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| 1 | Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone mass显示文摘Background Ethnicity is shown to be one of important factors affacting bone mineral density (BMD). The present study was performed to compare the association of six markers for five candidate genes with BMD variation in two populations of different ethnicity, Caucasian and Chinese, and the contribution of genotype and ethnicity to this variation in the populations.Methods The studied restriction fragment length polymorphisms were Bsa H Ⅰ of the calcium-sensing receptor gene, Sac Ⅰ of the α2HS-glycoprotein (AHSG) gene, Pvu Ⅱ and Xba Ⅰ of the oestrogen receptor α gene, Apa Ⅰ of the vitamin D receptor (VDR) gene and BstB Ⅰ of the parathyroid hormone gene. The association of these markers with BMD was analysed by one-way and two-way ANOVA with adjustment for covariates. Results Two polymorphisms, AHSG- Sac Ⅰ and VDR- Apa Ⅰ, showed no association with BMD, while the others were associated with BMD variation at some skeletal sites in either males or females. The polymorphisms indicated clear distinctions between the associations depending on ethnicity, gender and skeletal site. Similar patterns were observed in their contribution to the total population BMD variation. Ethnicity appears to have a larger effect on the total population BMD variation in females than in males. It may account, on the average, for about 2% total population BMD variation at the spine of females and about 1% at the hip of males and females. Conclusion The results of the present study suggest that significant interethnic differentiation at some loci may contribute to the significant interethnic difference in BMD. However, this contribution apparently is not large. | Volodymyr Dvornyk LIU Peng-yuan LONG Ji-rong ZHANG Yuan-yuan LEI Shu-feng Robert R Recker DENG Hong-wen | 2005 | Chinese Medical Journal2005，，15： | 2 |
| 2 | Calcium intake and body weight显示文摘 | DAVIES K M HEANEY R P RECKER R R | 2000 | Journal of Clinical Endocrinology and Metabolism2000，85，： | 2 |
| 3 | Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients显示文摘 | Recker R Lappe J Davies KM | 2004 | J Bone Miner Res2004，19，10： | 1 |
| 4 | Rodent neonatal bilateral carotid artery occlusion with hypoxia mimics human hypoxic ischemic injury显示文摘 | Recker R Adami A Tone B | 2009 | J Cereb Blood Flow Metab2009，29，： | 1 |
| 5 | Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli:a clinical trial assessing compliance,efficacy,and safety显示文摘 | Rubin C Recker R Cullen D | 2004 | J Bone Miner Res2004，19，3： | 1 |
| 6 | A randomized,double-blind phase 2clinical trial of blosozumab,a sclerostin antibody,in postmenopausal women with low bone mineral density显示文摘 | RECKER R R BENSON C T MATSUMOTO T | 2015 | J Bone Miner Res2015，30，2： | 1 |
| 7 | Intravenous- zoledronic acid 5 mg in the treatment of postmenopausal women with low bone density previously treated with alendronate显示文摘 | McClung M Recker R Miller P | 2007 | Bone2007，41，1： | 1 |
| 8 | Comparative effects of teriparatide and strontium ranelate on bone biopsisies and biochemical markers of bone turnover in postmenopausal women with osteoporosis显示文摘 | Recker R R Marin F Ish-Shalon S | 2009 | J Bone Miner Res2009，24，8： | 1 |
| 9 | Effect of dosing frequency on bisphosphonate medication ad- herence in a large longitudinal cohort of women显示文摘 | Recker RR Gallagher R MacCosbe PE | 2005 | Mayo Clin Proc2005，80，7： | 1 |
| 10 | Intravenous zoledronic acid 5 mg in thetreatment of postmenopausal women with low bone density previously treated with alendronate 显示文摘 | McClung M Recker R Miller P | 2007 | Bone2007，41，1： | 1 |
| 11 | Characterization of peri-menopausal bone loss:a prospective study显示文摘 | Recker R Lappe J Daview K | 2000 | Journal of Bone and Mineral Research2000，15，： | 1 |
| 12 | Long-term raloxifene for postmenopausal osteoporosis显示文摘 | Recker R R Mitlak B H Ni X | 2011 | Curr Med Res Opin2011，27，9： | 1 |
| 13 | Fragment size difference between multiplex and singleplex PCR products and their practive 显示文摘 | Zhou W Recker R | 2000 | Biotechniques2000，29，2： | 1 |
| 14 | Effect of dosing frequency on bisphosphonates medication adherence in a large longitudinal cohort of women显示文摘 | Recker R GallaghcrR Mac Cosbe P | 2005 | Mayo Clin Proc2005，80，7： | 1 |
| 15 | Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety 显示文摘 | Rubin C Recker R Cullen D | 2004 | J Bone Miner Res2004，19，3： | 1 |
| 16 | Operative techniques and strategies for minimally invasive fetoscopic fetal cardiac interventions in sheep 显示文摘 | Kohl T Witteler R Stumper D Gogarten W Asfour B Reckers J | 2000 | Surg Endosc2000，14，5： | 1 |
| 17 | Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli : a clinical trial assessing compliance, efficacy,and safety显示文摘 | Clinton R Recker R Cullen D | 2004 | Bone Miner Res2004，19，3： | 1 |
| 18 | Effects ofintravenous zoledronic acid once yearly on boneremodeling and bone structure 显示文摘 | Recker R R Delmas P D Halse J et a1 | 2008 | Bone Miner Res2008，23，1： | 1 |
| 19 | Prevention of postmenopausat bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety 显示文摘 | Rubin C Recker R Cullen D | 2004 | J Bone Miner Res2004，19，： | 1 |
| 20 | Proteomics in bone research显示文摘 | Zhang H Recker R Xiao G | 2010 | Expert Rev Proteomics2010，7，1： | 1 |
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