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666篇 您的检索式:作者名="Prowse"
    题名 作者 年代 出处 被引量
1WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics显示文摘有干细胞特征的前列腺癌症房间被他们在非支持者文化从单个房间形成自我更新的 prostaspheres 的能力在人的前列腺癌症房间线识别。Prostaspheres 展出了增长,区别和茎的异构的表示联系房间的制造者 CD44, ABCG2 和 CD133。有 WNT 禁止者的治疗减少了 prostasphere 尺寸和自强。相反,引起的 Wnt3a 的增加增加了 prostasphere 尺寸和自强,它与原子尾 - catenin 的重要增加被联系,角质素 18, CD133 和 CD44 表示。作为 LNCaP 和 C4-2B 癌症房间快车雄激素受体的一个高比例,我们决定了雄激素受体对手 bicalutamide 的效果。雄激素受体抑制减少了 prostasphere 尺寸和 PSA 的表示,但是没禁止 prostasphere 形成。这些效果与有干细胞特征和放大房间的运输的雄激素依赖者增长的房间的雄激素无关的自强一致。作为发信号的受动器尾 - catenin 能也与雄激素受体联系的正规 WNT,我们为包含在 WNT 和雄激素受体活动之间的平衡的瘤繁殖建议一个模型。那将与干细胞特征和开车运输放大房间增长和区别影响一个癌症房间的自强。在结论,我们提供那项 WNT 活动独立于雄激素受体活动与干细胞特征调整前列腺癌症房间的自强的证据。WNT 发信号的抑制因此有潜力与干细胞特征减少前列腺癌症房间的自强并且改进治疗学的结果。Isabelle Bisson David M Prowse 2009Cell Research2009,,6:37
2The effect of river-ice breakup on suspended sediment and select trace--element fluxes显示文摘Milburn D Prowse T D 1996Nordic Hydrology1996,27,12:1
3Specific association of human telomerase activity with immortal cells and cancer显示文摘KIM N W PLATYSZEK M A PROWSE K R 1994Science1994,266,5193:1
4Specific association of human telomerase activity with immortal cells and cancer 显示文摘Kim NW Piatyszek MA Prowse KR 1994Science1994,266,5193:1
5Molecular genetic evidence that endometriosis is a precursor of ovarian cancer显示文摘Prowse AH Manek S Varma R 2006Int J Cancer2006,119,3:1
6Specific association of human telomerase activity with immortal cell and cancer显示文摘 Piatyszek MA Prowse KR 1994Science1994,266,5193:1
7Specific association of human telomerase activity with immortal cells and cancer显示文摘Kim NW Piatyszek MA Prowse KR 1994Science1994,266,5193:1
8Specific association of human telomerase activity with immortal cells and cell显示文摘Kim NM Piatyszek MA Prowse KR 1994Science1994,266,:1
9Specific association of human telomerase activity with immortal cells and cancer显示文摘Kim JL Piatyxzek MA Prowse K R 1994Science1994,266,:1
10Molecular genetic evidencethat endometriosis is a precursor of ovarian cancer显示文摘Prowse AH Manek S Varma H 2006Int J Canc-er2006,119,3:1
11Estuarine mud flocculation properties determined using an annular mini- flume and the LabSFLOC system 显示文摘Manning A J Friend P L Prowse N 2007Continental Shelf Research2007,27,8:1
12Specific association of human telomerase activity with immortal cells and cancer显示文摘Kim NW Piatyszek MA Prowse KR 1994Science1994,266,:1
13Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell prolifereation with extensive axonal outgrowth following transplantation显示文摘Ostenfeld T Caldwell MA Prowse KR 2000Exp Neuol2000,164,:1
14Specific associcaion of human telomerase activity with mmortal cells and cancer显示文摘 Pialyszek MA Prowse KR 1994Science1994,266,5193:1
15Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal outgrowth following transplantion显示文摘Ostenfeld T Caldwell MA Prowse KR 2000Exp Neurol2000,164,:1
16Specific association of human telomerase activity with immortal cells and cancer显示文摘Kim NW Piatyszek MA Prowse KR 1994Science1994,266,5193:1
17Specific association of human telomerase activity with immortal cells and cancer 显示文摘 Piatyszek MA Prowse KR 1994Science1994,266,:1
18Application of a Grouped Response Unit Hydrological Model to a Northern Wetland Region 显示文摘Pietroniro A Prowse T Hamlin L 1996Mydrological Processes1996,,10:1
19Specific association of human telomerase activity with immortal cells and cancer显示文摘Kim NW Piatyszek MA Prowse KR 1994Science1994,266,5193:1
20Specific association of human telomerase activity with immortal cells and cancer 显示文摘Kim NM Piatyszek MA Prowse KR 1994Sciense1994,266,5194:1
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