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| 1 | Intraductal papillary neoplasm of the bile ducts: A case report and literature review显示文摘Intraductal papillary neoplasm of the bile duct(IPNB) is a rare bile duct neoplasm mostly found in far eastern nations where hepatolithiasis and clonorchiasis infections are endemic. In western countries,it is very rare and the etiology is unknown. In this article,we report the first IPNB patient we encountered in our clinic and a literature review. The patient is a 38-yearold female with a history of choledocholithiasis who presented with obstructive jaundice. She was found to have a papillary mass at the junction of the right hepatic duct and common hepatic duct with six masses in the liver parenchyma. The immunophenotypic and histologic features of the tumor are consistent with IPNB,gastric subtype. The patient had a partial hepatectomy and has been receiving palliative chemotherapy. In a search of Pub Med database,we collected 354 IPNB patients reported in 22 articles. In these patients,52.8% were from Japan and 27.7% were from western countries including the United States(11.0%). The age of the patients ranged from 35 to 80 years old with an average of 64.6. Male/female ratio was 1.5. Macroscopically,57.5% of the tumors were in the left lobe and 29.5% were in the right lobe. The average size of the tumor were 4.2 cm at the time of diagnosis. Histologically,pancreato-biliary subtype accounted for 41.8%,intestinal 28.0%,gastric 13.5% and oncocytic 16%. An invasive component is most often present in the pancreato-biliary and gastric subtypes. Despite recent advanced technologies,diagnosis of IPNB is still challenging,especially in western countries due to its rarity. Defined clinicopathologic features are in demand for the accurate diagnosis and proper treatment. | Yaohong Tan Clara Milikowski Yanelba Toribio Adam Singer Claudia P Rojas Monica T Garcia-Buitrago | 2015 | World Journal of Gastroenterology2015，21，43： | 19 |
| 2 | Diabetes and cancer:Looking at the multiligand/RAGE axis显示文摘The association between diabetes and hyperglycemia and the associated increased risk of several solid and hematologic malignancies has been the subject of investigation for many years.Although the association is not fully understood,current knowledge clearly indicates that diabetes may influence malignant cell transformation by several mechanisms,including hyperinsulinemia,hyperglycemia and chronic inflammation.In this context,the receptor for advanced glycation end-products (RAGE) has emerged as a focal point in its contribution to malignant transformation and tumor growth.We high-light how RAGE,once activated,as it manifests itself in conditions such as diabetes or hyperglycemia,is able to continuously bring about an inflammatory milieu,thus supporting the contribution of chronic inflammation to the development of malignancies. | Armando Rojas Ileana González Erik Morales Ramón Pérez-Castro Jacqueline Romero Héctor Figueroa | 2011 | World Journal of Diabetes2011，2，7： | 11 |
| 3 | Can testosterone therapy be offered to men on active surveillance for prostate cancer? Preliminary results显示文摘这份报告在活跃监视上在 T 缺乏的人的一个队与 T 治疗介绍我们的经验(作为) 为 Gleason 3 + 3 并且 Gleason 3 + 4 前列腺癌症(PCa ) 。回顾的图表评论与 T 缺乏识别了 28 个人经历 T 治疗(T 组) 至少 6 个月了当时在上至于 PCa。96 个人在上的一个比较组至于有未经治疗的 T 缺乏的 PCa (别组织) 在一样的机构被识别。同样协议跟随了修改爱泼斯坦标准和有小量的 Gleason 3 + 的一个单个核心的人的允许的包括 4 PCa。吝啬的年龄是 59.5 和 61.3 年,并且意味着后续是为 T 的 38.9 和 42.4 个月并且不分别地组织。在 T 组的所有 28 个人, 3 (10.7%) 人们在格利森分数开发了增加当时在上作为。22,在 T 的人与 Gleason 3 + 组织 3 疾病, 7 (31.8%) 人们包括开发了 Gleason 3 + 的 3 个人(13.6%) 开发了活体检视前进 4 PCa。有 Gleason 3 + 的 6 个人在基线的 4 疾病, 2 (33.3%) 人们在肿瘤体积开发了增加,并且任何一个都没发展在 Gleason 3 + 以外升级 4。所有 96 个人在别组织有的 Gleason 3 + 在基线的 3 疾病并且,(44.7%) 43 开发了活体检视前进,包括有升级到 Gleason 7 的 9 个人(9.38%)(3 + 4 ) 。活体检视前进率为组和历史的控制是类似的。在人在上的活体检视前进作为在 3 年由 T 治疗显得未受影响。在 T 缺乏的人在上的 T 治疗的未来的控制安慰剂的试用作为应该被认为给对待的人经验丰富的征兆的好处。 | Ravi Kacker Mariam Hult Ignacio F San Francisco William P Conners Pablo A Rojas William C Dewolf Abraham Morgentaler | 2016 | Asian Journal of Andrology2016，18，1： | 2 |
| 4 | Acute activation or Maxi-Kchannels (hSlo) by estradiol binding to the beta subunit显示文摘 | Rojas P Amigo J | 1999 | Scince1999，285，： | 1 |
| 5 | A prospective randomized study comparing D2 total gastrectomy versus D2 total gastrectomy plus splenectomy in 187 patients with gastric carcinoma显示文摘 | Csendes A Burdiles P Rojas J Braghetto I Diaz JC Maluenda F | 2002 | Surgery2002，131，4： | 1 |
| 6 | Hybrid furoxanyl N-acy lhydrazone derivatives as hits for the development of neglected diseases drug candidates显示文摘 | HERNANDEZ P ROJAS R GILMAN R H | 2012 | European Journal of Medicinal Chemistry2012，59，： | 1 |
| 7 | Pendimethalin and oxyfluorfen degradation under two irrigation conditions over four years application 显示文摘 | Alister C A Gomez P A Rojas S | 2009 | Journal of Environment Science Health B2009，44，： | 1 |
| 8 | Acute activation of Maxi-K channels(h Slo)by estradiol binding to theβsubunit显示文摘 | Valverde MA Rojas P Amigo J | 1999 | Science1999，285，： | 1 |
| 9 | A dot-blot assay for adhesive components relative to probiotics显示文摘 | ROJAS M CONWAY P L | 2001 | Methods Enzymol2001，336，4： | 1 |
| 10 | Frequencies of virus-specific CD4 + and CD8 + T lymphocytes secreting gamma interferon after acute natural rotavirus infection in children and adults显示文摘 | Jaimes MC Rojas OL González AM Cajiao I Charpilienne A Pothier P | 2002 | J Virol2002，76，10： | 1 |
| 11 | Traumatic colonic perforation: review of 16 years experience显示文摘 | Wiener I Rojas P Wolma FJ | 1981 | Am J Surg1981，142，： | 1 |
| 12 | Cell populations and adhesion molecules expression in conjunctiva before and after bone marrow transplantation显示文摘 | Rojas B Cuhna R Zafirakis P | 2005 | Exp Eye Res2005，81，3： | 1 |
| 13 | Prnspectivcly ECG-trig- gered high-pitch spiral acquisition for cardiac CT angingraphy in routine clinical practice:initial resuhs显示文摘 | Kropil P Rojas C Ghoshhajra B | 2012 | J Thorae Imaging2012，27，3： | 1 |
| 14 | A prospective randomized study comparing D2 total gastrectomy versus D2 total gastrectomy plus splenectomy in 187 patients with gastric carcinoma显示文摘 | Csendes A Burdiles P Rojas J | 2002 | Surgery2002，131，4： | 1 |
| 15 | Anti - inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae) 显示文摘 | Aguilar JL Rojas P Marcelo A | 2002 | J Ethnopharmacol2002，81，2： | 1 |
| 16 | Seismic performance of posttensioned steel moment resisting frames with friction devices显示文摘 | Rojas P Ricles J Sause R | 2005 | Journal of Structural Engineering ASCE2005，131，4： | 1 |
| 17 | A prospective randomized study comparing D2 total gastrectomy versus D2 total gastrectomy plus splenectomy in 187 patients with gastric carcinoma显示文摘 | Csendes A Burdiles P Rojas J | 2002 | Sur- gery2002，131，4： | 1 |
| 18 | Larvicidal, antimycobacterial and antifungal compounds from the bark of the peruvian plant Swartzia polyphylla DC显示文摘 | Rojas R Bustamante B Ventosilla P | 2006 | Chem Pharm Bull2006，54，2： | 1 |
| 19 | Phenotypic comparison of periodontal ligament cells in vivo and in vitro显示文摘 | Lekic P Rojas J Birek C | 2001 | J Periodontal Res2001，36，2： | 1 |
| 20 | New disguises for an old channel: MaxiK channel beta-subunits显示文摘 | Orio P Rojas P Ferreira G | 2002 | News Physiol Sci2002，17，： | 1 |
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