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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Gamma knife surgery for mesial temporal lobe epilepsy显示文摘 | Bartolomei F Rey M | 1999 | Epilepsia1999，40，11： | 1 |
| 3 | Detection and titration of neutralizing antibodies to HIV using an inhibition of the cytopathic effect of the virus on MT4 cells 显示文摘 | REY F BARRE - SINOUSSI F SCHMIDTMAYEROVA H | 1987 | J Virol Methods1987，16，： | 1 |
| 4 | Structural biology of hepatitis C virus显示文摘 | Penin F Dubuisson J Rey FA | 2004 | Hepatology2004，39，1： | 1 |
| 5 | Robust power allocation algorithms for MIMO OFDM systems with imperfect CSI显示文摘 | Rey F Lamarca M Vazquez G | 2005 | IEEE Transaction on Signal Processing2005，53，3： | 1 |
| 6 | Purification and properties of two endochitosanases from Mucor rouxii implicated in its cell wall degradation 显示文摘 | Alfonso C Martinez M J Reyes F | 1992 | Fems Microbiology Letters1992，95，23： | 1 |
| 7 | The envelope glycoprotein from tick-borne encephalitis virus at 2A resolution显示文摘 | Rey F A Heinz F X Mandl C | | 0，，： | 1 |
| 8 | Synthesis and structure determination of a new microporous zeolite with large cavities connected by small pores显示文摘 | Herná ndez-Rodrí guez M Jordá J L Rey F | 2012 | J Am Chem Soc2012，134，13： | 1 |
| 9 | Building units design and scale chemistry显示文摘 | Férey G | 2000 | Journal of Solid State Chemistry2000，152，： | 1 |
| 10 | Comparative study of the expression of metalloproteases and their inhibitors in different localizations within primary tumours and in metastatic lymph nodes of breast cancer显示文摘 | GARCA M F GONZ(A)LEZ REYES S GONZLEZ L O | 2010 | Int J Exp Pathol2010，91，4： | 1 |
| 11 | Concerning the significance of paraoxonase-1 and SR-B1 genes in atherosclerosis显示文摘 | Rodríguez Esparragón F Hernández Trujillo Y Macías Reyes A | 2006 | Rev Esp Cardiol2006，59，2： | 1 |
| 12 | Successful tocilizumab treatment in a child with refractory Takayasu arteritis显示文摘 | Bravo Mancheno B Perm F Guez Vazquez Del Rey Mdel M | 2012 | Pediatrics2012，130，： | 1 |
| 13 | A new microporous zeolitic silicoborate(ITQ-52) with interconnected small and medium pores显示文摘 | Simancas R Jordá J L Rey F | 2014 | J Am Chem Soc2014，136，9： | 1 |
| 14 | Steady state segregation and heat flow in ESR 显示文摘 | Ridder S D Reyes F C Chakravorty S | 1978 | Metall Trans: B1978，9，4： | 1 |
| 15 | Translocation of soils to stimulate climate change: CO2 emissions and modifications to soil organic matter 显示文摘 | Rey M Guntinas E Gil - sotres F | 2007 | European Journal of Soil Science2007，10，： | 1 |
| 16 | Productive Infection of CD4 + Cells by Selected HIV Strains is not Inhibited by Anti - CD4 Monoclonal Antibodies 显示文摘 | REY F DONKER G HIRSCH I | 1991 | Virology1991，181，： | 1 |
| 17 | Dexarnethasone in- hibits BAFF expression in fibroblast-like synoviocytes from patients with rheumatoid arthritis显示文摘 | Reyes LI Leon F Gonzalez P | 2008 | Cytokine2008，42，2： | 1 |
| 18 | Contribu- tions of vegetation cover and cattle hoof prints towards seed runoff control on ski pistes显示文摘 | Isselin-Nondedeu F Rey F Bedecarrats A | 2006 | Ecological Engi-neering2006，27，3： | 1 |
| 19 | Gamma knife surgery for mesial temporal lobe epilepsy 显示文摘 | Regis J Bartolomei F Rey M | 2000 | J Neurosurg2000，93，3： | 1 |
| 20 | Localization of TREK-1,a two-pore-domain K^+ channel in the peripheral vestibular system of mouse and rat显示文摘 | Nicolas MT Lesage F Reyes R | 2004 | Brain Res2004，1017，12： | 1 |
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