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| 1 | Starting glargine in insulin-nave type 2 diabetic patients based on body mass index is safe显示文摘AIM:To evaluate the safety of four insulin titration algorithms in a homogeneous population of insulin-na ve type 2 diabetic patients.METHODS:We conducted a 24-wk,open,single-center study with 92 insulin-na ve type 2 diabetes patients who failed treatment with one or two oral drugs.The patients were randomized to one of the four following algorithms:LANMET(n=26)and LANMET PLUS(n=22)algorithms,whose patients received a fixed initial insulin dose of 10 U,and DeGold(n=23)and DeGold PLUS(n=21)algorithms,whose patients’initial insulin dose was based on their body mass index(BMI).In addition,patients in the PLUS groups had their insulin titrated twice a week from 2 to 8 U.In the other two groups,the titration was also performed also twice a week,but in a fixed increments of 2 U.The target fasting glucose levels for both groups was 100 mg/dL.RESULTS:There was no significant difference in efficacy parameters.There was no significant difference when comparing moderate hypoglycemia events in algorithms starting with a 10 U fixed dose and algorithms based on BMI.However,there was a significant increase in moderate hypoglycemia events among the PLUS treated patients when the LANMET and DeGold algorithms were compared with the 2 fast-titration PLUS algorithms.We observed 12 hypoglycemia events in the first group,which corresponded to 0.94 events/patient per year,and we observed 42 events in the second group,which corresponded to 2.81 events/patient per year(P<0.037).No further significant differences were observed when other comparisons between the algorithms were carried out.CONCLUSION:Starting insulin glargine based on BMI is safe,but fast titration algorithms increase the risk of moderate hypoglycemia. | Denise R Franco Juliana Baptista Fatima RM Abreu Risoneide B Batista Freddy G Eliaschewitz | 2014 | World Journal of Diabetes2014，5，1： | 2 |
| 2 | Anti-tumor necrosis factor α therapy associates to type 17 helper T lymphocytes immunological shift and significant microbial changes in dextran sodium sulphate colitis显示文摘BACKGROUND Anti-tumor necrosis factor α(TNFα) represents the best therapeutic option to induce mucosal healing and clinical remission in patients with moderate-severe ulcerative colitis. On the other side gut microbiota plays a crucial role in pathogenesis of ulcerative colitis but few information exists on how microbiota changes following anti-TNFα therapy and on microbiota role in mucosal healing.AIM To elucidate whether gut microbiota and immune system changes appear following anti TNFα therapy during dextran sulfate sodium(DSS) colitis.METHODS Eighty C57 BL/6 mice were divided into four groups: 'No DSS', 'No DSS + antiTNFα', 'DSS' and 'DSS + anti-TNFα'. 'DSS' and 'DSS + anti-TNFα' were treated for 5 d with 3% DSS. At day 3, mice whithin 'No DSS+anti-TNFα' and'DSS+anti-TNFα' group received 5 mg/kg of an anti-TNFα agent. Forty mice were sacrificed at day 5, forty at day 12, after one week of recovery post DSS. The severity of colitis was assessed by a clinical score(Disease Activity Index), colon length and histology. Bacteria such as Bacteroides, Clostridiaceae, Enterococcaceae and Fecalibacterium prausnitzii(F. prausnitzii) were evaluated by quantitative PCR.Type 1 helper T lymphocytes(Th1), type 17 helper T lymphocytes(Th17) and CD4+ regulatory T lymphocytes(Treg) distributions in the mesenteric lymph node(MLN) were studied by flow cytometry.RESULTS Bacteria associated with a healthy state(i.e., such as Bacteroides, Clostridiaceae and F. prausnitzii) decreased during colitis and increased in course of anti-TNFαtreatment. Conversely, microorganisms belonging to Enterococcaceae genera,which are linked to inflammatory processes, showed an opposite trend.Furthermore, in colitic mice treated with anti-TNFα microbial changes were associated with an initial increase(day 5 of the colitis) in Treg cells and a consequent decrease(day 12 post DSS) in Th1 and Th17 frequency cells. Healthy mice treated with anti-TNFα showed the same histological, microbial and immune features of untreated colitic mice. 'No DSS + anti-TNFα' group showed a lymphomononuclear infiltrate both at 5 th and 12 th d at hematoxylin and eosin staining, an increase of in Th1 and Th17 frequency at day 12, an increase of Enterococcaceae at day 5, a decrease of Bacteroides and Clostridiaceae at day 12.CONCLUSION Anti-TNFα treatment in experimental model of colitis improves disease activity but it is associated to an increase in Th17 pathway together with gut microbiota alteration. | Valentina Petito Cristina Graziani Loris R Lopetuso Marco Fossati Alessandra Battaglia Vincenzo Arena Domenico Scannone Gianluca Quaranta Andrea Quagliariello Federica Del Chierico Lorenza Putignani Luca Masucci Maurizio Sanguinetti Alessandro Sgambato Antonio Gasbarrini Franco Scaldaferri | 2019 | World Journal of Gastroenterology2019，25，12： | 2 |
| 3 | PCNA in the testis of the frog, Rana esculenta; A molecular marker of the mitotic testicular epithelium proliferation显示文摘 | Paolo C Franco R Fulgione D | 2000 | General and Comparative Endocrinology2000，119，： | 1 |
| 4 | The role of CD133 in the identification and characterisation of tumour-initiating cells in non-small-cell lung cancer显示文摘 | Tirino V Camerlingo R Franco R | 2009 | Eur J Cardiothorac Surg2009，36，3： | 1 |
| 5 | System Oriented Har-monic-Balance Algorithms for Circuit-Level Simulation 显示文摘 | Vittorio R Diego M Franco M | 2011 | Computer- Aided Design of Integrated Circuits and Sys-tems IEEE Transactions2011，30，2： | 1 |
| 6 | Diagnosis of pulmonary sequestration by spiral CT angiography 显示文摘 | Aliaga R Domingo ML | 1998 | Thorax1998，53，12： | 1 |
| 7 | Structure of NiCrAlY coatings deposited on single-crystal alloy turbine blade material by laser cladding 显示文摘 | VILAR R SANTOS E C FERREIRA P N FRANCO N DA SILVA | 2009 | Acta Materialia2009，57，18： | 1 |
| 8 | The role of CD133 in the identification and characterisation of tumourinitiating cells in non-small-cell lung cancer 显示文摘 | Tirino V Camerlingo R Franco R | 2009 | Eur J Cardiothorac Surg2009，36，3： | 1 |
| 9 | Viscosity measurement of newtonian liquids using the complex reflec- tion coefficient显示文摘 | Franco E E Adamowski J C Higuti R T | 2008 | IEEE Transactions on Ultrasonic Ferro- electrics and Frequency Control2008，55，10： | 1 |
| 10 | Cryptococcal me ningoencephalitis and pulmonary noduleinnon-HIV-infecte- dimmunoeompetentpatient 显示文摘 | Lambertucci JR Franco R de Queiroz LC | 2005 | Rev Soc Bras Med Trop2005，38，2： | 1 |
| 11 | Over expression of both CXC chemokine receptor 4 and vascular endothelial growth factor proteins predicts early distant relapse in stage Ⅱ-Ⅲ colorectal cancer patients显示文摘 | Ottaiano A Franco R Talamanca A | 2006 | Clin Cancer Res2006，12，9： | 1 |
| 12 | Microstructured-core optical fibre for evanescent wave gas sensing显示文摘 | Cordeiro C M B Franco M A R Chesinil G | 2006 | Optics Express2006，14，13： | 1 |
| 13 | Effect of experimental conditions on cogasification of coal,biomass and plastics wastes with air/steam mixtures in a fluidized-bed system显示文摘 | PINTO F FRANCO C ANDRE R TAVARES C DIAS M GULYURTLU I CABRITA I | 2003 | Fuel2003，82，1517： | 1 |
| 14 | Diagnosis of pulmonary sequestration by spiral CT angiography显示文摘 | Franco J Aliaga R Domingo ML | 1998 | Thorax1998，53，： | 1 |
| 15 | Azacitidine adverse effects in patients with myelodysplastic syndromes 显示文摘 | San Miguel Amigo L Franco Osorio R Mercadal Vilchez S | 2011 | AdvTher2011，28，14： | 1 |
| 16 | A'live'biopsy in a smallcell lung cancer patient by detection of circulating tumor cells显示文摘 | Bevilacgua S Gallo M Franco R | 2009 | Lung Cancer2009，65，1： | 1 |
| 17 | Salted and fermented fish processes evaluation 显示文摘 | Pombo C R Marsico E T Franco R M | 2009 | International Journal of Food Science & Technology2009，44，11： | 1 |
| 18 | Oxdative stress, DNA methylation and carcinogenesis显示文摘 | Franco R Schnoeveld O Georgakilas AG | 2008 | Cancer2008，25，： | 1 |
| 19 | A secreted form of ADAM9 promotes carcinoma invation through tumor-stromal interac- tions显示文摘 | Mazzocca A Coppari R De Franco R | 2005 | Cancer Res2005，65，11： | 1 |
| 20 | Comparison of diagnositi accuracy of sublingual nitroglyc erin test and low dose isoproterenol test in patients with unexplained syncope显示文摘 | Antonio R Franco G Michele B | 2000 | Am J Cardiol2000，85，： | 1 |
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