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| 1 | Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease (NAFLD) is an increasingly recognized cause of liver-related morbidity and mortality. It can develop secondary to numerous causes but a great majority of NAFLD cases occur in patients who are obese or present with other components of metabolic syndrome (hypertension, dyslipidemia, diabetes). This is called primary NAFLD and insulin resistance plays a key role in its pathogenesis. Obesity is characterized by expanded adipose tissue, which is under a state of chronic inflammation. This disturbs the normal storage and endocrine functions of adipose tissue. In obesity, the secretome (adipokines, cytokines, free fatty acids and other lipid moieties) of fatty tissue is amplified, which through its autocrine, paracrine actions in fat tissue and systemic effects especially in the liver leads to an altered metabolic state with insulin resistance (IR). IR leads to hyperglycemia and reactive hyperinsulinemia, which stimulates lipid-accumulating processes and impairs hepatic lipid metabolism. IR enhances free fatty acid delivery to liver from the adipose tissue storage due to uninhibited lipolysis. These changes result in hepatic abnormal fat accumulation, which may initiate the hepatic IR and further aggravate the altered metabolic state of whole body. Hepatic steatosis can also be explained by the fact that there is enhanced dietary fat delivery and physical inactivity. IR and NAFLD are also seen in various lipodystrophic states in contrary to popular belief that these problems only occur due to excessive adiposity in obesity. Hence, altered physiology of adipose tissue is central to development of IR, metabolic syndrome and NAFLD. | Kamran Qureshi Gary A Abrams | 2007 | World Journal of Gastroenterology2007，13，26： | 52 |
| 2 | Aggressive blood pressure treatment of hypertensive intracerebral hemorrhage may lead to global cerebral hypoperfusion:Case report and imaging perspective显示文摘Hypoperfusion injury related to blood pressure decrease in acute hypertensive intracerebral hemorrhage continues to be a controversial topic. Aggressive treatment is provided with the intent to stop the ongoing bleeding. However, there may be additional factors, including autoregulation and increased intracranial pressure, that may limit this approach. We present here a case of acute hypertensive intracerebral hemorrhage, in which aggressive blood pressure management to levels within the normal range led to global cerebral ischemia within multiple border zones. Global cerebral ischemia may be of concern in the management of hypertensive hemorrhage in the presence of premorbid poorly controlled blood pressure and increased intracranial pressure. | Jose Gavito-Higuera Rakesh Khatri Ihtesham A Qureshi Alberto Maud Gustavo J Rodriguez | 2017 | World Journal of Radiology2017，9，12： | 49 |
| 3 | Minimally invasive procedures on the lumbar spine显示文摘Degenerative disease of the lumbar spine is a common and increasingly prevalent condition that is often implicated as the primary reason for chronic low back pain and the leading cause of disability in the western world. Surgical management of lumbar degenerative disease has historically been approached by way of open surgical procedures aimed at decompressing and/or stabilizing the lumbar spine. Advances in technology andsurgical instrumentation have led to minimally invasive surgical techniques being developed and increasingly used in the treatment of lumbar degenerative disease. Compared to the traditional open spine surgery, minimally invasive techniques require smaller incisions and decrease approach-related morbidity by avoiding muscle crush injury by self-retaining retractors, preventing the disruption of tendon attachment sites of important muscles at the spinous processes, using known anatomic neurovascular and muscle planes, and minimizing collateral soft-tissue injury by limiting the width of the surgical corridor. The theoretical benefits of minimally invasive surgery over traditional open surgery include reduced blood loss, decreased postoperative pain and narcotics use, shorter hospital length of stay, faster recover and quicker return to work and normal activity. This paper describes the different minimally invasive techniques that are currently available for the treatment of degenerative disease of the lumbar spine. | Branko Skovrlj Jeffrey Gilligan Holt S Cutler Sheeraz A Qureshi | 2015 | World Journal of Clinical Cases2015，3，1： | 8 |
| 4 | Intracerebral haemorrhage显示文摘 | Adnan I Qureshi A David Mendelow Daniel F Hanley | 2009 | The Lancet . 2009 (9675)2009，，9675： | 3 |
| 5 | Perioperative outcomes in minimally invasive lumbar spine surgery: A systematic review显示文摘AIM: To compare minimally invasive(MIS) and open techniques for MIS lumbar laminectomy, direct lateral and transforaminal lumbar interbody fusion(TLIF) surgeries with respect to length of surgery, estimated blood loss(EBL), neurologic complications, perioperative transfusion, postoperative pain, postoperative narcotic use, and length of stay(LOS).METHODS: A systematic review of previously published studies accessible through Pub Med was performed. Only articles in English journals or published with English language translations were included. Level of evidence of the selected articles was assessed. Statistical data was calculated with analysis of variance with P < 0.05 considered statistically significant.RESULTS: A total of 11 pertinent laminectomy studies, 20 direct lateral studies, and 27 TLIF studies were found. For laminectomy, MIS techniques resulted in a significantly longer length of surgery(177.5 min vs 129.0 min, P = 0.04), shorter LOS(4.3 d vs 5.3 d, P = 0.01) and less perioperative pain(visual analog scale: 16 ± 17 vs 34 ± 31, P = 0.04). There is evidence of decreased narcotic use for MIS patients(postoperative intravenous morphine use: 9.3 mg vs 42.8 mg), however this difference is of unknown significance. Direct lateral approaches have insufficient comparative data to establish relative perioperative outcomes. MIS TLIF had superior EBL(352 mL vs 580 mL, P < 0.0001) and LOS(7.7 d vs 10.4 d, P < 0.0001) and limited data to suggest lower perioperative pain.CONCLUSION: Based on perioperative outcomes data, MIS approach is superior to open approach for TLIF. For laminectomy, MIS and open approaches can be chosen based on surgeon preference. For lateral approaches, there is insufficient evidence to find noninferior perioperative outcomes at this time. | Branko Skovrlj Patrick Belton Hekmat Zarzour Sheeraz A Qureshi | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 6 | Bowel perforation due to break and distal passage of the safety ring of an adjustable intra-gastric balloon: A potentially life threatening situation显示文摘A 45-year-old man of Middle Eastern origin, morbid obese, with a body mass index of 39 had an intragastric balloon, filled with 500 mL of saline/methylene blue and intended as definite therapy, inserted some8 wk previously. He was admitted to the emergency department with abdominal cramps. An ultrasound of the abdomen was performed in ER which confirmed the balloon to be in place without any abnormality.He was discharged home on symptomatic medication.Patient remains symptomatic therefore he reported back to ER 2 d later. Computed tomography scan was performed this time for further evaluation which revealed a metallic ring present in the small bowel while the intra-gastric balloon was in its proper position.There was no clinical or radiological sign of intestinal obstruction. Patient was hospitalized for observation and conservative management. The following night,patient experienced sudden and severe abdominal pain, therefore an X-ray of the abdomen in erect position was done, which showed free air under the right dome of diaphragm. Patient was transferred to O.R for emergency laparotomy. There were two small perforations identified at the site of the metallic ring entrapment. The ring was removed and the perforations were repaired. Due to increasing prevalence of obesity and advances in modalities for its management,physicians should be aware of treatment options, their benefits, complications and clinical presentation of the known complications. Physicians need to be updated to approach these complications within time, to avoid lifethreatening situations caused by these appliances. | Ali M Al-Zubaidi Hassan U Alghamdi Abdu H Alzobydi Irshad A Dhiloon Laeeque A Qureshi | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，4： | 3 |
| 7 | Spontaneous Intracerebral Hemorrhage显示文摘 | Qureshi A I Tuhrim S Broderick J P | 2001 | N Engl J Med2001，344，19： | 2 |
| 8 | l Frequency and determi-nants of postprocedural hemodynamic instability after carotid angio-plasty and stenting显示文摘 | Qureshi AI Luft AR SharmaM et a | 1999 | Stroke1999，30，： | 1 |
| 9 | Inflammation,Malnutrition,and Cardiac Disease as Predictors of Mortality in Hemodialysis Patients显示文摘 | Qureshi AR Alvestrand A | 2002 | J Am Soc Nephrol2002，13，： | 1 |
| 10 | Determination of clenbuterol and mabuterol in equine plasma by ion-pair liquid chromatography with electrochemical detection 显示文摘 | Qureshi G A Eriksson A | 1998 | J Chromatogr1998，441，： | 1 |
| 11 | Fusarium proliferatum culture material alters severa; production and immune performance parameters in white Leghorn chickens显示文摘 | Qureshi M A Garlieh J D Hagler W M | 1995 | Immunopharmacol-Immunotoxicol1995，17，4： | 1 |
| 12 | Effects of high copper supplements on performance, health, plasma copper and enzymes in goats显示文摘 | Solaiman S G Maloney M A Qureshi M A Davis G D'Andrea G | 2001 | Small Ruminant Research2001，41，2： | 1 |
| 13 | Abdominal aortic aneurysm surgery in a district general hospital: a 15-year experience 显示文摘 | Qureshi NA Rehman A Slater N | 2007 | Ann Vasc Surg2007，21，6： | 1 |
| 14 | Intracranial angioplasty and stent placement after stenting and aggressive medical management for preventing recurrent stroke in intraeranial stenosis (SAMMPRIS) trial: present state and future considerations 显示文摘 | Qureshi A I AI-Senani F M Husain S | 2012 | J Neuroimaging2012，22，1： | 1 |
| 15 | First re-port on the biodiversity of Khunjerab National Park,Pakistan 显示文摘 | Qureshi R Khan W A Bhatti G R | 2011 | Pakistan Journal of Botany2011，43，2： | 1 |
| 16 | Recurrent miscarriage 显示文摘 | DuckittK Qureshi A | 2011 | Cli-nEvid ( Online)2011，，： | 1 |
| 17 | Comparison of public key authority and token based registration approach 显示文摘 | Haseeb K Bakar K A Qureshi K N | 2013 | World Applied Sciences Journal2013，23，6： | 1 |
| 18 | Mono - segment fixation of thoracolumbar burst fractures 显示文摘 | Perera A Qureshi A Brecknell JE | 2015 | Br J Neurosur2015，29，3： | 1 |
| 19 | Hy-brid silica membranes with enhanced hydrogen and CO2seParation ProPerties显示文摘 | Castricum H L Qureshi H F Nijmeijer A | 2015 | J Membr Sci2015，488，15： | 1 |
| 20 | Non-dysraphic intramedullary spinal cord lipoma显示文摘 | Qureshi NA Akram M Ghaffar A | 2006 | J Coil Physicians Surg Pak2006，16，4： | 1 |
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