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| 1 | ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy显示文摘响应滋养的应力,房间开始能导致改编或死亡的一个 autophagy 节目。位于从饥饿发信号到 autophagy 的开始下面的机制充分没被理解。在当前的学习,我们证明 PARP-1 的缺席或 inactivation 强烈推迟导致饥饿的 autophagy。我们发现了那 DNA 损坏是由 γ 测量了的导致饥饿的 autophagy 的一个早事件; -H2AX 累积和彗星试金,与在两个参数显示减小的 PARP-1 猛烈房间。在饥饿期间,导致 ROS 的 DNA 损坏激活 PARP-1,导致 ATP 弄空(在滋养的剥夺以后的一个早事件) 。PARP-1 的缺席弄钝 AMPK 激活并且阻止了 mTOR 活动的完全的损失,导致在 autophagy 的延期。PARP-1 弄空在饥饿的房间赞成 apoptosis,建议在滋养的剥夺以后的 autophagy 和 PARP-1 激活的一个支持幸存的角色。在 PARP-1 变异的老鼠的出生不满一月的婴儿使遭到了到尖锐饥饿的 vivo 结果表演,也显示缺乏的肝 autophagy,暗示为在导致饥饿的 autophagy 的 PARP-1 的一个生理的角色。因此,表明小径的 PARP 是 autophagy 承诺追随者饥饿的起始的步骤的一个关键管理者。 | Jose Manuel Rodriguez-Vargas Maria Jose Ruiz-Magana Carmen Ruiz-Ruiz Jara Majuelos-Melguizo Andreina Peralta-Lea Maria Isabel Rodriguez Jose Antonio Munoz-Gaimez Mariano Ruiz de Almodovar Eva Siles Abelardo Lopez Rivas Marja Jaattela F Javier Oliver | 2012 | Cell Research2012，22，7： | 8 |
| 2 | Decreased transcription,expression and function of low-density lipoprotein receptor in leukocytes from patients with systemic lupus erythematosus显示文摘 | Rivas L Zabaleta M Toro F | 2009 | Autoimmunity2009，42，4： | 1 |
| 3 | Computation of the RCS of Complex Bodies Modeled Using NUBBUS Surfaces显示文摘 | Domingo M M Rivas F Perez J | 1995 | IEEE Antennas and Propagation Magazine1995，37，6： | 1 |
| 4 | Girdling effects on fruit set and quantum yield efficiency of PSII in two Citrus cultivars 显示文摘 | Rivas F Gravina A Agusti M | 2007 | Tree Physiology2007，27，4： | 1 |
| 5 | Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature显示文摘 | Dentali F Riva N Crowther M | 2012 | Circulation2012，126，： | 1 |
| 6 | Menisci in arrays of cylinders: Numerical simulation by finite elements显示文摘 | Orr F M Scriven L E Rivas A P | 1975 | Journal Of Colloid And Interface Science1975，52，3： | 1 |
| 7 | The expanding role of BDNF:a therapeutic target for Alzheimer' s disease显示文摘 | Racagni G Riva MA | 2006 | Pharmacoge-nomics J2006，6，1： | 1 |
| 8 | Analysis of 78 patients studied with computed omography 显示文摘 | Cordobes F Lobcdo RD Rivas JJ | 1986 | Acta Neuro Chirurgica1986，81，1： | 1 |
| 9 | Testing for an unusual distribution of rare variants 显示文摘 | Neale B M Rivas M A Voight B F | 2011 | PLoS Genet2011，7，10： | 1 |
| 10 | The cortical signature of amyo- trophic lateral sclerosis显示文摘 | Agosta F Valsasina P Riva N | 2012 | PLoS One2012，7，42： | 1 |
| 11 | Expression of granulocyte macrophage-colony-stimulating factor receptors in human prostate cancer显示文摘 | Rivas CI Vera JC Delgado-Lopez F | 1998 | Blood1998，91，3： | 1 |
| 12 | Stabilized leachates: sequential coagulation - flocculation + chemical oxidation process显示文摘 | Rivas F J Behran F Carvalho F | 2004 | Journal of Hazardous Materials2004，116，： | 1 |
| 13 | Catalytic ozonation of oxalic acid in an aqueous TiO2 slurry reactor显示文摘 | FERNANDO J B BELTRAN F J RIVAS R | 2002 | Applied Catalysis B: Environmental2002，39，： | 1 |
| 14 | Acute epidural hematoma:an analysis of factors influencing the outcome of patients undergoing surgery in coma显示文摘 | Lobato RD Rivas JJ Cordobes F | 1988 | J Neurosurg1988，68，1： | 1 |
| 15 | 显示文摘 | Hueso L E Rivas J Rivadulla F | 2001 | J Appl Phys2001，89，： | 1 |
| 16 | Removal of boron from geothermal water by a novel boron selective resin 显示文摘 | SANTANDER P RIVAS B L URBANO B F | 2013 | Desalination2013，310，： | 1 |
| 17 | Acute liver injury after intrave- nous amiodarone: A case report 显示文摘 | Verhovei A Elia F Riva A | 2011 | Am J Emerg Med2011，29，7： | 1 |
| 18 | A TiO2/Al2O3 catalyst to improve the ozonation of oxalic acid in water显示文摘 | Rivas F J Ramon M E | 2004 | Appl Catal B:Environ2004，47，： | 1 |
| 19 | Temozoiomide and thalidomide in the treatment of glioblastoma multiforme显示文摘 | Riva M Imbesi F Beghi E | 2007 | Anticancer Res2007，27，2： | 1 |
| 20 | Inhibition of glutathione synthesis in the liver leads to S-adenosyl-L-methionine synthetase reduction显示文摘 | Corrales F Ochoa P Rivas C | 1991 | Hepatology1991，14，3： | 1 |
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