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	题名	作者	年代	出处	被引量
1	Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years.	Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer	2014	World Journal of Gastroenterology2014，20，7：	5
2	Microglia as a pharmacological target in infectious and inflammatory diseases of the brain显示文摘	Rock R B Peterson P K	2006	J NeuroimmunePharmacol2006，1，：	1
3	Repcatplateletpheresis: the effects on the donor and the yield 显示文摘	Rock G Tittley P Sternbach M	1992	Vox Sang1992，63，5：	1
4	Electrochemical in- vestigation of the surface-modifying roles of guanidine carbonate in chemical mechanical planarization of tantalum 显示文摘	ROCK S E CRAIN D J ZHENG J P	2011	Materials Chemistry and Physics2011，129，3：	1
5	Long-term results of meniscus repair and meniscectomy:a 13 year functional and radiographic follow-up study显示文摘	Rock P Messner K		0，，01：	1
6	An investigation into the relationship between the cranial base angle and malocclusion显示文摘	Dhopatkar A Bhatia S Rock P	2002	The Angle orthodontist2002，72，5：	1
7	Commonage Land and Farmer Up- take of the Rural Environment Protection Scheme in Ireland 显示文摘	Van Rensburg T M Murphy E Rocks P	2009	Land Use Policy2009，26，2：	1
8	Food and drug adminstration drug approval summary: sunitinib malate for the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma显示文摘	Rock E P Goodman V Jiang J X	2007	Oncologist2007，12，1：	1
9	Approval summary sunitinib for the treatment of imatinib refractory or intolerant gastrointestinal stromal tumors and advancedrenal cell carcinoma 显示文摘	Goodman V L Rock E P Dagher R	2007	Clin Cancer Res2007，13，5：	1
10	Women at altitude:energy requirement at 4,300 m显示文摘	MAWSON J T BRAUN B ROCK P B	2000	J Appl Physiol2000，88，1：	1
11	A compariaon of different ligation methods on friction显示文摘	Hain M Dhopatkar A Rock P	2006	Am J Orhtod Dentofacial Orthop2006，130，5：	1
12	Combination of quantitative IMP3 and tumor stage: a new system to predict metastasis for patients with localized renal cell carcinomas显示文摘	Jiang Z Chu P G Woda B A Liu Q Balaji K C Rock K L	2008	Clin Cancer Res2008，14，：	1
13	Role of dietary polyamines in a phase III clinical trial of difluoromethylornithine(DFMO)and sulindac for prevention of sporadic colorectal adenomas显示文摘	Raj K P Zell J A Rock C L	2013	Br J Cancer2013，108，3：	1
14	Assessing proar- rhythmic potential of drugs when optimal studies are infeasible 显示文摘	ROCK E P FINKLE J FINGETER H J	2009	Am Heart J2009，157，5：	1
15	Cartilage oligomeric ma- trix protein promotes cell attachment via two independent mecha- nisms involving CD47 and ctV3 integrin显示文摘	Rock MJ Holden P Horton WA	2010	Mol Cell Biochem2010，338，12：	1
16	Terbium chelate for use as a label in fluorescent immunoassays 显示文摘	Bailey M P Bernard F Rocks F etal	1984	Analyst1984，109，：	1
17	The effect of different combinations of tip and torque on arch-wire/bracket friction显示文摘	Hamdan A Rock P	2008	Eur J Orthod2008，30，5：	1
18	The effect of ligation method on friction in sliding mechanics显示文摘	Hain M Dhopatkar A Rock P	2003	Am J Orthod Dentofaeial Orthop2003，123，4：	1
19	No-nitro-Larginine and puhnonary vascular pressure-flow relation in conscious doges显示文摘	Rock P	1992	Am J Physiol1992，262，：	1
20	Electrochemical in?vestigation of the surface-modifying roles of guanidine carbonate in chemical mechanical planarization of tantalum显示文摘	ROCK S E CRAIN DJ ZHENGJ P	2011	Materials Chemistry and Physics2011，129，3：	1

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