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| 1 | Chronic HCV infection and inflammation:Clinical impact on hepatic and extra-hepatic manifestations显示文摘The liver has a central role in regulating inflammation by its capacity to secrete a number of proteins that control both local and systemic inflammatory responses. Chronic inflammation or an exaggerated inflammatory response can produce detrimental effects on target organs. Chronic hepatitis C virus(HCV) infection causes liver inflammation by complex and not yet well-understood molecular pathways, including direct viral effects and indirect mechanisms involving cytokine pathways,oxidative stress and steatosis induction. An increasing body of evidence recognizes the inflammatory response in chronic hepatitis C as pathogenically linked to the development of both liver-limited injury(fibrosis, cirrhosis and hepatocellular carcinoma) and extrahepatic HCV-related diseases(lymphoproliferative disease,atherosclerosis, cardiovascular and brain disease). Defining the complex mechanisms of HCV-induced inflammation could be crucial to determine the global impact of infection, to estimate progression of the disease, and to explore novel therapeutic approaches to avert HCVrelated diseases. This review focuses on HCV-related clinical conditions as a result of chronic liver and systemic inflammatory states. | Rosa Zampino Aldo Marrone Luciano Restivo Barbara Guerrera Ausilia Sellitto Luca Rinaldi Ciro Romano Luigi E Adinolfi | 2013 | World Journal of Hepatology2013，5，10： | 13 |
| 2 | Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways显示文摘AIM To study the molecular mechanisms involved in the hepatoprotective effects of naringenin(NAR)on carbon tetrachloride(CCl4)-induced liver fibrosis.METHODS Thirty-two male Wistar rats(120-150 g)were randomly divided into four groups:(1)a control group(n=8)that received 0.7%carboxy methyl-cellulose(NAR vehicle)1 m L/daily p.o.;(2)a CCl4 group(n=8)that received 400 mg of CCl4/kg body weight i.p.3 times a week for 8 wk;(3)a CCl4+NAR(n=8)group that received 400 mg of CCl4/kg body weight i.p.3times a week for 8 wk and 100 mg of NAR/kg body weight daily for 8 wk p.o.;and(4)an NAR group(n=8)that received 100 mg of NAR/kg body weight daily for 8 wk p.o.After the experimental period,animals were sacrificed under ketamine and xylazine anesthesia.Liver damage markers such as alanine aminotransferase(ALT),alkaline phosphatase(AP),γ-glutamyl transpeptidase(γ-GTP),reduced glutathione(GSH),glycogen content,lipid peroxidation(LPO)and collagen content were measured.The enzymatic activity of glutathione peroxidase(GPx)was assessed.Liver histopathology was performed utilizing Masson’s trichrome and hematoxylin-eosin stains.Zymography assays for MMP-9 and MMP-2 were carried out.Hepatic TGF-β,α-SMA,CTGF,Col-I,MMP-13,NF-κB,IL-1,IL-10,Smad7,Smad3,p Smad3 and p JNK proteins were detected via western blot.RESULTS NAR administration prevented increases in ALT,AP,γ-GTP,and GPx enzymatic activity;depletion of GSH and glycogen;and increases in LPO and collagen produced by chronic CCl4 intoxication(P<0.05).Liver histopathology showed a decrease in collagen deposition when rats received NAR in addition to CCl4.Although zymography assays showed that CCl4 produced an increase in MMP-9 and MMP-2gelatinase activity;interestingly,NAR administration was associated with normal MMP-9 and MMP-2 activity(P<0.05).The anti-inflammatory,antinecrotic and antifibrotic effects of NAR may be attributed to its ability to prevent NF-κB activation and the subsequent production of IL-1 and IL-10(P<0.05).NAR completely prevented the increase in TGF-β,α-SMA,CTGF,Col-1,and MMP-13 proteins compared with the CCl4-treated group(P<0.05).NAR prevented Smad3phosphorylation in the linker region by JNK since this flavonoid blocked this kinase(P<0.05).CONCLUSION NAR prevents CCl4 induced liver inflammation,necrosis and fibrosis,due to its antioxidant capacity as a free radical inhibitor and by inhibiting the NF-κB,TGF-β-Smad3 and JNK-Smad3 pathways. | Erika Hernández-Aquino Natanael Zarco Sael Casas-Grajales Erika Ramos-Tovar Rosa E Flores-Beltrán Jonathan Arauz Mineko Shibayama Liliana Favari Víctor Tsutsumi José Segovia Pablo Muriel | 2017 | World Journal of Gastroenterology2017，23，24： | 10 |
| 3 | Chronic hepatitis C virus infection and atherosclerosis: Clinical impact and mechanisms显示文摘Hepatitis C virus(HCV)infection represents a major health issue worldwide due to its burden of chronic liver disease and extrahepatic manifestations including cardiovascular diseases,which are associated with excess mortality.Analysis of published studies supports the view that HCV infection should be considered a risk factor for the development of carotid atherosclerosis,heart failure and stroke.In contrast,findings from studies addressing coronary artery disease and HCV have yielded conflicting results.Therefore,meta-analytic reviews and prospective studies are warranted.The pathogenic mechanisms connecting HCV infection,chronic liver disease,and atherogenesis are not completely understood.However,it has been hypothesized that HCV may promote atherogenesis and its complications through several direct and indirect biological mechanisms involving HCV colonization and replication within arterial walls,liver steatosis and fibrosis,enhanced and imbalanced secretion of inflammatory cytokines,oxidative stress,endotoxemia,mixed cryoglobulinemia,perturbed cellular and humoral immunity,hyperhomocysteinemia,hypo-adiponectinaemia,insulin resistance,type 2 diabetes and other components of the metabolic syndrome.Understanding these complex mechanisms is of fundamental importance for the development of novel therapeutic approaches to prevent and to treat vascular complications in patients with chronic HCV infection.Currently,it seems that HCV clearance by interferon and ribavirin treatment significantly reduces non-liver-related mortality;moreover,interferon-based treatment appears to decrease the risk of ischemic stroke. | Luigi E Adinolfi Rosa Zampino Luciano Restivo Amedeo Lonardo Barbara Guerrera Aldo Marrone Fabio Nascimbeni Anna Florio Paola Loria | 2014 | World Journal of Gastroenterology2014，20，13： | 6 |
| 4 | Glycoprotein biomarkers for the detection of pancreatic ductal adenocarcinoma显示文摘Pancreatic cancer(Pa C) shows a clear tendency to increase in the next years and therefore represents an important health and social challenge. Currently, there is an important need to find biomarkers for PaC early detection because the existing ones are not useful for that purpose. Recent studies have indicated that there is a large window of time for PaC early detection, which opens the possibility to find early biomarkers that could greatly improve the dismal prognosis of this tumor. The present manuscript reviews the state of the art of the existing PaC biomarkers. It focuses on the anomalous glycosylation process and its role in PaC. Glycan structures of glycoconjugates such as glycoproteins are modified in tumors and these modifications can be detected in biological fluids of the cancer patients. Several studies have found serum glycoproteins with altered glycan chains in PaC patients, but they have not shown enough specificity for PaC. To find more specific cancer glycoproteins we propose to analyze the glycan moieties of a battery of glycoproteins that have been reported to increase in PaC tissues and that can also be found in serum. The combination of these new candidate glycoproteins with their aberrant glycosylation together with the existing biomarkers could result in a panel, which would expect to give better results as a new tool for early diagnosis of PaC and to monitor the disease. | Esther Llop Pedro E Guerrero AdriàDuran Sílvia Barrabés Anna Massaguer María JoséFerri Maite Albiol-Quer Rafael de Llorens Rosa Peracaula | 2018 | World Journal of Gastroenterology2018，24，24： | 4 |
| 5 | Metabolic alterations and chronic hepatitis C: treatment strategies显示文摘 | Luigi E Adinolfi Luciano Restivo Rosa Zampino Amedeo Lonardo Paola Loria | 2011 | Expert Opinion on Pharmacotherapy2011，，14： | 3 |
| 6 | 重组人肿瘤坏死因子与阿霉素抗人结肠癌细胞株(SW480)的序贯作用研究(英文)显示文摘目的评价 r Hu TNF和阿霉素抗人结肠癌细胞株的序贯作用。方法采用克隆生成试验 ( Hamburger- Salmon法 ) ,研究 r Hu TNF和 DOX序贯作用于 SW4 80细胞株后的抗增殖效果。结果对结肠癌细胞系 SW4 80 ,存在 DOX至 r Hu TNF序贯抗增殖作用 ;除反序贯给药情况外 ,出现显著的协同作用。结论在 DOX存在情况下 ,TNF的抗瘤作用增强 ,从而支持DOX可干扰细胞保护机制以使瘤细胞对 TNF细胞毒作用更为敏感的理论。 | 骆云鹏 LIU Rosa SALMON Sydney E | 2001 | 免疫学杂志2001，17，4： | 2 |
| 7 | Brassica by-products in diets of rainbow trout (Oncorhynchus mykiss)and their effects on performance,body composition, thyroid status and liver histology显示文摘 | Pereira O Rosa E Pires M A | 2002 | Animal Feed Science and Technology2002，101，： | 1 |
| 8 | Enhanced Cooperative Absorption and Upconversion in Yb^3+ Doped YAG Nanophosphors显示文摘 | Diaz-Torres L A Rosa E D Salas P | 2005 | Optical Matersials2005，27，： | 1 |
| 9 | Antidiabetic therapy in real practice: indicators for adherence and treatment cost显示文摘 | Colombo GL Rossi E De Rosa M | 2012 | Patient Prefer Adherence2012，6，： | 1 |
| 10 | Static and Dynamic Behavior of a Rigid Rotor on Journal Bearings显示文摘 | Della P L De Rosa E | 1991 | Meccanica1991，26，4： | 1 |
| 11 | Funding systems for higher education and their impacts on institutional strategies and academia:A comparative perspective显示文摘 | Frlich N Schmidt E K Rosa M J | 2010 | International Journal of Educational Management2010，24，1： | 1 |
| 12 | Comparative study of the spectroscopic properties of Yb3+/Er3+ codoped tellurite glasses modified with R2O(R = Li,Na and K)显示文摘 | DESIRENA H De la ROSA E ROMERO V H | | 0，，02： | 1 |
| 13 | STIRPAT, IPAT and IMPACT: analytic tools for unpacking the driving forces of environmental impacts 显示文摘 | York R Rosa E A Dietz T | 2003 | Ecological Economics2003，46，3： | 1 |
| 14 | The Future of Nuclear Power: Value Orientations and Risk Perception 显示文摘 | WHITFIELD S C ROSA E A DAN A | 2009 | Risk Analysis2009，29，3： | 1 |
| 15 | A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome显示文摘 | Claudia M Tonino E Rosa D P | 2002 | Diabetes2002，51，7： | 1 |
| 16 | Striatal and forebrain nuclei volumes:contribution to motor function and working memory deficits in alcoholism显示文摘 | Sullivan EV Deshmukh A De Rosa E | 2005 | Biol Psychiatry2005，57，7： | 1 |
| 17 | Graftversus-host disease,an eight case report and literature review 显示文摘 | de la Rosa Garcia E Bologna Molina R Vega Gonzflez Tde J | 2006 | Med Oral Patol Oral Cir Bucal2006，11，6： | 1 |
| 18 | Rethinking the Environmental Impacts of Population,Affluence and Technology显示文摘 | Dietz T Rosa E A | 1994 | Human Ecology Review1994，，01： | 1 |
| 19 | The17q12-q21amplicon:Her2 and topoisomerase-IIalpha and their importance to the biology of solid tumours显示文摘 | Mano MS Rosa DD De Azambuja E | 2007 | Cancer Treat Rev2007，33，： | 1 |
| 20 | Bridging environmental science with environmental policy:Plasticity of population,affluence and technology 显示文摘 | York R Rosa E A Dietz T | 2002 | Social Science Quarterly2002，83，1： | 1 |
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