|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Current databases on biological variation: pros, cons and progress 显示文摘 | Ricos C Alvarez V Cava F | 1999 | Scand J Clin Lab Invest1999，59，： | 1 |
| 3 | Use of Neutral Electrolysed Water (EW) for Quality Maintenance and Shelf-life Extension of Minimally Processed Lettuce显示文摘 | RICO D MARTIN-DIANA A B BARRY-RYAN C | 2008 | Innovative Food Science and Emerging Technologies2008，9，： | 1 |
| 4 | Effect of heat shock on browning-related enzymes in minimally processed iceberg let- tuce and crude extracts显示文摘 | MARTIN-DIANA A H RICO D BARRY-RYAN C | 2005 | Bioscience Biotechnolngy and Biochemistry2005，69，9： | 1 |
| 5 | Polymorphic microsatellite loci in the European rabbit (Oryctolagus cuniculus)are also amplified显示文摘 | Surridge A K Bell D J Rico C | 1997 | Anim Genets1997，28，： | 1 |
| 6 | Interac- tion ofnanoparticles with edible plants and their possi- ble implications in the food chain 显示文摘 | Rico C M Majumdar S Duarte-Gardea M | 2011 | Journal of Agri- cultural and Food Chemistry2011，59，8： | 1 |
| 7 | Current databases on biological variation: pros, cons and progrese 显示文摘 | Ricos C Alvarez V Cava F | 1999 | Scand J Clin Lab Invest1999，59，7： | 1 |
| 8 | Efficacy of steamer jet-injection as alternative to chlorine in fresh- cut lettuce 显示文摘 | Martin-Diana A B Rico D Barry Ryan C | 2007 | Postharvest Biology and Technology2007，45，1： | 1 |
| 9 | Disentangling vector-borne transmission networks:a universal DNA barcoding method to identify vertebrate hosts from arthropod bloodmeals显示文摘 | Alcaide M Rico C | | 0，，： | 1 |
| 10 | The protein kinase Pstoll from traditional rice confers tolerance of phosphorus deficiency显示文摘 | Rico G Y Chin J H Tanaka J P Pesaresi P Catausan S Dalid C Loedin I S Mendoza E M T Wissuwa M Heucr S | 2012 | Nature2012，488，7412： | 1 |
| 11 | Characterisation of solid and liquid fractions of dairy manure with regard to their component distribution and methane production显示文摘 | Rico J L Garcia H Rico C | 2007 | Bioresource Technology2007，98，： | 1 |
| 12 | A study on the lipid components of rice in relation to palatability and storage 显示文摘 | Yoon M R Rico C W Koh H J | 2012 | Journal of the Korean Society for Applied Biological Chemistry2012，55，： | 1 |
| 13 | Yb sensiting of Er3+ up-conversion emission in KGd(WO4)2∶Er, Yb single crystal 显示文摘 | Rico M Pujol M C Mateos X | 2001 | Journal of Alloys and Compounds2001，323，324： | 1 |
| 14 | Quality indicators and specifications for the extra-analytical phases in clinical laboratory management显示文摘 | Ricos C Garcia-Victoria M de-la-Fuente B | 2004 | Clin Chem Lab Med2004，42，6： | 1 |
| 15 | Green tea exlract as a natural antioxidant to extend the shelf-life of flesh-cut lettuce显示文摘 | MARTJ RICO D BARRY-RYAN C | 2008 | Innovative Food Science and Emerging Technologies2008，9，4： | 1 |
| 16 | A population of cholinergic neurons is present in the macaque monkey thalamus显示文摘 | Cavada C | 1998 | Eur J Neurosci1998，10，5： | 1 |
| 17 | Optimisation of steamer jet-injection to extend the shelf-life of fresh-cut lettuce显示文摘 | RICO D MARTIN-DIANA A B BERRY-RYAN C | 2008 | Postharvest Biology and Technology2008，48，3： | 1 |
| 18 | Stock composition North Atlantic populations of whiting using microsatellite markers 显示文摘 | Rico C Ibrahim K M Rico I | 1997 | Journal of Fish Biology1997，51，： | 1 |
| 19 | Approximate cost of theelimination of boron in desalinated water by reverse osmosis andion exchange resins显示文摘 | Ariasd M F C Bru L V Rico D P | 2011 | Desalination2011，273，23： | 1 |
| 20 | Four polymorphic microsatellite loci for the European wild rabbit, Oryctolagus cuniculus 显示文摘 | RICO C RICO I WEBB N | 1994 | Animal Genetics1994，25，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员