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| 1 | Microbial markers in colorectal cancer detection and/or prognosis显示文摘Colorectal cancer(CRC) is the second leading cause of cancer worldwide. CRC is still associated with a poor prognosis among patients with advanced disease. On the contrary, due to its slow progression from detectable precancerous lesions, the prognosis for patients with early stages of CRC is encouraging. While most robust methods are invasive and costly, actual patient-friendly screening methods for CRC suffer of lack of sensitivity and specificity. Therefore, the development of sensitive, non-invasive and cost-effective methods for CRC detection and prognosis are necessary for increasing the chances of a cure. Beyond its beneficial functions for the host, increasing evidence suggests that the intestinal microbiota is a key factor associated with carcinogenesis. Many clinical studies have reported a disruption in the gut microbiota balance and an alteration in the faecal metabolome of CRC patients, suggesting the potential use of a microbialbased test as a non-invasive diagnostic and/or prognostic tool for CRC screening. This review aims to discuss the microbial signatures associated with CRC known to date, including dysbiosis and faecal metabolome alterations, andthe potential use of microbial variation markers for noninvasive early diagnosis and/or prognostic assessment of CRC and advanced adenomas. We will finally discuss the possible use of these markers as predicators for treatment response and their limitations. | Romain Villéger Amélie Lopès Julie Veziant Johan Gagnière Nicolas Barnich Elisabeth Billard Delphine Boucher Mathilde Bonnet | 2018 | World Journal of Gastroenterology2018，24，22： | 10 |
| 2 | 语前聋儿童人工耳蜗植入效果的评估显示文摘目的探索语前聋儿童人工耳蜗植入效果的评估方法.方法受试者为18名接受人工耳蜗植入的语前聋儿童,耳蜗植入时平均年龄6岁.按人工耳蜗使用时间长短分为四个阶段进行评估:第一阶段18名患儿,使用人工耳蜗1~12个月;第二阶段12名,使用人工耳蜗13~24个月;第三阶段8名,使用人工耳蜗25~36个月;第四阶段6名,使用人工耳蜗在36个月以上.描述性分析,以问卷的形式了解儿童在人工耳蜗植入后声音接受、言语表达及行为等方面的变化;言语测试,进行言语识别能力和发声能力测试.结果第一阶段患儿,能够感知和辨别来自家庭和环境中的声音;第二阶段患儿,封闭项词识别率是51%,开放项词识别开始启动;第三阶段患儿,封闭项词识别率达到72%,开放项词识别率是40%,能正确发出的单词数是42%;第四阶段患儿,封闭项词识别率和开放项词识别率分别达到84%和53%,能正确发出的单词数达62%,部分患儿已有自发的口语表达.结论人工耳蜗植入对语前聋患儿的言语发育有帮助,患儿的言语能力随着人工耳蜗使用时间的推移不断进步. | 于萍 Romain S Triglia JM Guarella MD | 2004 | 中华耳科学杂志2004，2，2： | 8 |
| 3 | Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis 显示文摘 | Taleb S Romain M Ramkhelawon B | 2009 | J Exp Med2009，206，： | 1 |
| 4 | Enterohepatie bacterial infections dysregulate the FGF15-FGFR4 endocrine axis 显示文摘 | Romain G Tremblay S Arena ET | 2013 | BMC Mierobiol2013，13，： | 1 |
| 5 | Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis 显示文摘 | Taleb S Romain M Ramkhe]awon B | 2009 | J Exp Med2009，206，10： | 1 |
| 6 | Frequency and genome load of Epstein-Barr virus in 509 breast cancers from different geographical areas 显示文摘 | Fina F Romain S Ouafik L | 2001 | Br J Cancer2001，84，6： | 1 |
| 7 | Thymidine kinase as a proliferative marker: clinical relevance in 1692 primary breast cancer patients 显示文摘 | Brot P Romain S Daver A | 2001 | J Clin Oncol2001，19，： | 1 |
| 8 | Thymidine kinase as a prolifer- ative marker: clinical relevance in 1692 primary breast cancer patients显示文摘 | Brot P Romain S Daver A | 2001 | J Clin Oneol2001，19，11： | 1 |
| 9 | Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer显示文摘 | Romain B Hachet-Haas M Rohr S | 2014 | Mol Cancer2014，13，1： | 1 |
| 10 | Thymidine Kinase as a proliferative marker:clinical relevance in 1,692 primary bresast cancer patients显示文摘 | Broet P Romain S Daver A | | 0，，11： | 1 |
| 11 | Indications for and results of arthroscopy in the arthritic knee: a European survey显示文摘 | Hermann OM Matthias R Romain S | 2013 | Int Orthop2013，37，7： | 1 |
| 12 | Silencing of Cdc42 inhibits neuroblastoma cell proliferation and transformation 显示文摘 | Lee S Craig BT Romain CV | 2014 | Cancer Letters2014，355，2： | 1 |
| 13 | Age as a prognostic factor in breast cancer:relationship to pathologic and biologic features显示文摘 | Bonnier P Romain S Charpin C | 1995 | Int J Cancer1995，62，1： | 1 |
| 14 | Molecular Characterization of New Selective Peroxisome Prolifer- ator- Activated Receptor Modulators With Angioten - sin Receptor Blocking Activity 显示文摘 | Michael S Junkus C Romain G | 2005 | Diabetes2005，，54： | 1 |
| 15 | Thymidine kinase as a proliferative marder:clinical relevance in 1 692 primary breast caner patients显示文摘 | Bro(e)t P Romain S Daver A | 2001 | J Clin Oncol2001，19，11： | 1 |
| 16 | Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin - 17 in atherosclerosis 显示文摘 | Taleb S Romain M Ramkhelawon B | 2009 | J Exp Med2009，206，10： | 1 |
| 17 | Norm-referenced and criterion- referenced reliability of the push-up and modified pull-up显示文摘 | ROMAIN B S MAHAR M T | 2001 | Meas Phys Edu Exe Sci2001，5，： | 1 |
| 18 | Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in athernsclerosis显示文摘 | Taleb S Romain M Ramkhelawon B | | 0，，10： | 1 |
| 19 | Thymidine kinase as a proliferative marker: clinical relevance in 1,692 primary breast cancer patients 显示文摘 | Broet P Romain S Daver A | 2001 | J Clin Oncol2001，19，11： | 1 |
| 20 | Loss of SOCS3 expression in T calls reveals a regulatory role for interleukin - 17 in atherosclerosis显示文摘 | TALEB S ROMAIN M RAMKHELAWON B | 2009 | J Fap Med2009，206，10： | 1 |
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