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| 1 | D-MELD risk capping improves post-transplant and overall mortality under markov microsimulation显示文摘AIM: To hypothesize that the product of calculated Model for End-Stage Liver Disease score excluding exception points and donor age(D-MELD) risk capping ± Rule 14 could improve post liver transplant and overall survival after listing.METHODS: Probabilities derived from the United Network for Organ Sharing database between 2002 and 2004 were used to simulate potential outcomes for all patients listed for transplantation. The Markov simula-tion was then modified by screening matches using a 1200 or 1600 D-MELD risk cap ± allowing transplants for Model for End-Stage Liver Disease(MELD) ≤ 14(Rule 14). The differential impact of the rule changes was assessed.RESULTS: The Markov simulation accurately reproduced overall and post transplant survival. A 1200 D-MELD risk cap improved post-transplant survival. Both the 1200 and 1600 risk caps improved overall survival for waitlisted patients. The addition of Rule 14 further improved post transplant and overall survival by redistribution of donor livers to recipients in higher MELD subgroups. The mechanism for improved overall and post-transplant survival after listing was due to shifting a larger percentage of transplants to the moderate MELD score subgroup(MELD 15-29) while also ensuring that high MELD recipients have livers of high quality to achieve excellent post transplant survival.CONCLUSION: A 1200 D-MELD risk cap + Rule 14 provided the greatest overall benefit primarily by focusing liver transplantation towards the moderate MELD recipient. | Jeffrey B Halldorson Robert L Carithers Jr Renuka Bhattacharya Ramasamy Bakthavatsalam Iris W Liou Andre A Dick Jorge D Reyes James D Perkins | 2014 | World Journal of Transplantation2014，4，3： | 2 |
| 2 | Heart failure in COVID-19 patients:Critical care experience显示文摘Patients with heart failure(HF)may be at a higher risk of coronavirus disease 2019(COVID-19)infection and may have a worse outcome due to their comorbid conditions and advanced age.In this narrative review,we aim to study the interaction between COVID-19 and HF from a critical care perspective.We performed a systematic search for studies that reported HF and critical carerelated outcomes in COVID-19 patients in the PubMed and Medline databases.From a total of 1050 papers,we identified 26 that satisfied the eligibility criteria for our review.Data such as patient demographics,HF,intensive care unit(ICU)admission,management,and outcome were extracted from these studies and analyzed.We reported outcomes in heart-transplant patients with COVID-19 separately.In hospitalized patients with COVID-19,the prevalence of HF varied between 4%and 21%.The requirement for ICU admission was between 8%and 33%.HF patients with COVID-19 had an overall mortality rate between 20%and 40%.We identified that HF is an independent predictor of mortality in hospitalized COVID-19 patients,and patients with HF were more likely to require ventilation,ICU admission and develop complications.Patients with HF with reduced ejection fraction did worse than those with HF with midrange ejection fraction,and HF with preserved ejection fraction.COVID-19 patients with HF should be identified early and managed aggressively in an attempt to improve outcomes in this cohort of patients. | Kevin John John Ajay K Mishra Chidambaram Ramasamy Anu A George Vijairam Selvaraj Amos Lal | 2022 | World Journal of Virology2022，11，1： | 1 |
| 3 | Learning the lessons from conflict:pre-hospital cervical spine stabilization following ballistic neck trauma显示文摘 | Ramasamy A Midwinter M Mahoney P | 2009 | Injury2009，12，40： | 1 |
| 4 | Molecular changesfrom dysplastic nodule to hepatocellular carcinoma throughgene expression profiling显示文摘 | Nam S W Park J Y Ramasamy A | 2005 | Hepatology2005，42，4： | 1 |
| 5 | Use of aquatic weed salvinia as full partial feed in commercial digesters显示文摘 | ABBASI S A NIPANEY P C RAMASAMY E V | 1992 | Indian J Technol1992，30，： | 1 |
| 6 | Dysregulation of Complement System and CD4+ T Cell Activation Pathways Implicated in Allergic Response显示文摘 | Couto Alves A Bruhn S Ramasamy A | 2013 | PLo S One2013，8，74： | 1 |
| 7 | Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone显示文摘 | Kusumbe A P Ramasamy S K Adams R H | 2014 | Nature2014，507，7492： | 1 |
| 8 | Receptor for AGE (RAGE) : signaling mechanisms in the pathogenesis of diabetes and its complications 显示文摘 | Ramasamy R Yah S F Schmidt A M | 2011 | Ann N Y Acad Sci2011，1243，： | 1 |
| 9 | Degree of crosslinking of collagen at interfaces: Adhesion and shear rheological indicators显示文摘 | Fathima N N Dhathathreyan A Ramasami T | 2011 | International Journal of Biological Macromolecules2011，48，： | 1 |
| 10 | Digital signature scheme with message recovery using knapsack-based ECC显示文摘 | Ramasamy R R Prabakar M A | 2011 | International Journal of Network Security2011，12，1： | 1 |
| 11 | Hydrogen production from used lubri- cating oils 显示文摘 | Ramasamy K K T-Raissi A | 2007 | Catalysis Today2007，129，： | 1 |
| 12 | The receptor for advanced glycation endproducts (RAGE) and cardiovasular disease显示文摘 | YAN S F RAMASAMY R SCHMIDT A M | 2009 | Expert Rev Mol Med2009，11，： | 1 |
| 13 | Vermicomposting of different forms of water hyacinth by the earthworm Eudrilus eugeniae, Kinberg 显示文摘 | Gajalakshmi S Ramasamy E V Abbasi S A | 2002 | Bioresouree Technology2002，，82： | 1 |
| 14 | Immunogenicity of a malaria parasite antigen displayed by Lactococcus lactis in oral immunizations显示文摘 | Ramasamy R Yasawardena S Zomer A | 2006 | Vaccine2006，24，18： | 1 |
| 15 | Vitiquinolone-A quinolone al- kaloid from Hibiscus vitifolius Linn 显示文摘 | Ramasamy D Saraswathy A | 2014 | Food chemistry2014，145，： | 1 |
| 16 | Trends in α-hole Strengths and Interactions of F3 MX Molecules (M=C,Si,Ge and X=F,C1,Br,I)显示文摘 | BUNDHUN A RAMASAMI P MURRAY J S | 2013 | J Mol Model2013，19，7： | 1 |
| 17 | Isola- tion and identification of antibacterial and cytotoxic compounds from the leaves of Muntingia calabura L显示文摘 | Sufian A S Ramasamy K Ahmat N | 2013 | Journal of Ethnopharmacology2013，146，2： | 1 |
| 18 | Clay mineralogy of the Late Cretaceous and early Tertiary successions of the Cauvery Basin ( southeastern India) : implications for sediment source and palaeoclimates at the K/T boundary 显示文摘 | Madhavaraju J Ramasamy S Ruffell A | 2002 | Cretaceous Research2002，23，： | 1 |
| 19 | Vermicomposting of different forms of water hyacinth by earthworm Eudrilus eugeniae, Kinberg显示文摘 | Gajalakshmi S Ramasamy E V Abbasi S A | 2002 | Biores Technol2002，82，2： | 1 |
| 20 | Successful treatment of refractory angioimmunoblastic T-cell lymphoma with thalidomide and dexamethasone 显示文摘 | Ramasamy K Lira Z Pagliuca A | 2006 | Haematologiea2006，91，8： | 1 |
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