作声(1- , 3- , 5 年的幸存:91% , 40% ,和 30%) 当在到最好的支持的照顾(4 ) 的层化以后的 PEI 与减少的幸存被联系时(1- , 3- , 5 年的幸存:50% , 23% , 12%) 。除了选择治疗形式,为更好的幸存的预言者是肿瘤数字(n <
5 ) ,肿瘤尺寸(<
5 厘米) ,在 PEI 前的没有腹水,和在 PEI 以后的稳定的假胆硷酯酶(P <
0.05 ) 。在在 PEI 以后的 2 wk 以内的死亡是 2.8%(n = 3 ) 。有 24 (8.9%) 主修在包括部分肝梗塞,焦点的肝坏死,和肝脓肿的 PEI 以后的复杂并发症。所有复杂并发症能非通过手术被管理。结论:重复单个会议的 PEI 在有以可接受、可管理的复杂并发症率的先进 HCC 的病人是有效的。病人们成层到联合不作声, PEI 能比那些独自成层到重复 PEI 期望更长的幸存。而且,有在好临床的地位的大或多重的肿瘤的病人可以也从联合获利不作声并且为第二等的 PEI 的再考虑。 | Arne Dettmer Timm D Kirchhoff Michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal Michael Galanski Michael P Manns Joerg S Bleck | 2006 | World Journal of Gastroenterology2006，12，23： | 14 |
| 3 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 4 | Target coverage for head and neck cancers treated with IMRT: review of clinical experiences显示文摘 | Adam S Garden William H Morrison David I Rosenthal K.S.Clifford Chao K.Kian Ang | 2004 | Seminars in Radiation Oncology2004，，： | 2 |
| 5 | WONCA研究论文摘要汇编——“以病人为中心的医疗团队”工作环境及满意度调查显示文摘目的探讨初级保健医疗机构中'以病人为中心的医疗团队'的改革对工作满意度的影响。方法2009—2011年,研究者收集罗得岛州和科罗拉多州参加'以病人为中心的医疗团队'试验项目的 20个初级保健机构的原始数据,就工作环境的质量(如:诊室噪声、交流、提供安全和优质服务的困难)及满意度进行从基线至30个月时的调查,同时就压力、倦怠、30个月时离开的意向进行调查;就试验项目的影响与机构领导进行访谈;评估工作环境及满意度的纵向变化,在项目的最后一年,检查工作环境与工作满意度、压力、倦怠、离开意向之间的横断面联系。结果从基线至30个月时,罗德岛州工作满意度有所改善(P=0.03),科罗拉多州未见明显改善。两个试点项目所报告的提供安全、高质量服务的困难有所减少(P<0.001),但诊室噪声水平及质量并无明显改善。横断面分析表明,更少的提供安全和优质服务的困难、优质服务和更加开放的沟通与工作满意度提高相关。更大的诊室噪声及加强电子信息与压力及倦怠增加相关。结论 '以病人为中心的医疗团队'的改革强调质量和开放式沟通,最大限度地降低诊室噪声有助于改善工作满意度。 | Alidina S Rosenthal MB Schneider EC 本刊编辑部 | 2014 | 中国全科医学2014，17，35： | 2 |
| 6 | Increased urinary cystatin C reflects structural and functional renal tubular impairment independent of glomerular filtration rate 显示文摘 | Herget- Rosenthal S van Wijk JA Brcker- Preuss M | 2007 | Clin Biochem2007，40，： | 1 |
| 7 | Delayed posttraumatic acute subdural hematoma in elderly patients on anticoagulation显示文摘 | Itshayek E Rosenthal G Fraifeld S | 2006 | Neurosurgery2006，58，5： | 1 |
| 8 | Towards holistic 'front ends' in new product development显示文摘 | Khurana A Rosenthal S R | 1998 | Journal of Product Innovation Management1998，15，1： | 1 |
| 9 | International Nosocomial Infection Control Consortium(INICC) report,data summary for 2003-2008,issued June 2009显示文摘 | Rosenthal VD Maki DG Jamulitrat S | | 0，，02： | 1 |
| 10 | The gp41epitope,QARVLAVERY,is highly conserved and a potent inducer of IgA that neutralizes HIV-1and inhibits viral transcytosis显示文摘 | Jain S Rosenthal KL | 2011 | Mucosal Immunol2011，4，： | 1 |
| 11 | Out-of-hospital cardiac arrest and airborne fine particulate matter:a case-crossover analysis f emergency medical services data in Indianapolis,Indiana显示文摘 | ROSENTHAL F S CARNEY J P OLINGER M I | 2008 | Environ Health Perspect2008，116，5： | 1 |
| 12 | Effect of education and performance feedback on handwashing: The benefit of administrative support in Argentinean hospitals显示文摘 | Victor Daniel Rosenthal McCormick RD Guzman S | 2003 | Am J Infect Control2003，31，2： | 1 |
| 13 | Modeling magnetically insulated devices using flow impedance显示文摘 | Mendel C W Jr Rosenthal S E | 1995 | Phys Plasma1995，2，4： | 1 |
| 14 | Srong De Morgan's law and the spectrum of a commutative ring显示文摘 | Niefield S Rosenthal K I | | 0，，： | 1 |
| 15 | Socioeconomic impact on device-associated infections in pediatric intensive care units of 16limited-resource countries:International Nosocomial Infection Control Consortium findings显示文摘 | Rosenthal VD Jarvis WR Jamulitrat S | 2012 | Pediatr Crit Care Med2012，13，4： | 1 |
| 16 | Abnormalities of blood selenium and glutathione peroxidase activity in patients with acquired immunodeficiency syndrome and AIDS-related complex显示文摘 | DWORKIN B M ROSENTHAL W S WORMSER G P | 1988 | Biol Trace Elem Res1988，15，： | 1 |
| 17 | Target coverage for head and neck cancers treated with IMRT:review of clinical experiences显示文摘 | GARDEN A S MORRISON W H ROSENTHAL D I | 2004 | Semin Radiat Oncol2004，14，2： | 1 |
| 18 | Dynamic modeling of magnetically insulated transmission line systems显示文摘 | Mendel C W Jr Rosenthal S E | 1996 | Phys Plasma1996，3，11： | 1 |
| 19 | Prognostic value of tubular proteinuria and enzymuria in nonoliguric acute tubular necrosis显示文摘 | Herget Rosenthal S Poppen D Husing J | | 0，，03： | 1 |
| 20 | Optimal Scaling for Various Metropo- lis-Hastings Algorithms显示文摘 | Roberts G O Rosenthal J S | 2001 | Statistical Science2001，16，4： | 1 |
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