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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Photo- sensitizer in clinical PDT显示文摘 | ALLISON R R DOWNIE G H ROSA C | 2004 | Photodiagnosis and Photo- dynamic Therapy2004，，1： | 1 |
| 3 | Increased serum glial cell line-derived neurotrophic factor immunocontent during manic and depressive episodes in individuals with bipolar disorder显示文摘 | ROSA A R FREY B N ANDREAZZA A C | 2006 | Neurosci Lett2006，407，： | 1 |
| 4 | A new mesophase of isotactic polypropylene in copolymers of propylene with long branched comonomers 显示文摘 | De Rosa C Auriemma F Di Girolamo R | 2010 | Macromolecules2010，43，20： | 1 |
| 5 | Survival and prognostic factors in patients with resected epidermoid oesophageal carcinoma 显示文摘 | Rosa A R Gurski R R Schirmer C C | 1999 | Int Surg1999，84，3： | 1 |
| 6 | Optimization of BFO microwave hydrothermal synthesis:influence of process parameter显示文摘 | C Ponzoni R Rosa M Cannio | 2013 | J Alloys Compd2013，558，： | 1 |
| 7 | Is the application of carbendazimharmful to healthy plants?Evidence of weak phytotoxicity in tobacco显示文摘 | Pablo C G Juan M R Rosa M R | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 8 | The effect of eyestalk ablation on the energy balance of the pink shrimp, Penaeus notialis 显示文摘 | Rosas C Fernandez I Brito R | 1993 | Comparative Biochemistry and Physiology Part A : Physiology1993，104，1： | 1 |
| 9 | A first linkage map of olive( O-lea europaea L )cultivars using RAPD,AFLP,RFLP and SSR markers显示文摘 | Rosa R L Angiolillo A Guerrero C | | 0，，07： | 1 |
| 10 | Effects of low UV-B doses on the accumulation of UV-B absorbing compounds and total phenolics and carbohydrate metabolism in the peel of harvest lemons显示文摘 | Interdonato R Rosa M Nieva C B | 2011 | Environmental and Experimental Botany2011，，70： | 1 |
| 11 | Femtosecond laser versus mechanical microkera- tomes for flap creation in laser in situ keratomileusis and effect of postoperative measurement interval on estimated femtosec- ond flap thickness 显示文摘 | Rosa AM Neto-Murta J Quadrado M J Tavares C Lobo C Van Velze R | 2009 | J Cataract Refract Surg2009，35，5： | 1 |
| 12 | Proximal decom- position via alternating linearization显示文摘 | Kiwiel K C Rosa C H R Uszczynski A | 1999 | SIAM J Optim1999，9，3： | 1 |
| 13 | Multiresidue determination of 11 new fungicides in grapses and wines by liquid-liquid extraetion/clean-up and programmable temperature vaporization injection with analyte protectants/ gas chromatography/ion Irasp mass spectrometry 显示文摘 | Rosa M GonzAlez R Beatriz C G | 2009 | Journal of chromatography A2009，1216，： | 1 |
| 14 | Evaluation of the efficacy of bentonite from the south of argentina to ameliorate the toxic effects of aflatoxin in broilers 显示文摘 | Rosa C A R Miazzo R Magnoli C | 2001 | Poultry Science2001，80，： | 1 |
| 15 | Photosensitizer in clinical PDT 显示文摘 | ALLISON R R DOWNIE G H ROSA C | 2004 | Photodiagnosis and Photodynamic Therapy2004，，1： | 1 |
| 16 | B-Browder spectra and localized SVEP显示文摘 | CARPINTERO C R GARCIA O ROSAS E R | | 0，，02： | 1 |
| 17 | Fenton's oxidation process for phenolic wastewater remediation and biodegradability enhancement显示文摘 | MARTINS R C ROSSI A F ROSA M | 2010 | Journal of Hazardous Materials2010，180，123： | 1 |
| 18 | Trace elements in daily col-lected aerosol:Level characterization and source identification in a four-year study显示文摘 | MARIA R ROSA C MARIA M | 2008 | Atmospheric Research2008，89，： | 1 |
| 19 | Purification and characterization of the fimbria F18ac (2134P) isolated from enterotoxigenic Escherichia coli (ETEC) 显示文摘 | Amorim C R Matsuura M S Rosa J C | 2000 | Vet Microbiol2000，1576，1： | 1 |
| 20 | Synthesis, Molecular Modeling, and K+ Channel-blocking Activity of Dequalinium Analogues Having Semirigid Linkers显示文摘 | Rosa J C Galanakis D Ganellin C R | 1996 | J Med Chem1996，39，21： | 1 |
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