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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Puerto rican drugs users, esperiences of physical and sexual abuse: comparisons based on sexual identities 显示文摘 | FINLINSON H A ROBLES R R COLON H M | 2003 | J Sex Research2003，40，3： | 1 |
| 3 | Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels显示文摘 | Larcher F Robles AI Duran H | | 0，，23： | 1 |
| 4 | A novel circulating loop bioreactor with cells immobilized in loofa (luffa cylindrica) sponge for the bioconversion of raw cassava starch to ethanol 显示文摘 | Roble N Ogbonna J Tanaka H | 2003 | Applied Microbiology and Biotechnology2003，60，6： | 1 |
| 5 | Mechanical signaling for bone modeling and remodeling显示文摘 | Robling A G Turner C H | 2009 | Crit Rev Eukaryot Gene Expr2009，19，4： | 1 |
| 6 | Up - regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H - ras expression levels 显示文摘 | Larcher F Robles Al Duran H | 1996 | Cancer Res1996，56，23： | 1 |
| 7 | L-Lactic acid production from raw cassava starch in a circulating loop bioreactor with cells immobilized in loofa (luffa cylindrica) 显示文摘 | Roble N D Ogbonna J C Tanaka H | 2003 | Biotechnology Letters2003，25，13： | 1 |
| 8 | The RON1/FRY1/SAL1 gene is required for leaf morphogenesis and venation patterning in Arabidopsis 显示文摘 | Robles P Fleury D Candela H | 2010 | Plant Physiol2010，152，3： | 1 |
| 9 | Characterization of fly ash from Israel with reference to its possible utilization显示文摘 | Foner H A Robl T L Hower J C | 1999 | Fuel1999，78，： | 1 |
| 10 | A novel circulating loop bioreactor with cells immobilized in loofa (luffa cylindrical) sponge for the bioconversion of raw cassava starch to ethanol显示文摘 | Roble N Ogbonna J Tanaka H | 2003 | Applied Microbiology and Biotechnology2003，60，6： | 1 |
| 11 | Seismic Performance of Circular High strength Concrele Col umns显示文摘 | PAULTRE P EID R ROBLES H I | 2009 | ACI Structural Journal2009，106，39： | 1 |
| 12 | Effects of biomechanical stress on bones in animals显示文摘 | Burr D B Robling A G Turner C H | 2002 | Bone2002，30，5： | 1 |
| 13 | Correlation between the levels of circulating adhesion molecules and atherosclerosis in type-2 diabetic normotensive patients:circulating adhesion molecules and atherosclerosis显示文摘 | Rubio Guerra AF Vargas Robles H Serrano AM | 2009 | Cell Adh Migr2009，3，4： | 1 |
| 14 | Control of radiofrequeney lesion size by power regulation显示文摘 | WITTKAMPF F H HAUER R N ROBLES D E | 1989 | Circulation1989，80，： | 1 |
| 15 | A novel circulating loop bioreactor with cells immobilized in loofa ( Luffa cylindrica)sponge for the bioconversion of raw cassava starch to ethanol 显示文摘 | Roble ND Ogbonna JC Tanaka H | 2003 | Appl Microbiol Biotechnol2003，60，6： | 1 |
| 16 | Parasagittal transinsular electrodes for stereo-EEG in temporal and insular lobe epilepsies 显示文摘 | Robles SG Gelisse P E1 Fertit H | 2009 | Stereotaet Fnnet Neurosurg2009，87，6： | 1 |
| 17 | Correlation between circulating adhesion molecule levels and albuminuria in type -2 diabetic hypertensive patients 显示文摘 | Rubio - Guerra AF Vargas - Robles H Lozano Nuevo JJ | 2009 | Kidney Blood Press Res2009，32，2： | 1 |
| 18 | Chelated minerals:their role in bovine fertility显示文摘 | Manspeaker J E Robl M G Edwards G H | 1993 | Veterinary Medicine1993，82，： | 1 |
| 19 | Comparison a mong chemical and electromagnetic stirring and vibration melt treatments for A1-Si hypereutectie alloys 显示文摘 | ROBLES HERNANDEZ F C SOKOLOWSKI J H | 2006 | Journal of Alloys and Compounds2006，426，： | 1 |
| 20 | Recovery peri- ods restore mechanosensitivity to dynamically loaded bone 显示文摘 | ROBLING A G BURR D B TURNER C H | 2001 | J ExpBiol2001，204，19： | 1 |
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