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| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Third genome size category of avian paramyxovirus serotype 1 (Newcastle disease virus) and evolutionary implications显示文摘 | Alíz Czeglédi Dorina Ujvári Eszter Somogyi Enik? Wehmann Ortrud Werner Béla Lomniczi | 2006 | Virus Research2006，，1： | 2 |
| 3 | Improved estimates of cancer-specific survival rates from population-based data显示文摘 | Howlader N Ries LA Mariotto AB | 2010 | J Natl Cancer Inst2010，102，20： | 1 |
| 4 | Brain and other central nervous system cancers: recent trends in incidence and mortality 显示文摘 | Legler JM Ries LA Smith MA | 1999 | J Nail Cancer Inst1999，91，23： | 1 |
| 5 | Annual report to the nation on the status of cancer, 1975-2005, featuring trends in lung cancer, tobacco use, and tobacco control显示文摘 | Jemal A Thun MJ Ries LA | 2008 | J Natl Cancer Inst2008，100，23： | 1 |
| 6 | Pro files of neuronal thread protein expression in Alzhei mefs disease显示文摘 | de la Monte SM Carlson RI Brown NV | 1996 | Journal of Neuropathology and Ex perimental Neurology1996，55，10： | 1 |
| 7 | Towards the identification of biomarkers of transplantation tolerance显示文摘 | Turka LA Lechler RI | 2009 | Nat Rev Immunol2009，9，7： | 1 |
| 8 | Cancer survival and incidence from the Surveillance,Epidemiology,and End Results (SEER) program显示文摘 | Gloeckler Ries LA Reichman ME Lewis DR | 2003 | Oncologist2003，8，： | 1 |
| 9 | Annual report to the nation on the status of cancer,1975-2005,featuring trends in lung cancer,tobacco use,and tobacco control显示文摘 | Jemal A Thun MJ Ries LA | 2008 | J Natl Cancer Inst2008，100，23： | 1 |
| 10 | An analysis of clinical outcomes using color doppler testicular ultrasound for testicular torsion显示文摘 | Baker LA Siqman D Mathews RI | 2000 | Pediatrics2000，105，31： | 1 |
| 11 | An alalysis of clinical Outcomes using color Doppler testicular ultrasound for testicular torsion 显示文摘 | Baker LA Sigman D Mathews RI | 2000 | Pediatrics2000，105，3： | 1 |
| 12 | Annual report to the nation on the status of cancer, 1975-2002, featuring population-based trends in cancer treatment 显示文摘 | Edwards BK Brown ML Wingo PA Howe HL Ward E Ries LA | 2005 | J Natl Cancer Inst2005，97，19： | 1 |
| 13 | Annual report to the nation on the status of cancer,1975-2005,featuring trends in lung cancer,tobacco use,and tobacco control显示文摘 | Jemal A Thun M J Ries LA | 2008 | J Natl Cancer Inst2008，100，23： | 1 |
| 14 | Ananaly sis of clinic out comes using color Doppur testialar ultrasound for testicular torsion显示文摘 | Baker LA Sigman D Mathews RI | 2000 | Pediatrics2000，105，3： | 1 |
| 15 | Annual report to the nation on the status of cancer, 1975 -2005, featuring trends in lung cancer, tobacco use, and tobacco control 显示文摘 | Jemal A Thun MJ Ries LA | 2008 | J Nail Cancer Inst2008，100，23： | 1 |
| 16 | Annual report tothenationon the status of cancer, 1975 - 2005, featuring trends in lung cancer, tobacco use, and tobacco control显示文摘 | Jemal A Thun M J Ries LA | 2008 | J Natl Cancer Ins2008，100，23： | 1 |
| 17 | Comorbidity and age as predictors of risk for early mortality of male and female colon carcinoma patients: a population-based study显示文摘 | Yancik R Wesley MN Ries LA | 1998 | Cancer1998，82，11： | 1 |
| 18 | Cancer surveillance series : brain and other central nervous system cancers: recent trends in incidence and mortality显示文摘 | Legler JM Ries LA Smith MA | 1999 | J Natl Cancer Inst1999，91，： | 1 |
| 19 | An analysis of clinical outcomes using color Doppler testicular ultrasound for testicular torsion显示文摘 | BAKER LA SIGMAN D MATHEWS RI | 2000 | Pediatrics2000，105，： | 1 |
| 20 | An analysis of clinical outcomes using color doppler ultrasound for testicular torsion显示文摘 | Baker LA sigman D Mathews RI | 2000 | Pediatrics2000，105，： | 1 |
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