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| 1 | Growth-Regulating Factors (GRFs): A Small Transcription Factor Family with Important Functions in Plant Biology显示文摘调整生长的因素(GRF ) 是原来在茎和叶开发为他们的角色被识别的植物特定的抄写因素,但是最近的研究加亮他们为在不利环境条件下面包括生长过程的花和种子形成,根发展,和协作的另外的中央发展过程同样重要。几 GRF 的表达式被 microRNA miR396 控制,并且 GRF-miRNA396 规章的模块看起来对几这些进程中央。另外, GRF 和 miR396 在上游的抄写因素被发现了,并且下游地逐渐地指向 GRF 的基因被解开。这里,我们考察 GRF 执行的生物功能的当前的知识并且调查可得到的分子的数据说明他们怎么在细胞的水平施加角色。 | Mohammad Amin Omidbakhshfard Sebastian Proost Ushio Fujikura Bernd Mueller-Roeber | 2015 | Molecular Plant2015，8，7： | 51 |
| 2 | The unique structural and functional features of CXCL12显示文摘The CXC chemokine CXCL12 is an important factor in physiological and pathological processes, includingembryogenesis, hematopoiesis, angiogenesis and inflammation, because it activates and/or induces migration ofhematopoietic progenitor and stem cells, endothelial cells and most leukocytes. Therefore, CXCL12 activity istightly regulated at multiple levels. CXCL12 has the unique property of existing in six splice variants in humans,each having a specific tissue distribution and in vivo activity. Controlled splice variant transcription and mRNAstability determine the CXCL12 expression profile. CXCL12 fulfills its functions in homeostatic and pathologicalconditions by interacting with its receptors CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3(ACKR3) and by binding to glycosaminoglycans (GAGs) in tissues and on the endothelium to allow a properpresentation to passing leukocytes. Homodimerizaton and heterodimerization of CXCL12 and its receptors can altertheir signaling activity, as exemplified by the synergy between CXCL12 and other chemokines in leukocyte migrationassays. Receptor binding may also initiate CXCL12 internalization and its subsequent removal from theenvironment. Furthermore, CXCL12 activity is regulated by posttranslational modifications. Proteolytic removal ofNH2- or COOH-terminal amino acids, citrullination of arginine residues by peptidyl arginine deiminases or nitrationof tyrosine residues reduce CXCL12 activity. This review summarizes the interactions of CXCL12 with the cellularenvironment and discusses the different levels of CXCL12 activity regulation. | Rik Janssens Sofie Struyf Paul Proost | 2018 | Cellular & Molecular Immunology2018，15，4： | 28 |
| 3 | Neutrophil chemoattractant receptors in health and disease: double-edged swords显示文摘Neutrophils are frontline cells of the innate immune system.These effector leukocytes are equipped with intriguing antimicrobial machinery and consequently display high cytotoxic potential.Accurate neutrophil recruitment is essential to combat microbes and to restore homeostasis,for inflammation modulation and resolution,wound healing and tissue repair.After fulfilling the appropriate effector functions,however,dampening neutrophil activation and infiltration is crucial to prevent damage to the host.In humans,chemoattractant molecules can be categorized into four biochemical families,i.e.,chemotactic lipids,formyl peptides,complement anaphylatoxins and chemokines.They are critically involved in the tight regulation of neutrophil bone marrow storage and egress and in spatial and temporal neutrophil trafficking between organs.Chemoattractants function by activating dedicated heptahelical G protein-coupled receptors(GPCRs).In addition,emerging evidence suggests an important role for atypical chemoattractant receptors(ACKRs)that do not couple to G proteins in fine-tuning neutrophil migratory and functional responses.The expression levels of chemoattractant receptors are dependent on the level of neutrophil maturation and state of activation,with a pivotal modulatory role for the(inflammatory)environment.Here,we provide an overview of chemoattractant receptors expressed by neutrophils in health and disease.Depending on the(patho)physiological context,specific chemoattractant receptors may be up-or downregulated on distinct neutrophil subsets with beneficial or detrimental consequences,thus opening new windows for the identification of disease biomarkers and potential drug targets. | Mieke Metzemaekers Mieke Gouwy Paul Proost | 2020 | Cellular & Molecular Immunology2020，17，5： | 8 |
| 4 | The chemokines CXCL8 and CXCL12:molecular and functional properties,role in disease and efforts towards pharmacological intervention显示文摘Chemokines are an indispensable component of our immune system through the regulation of directional migration and activation of leukocytes.CxCL8 is the most potent human neutrophil-attracting chemokine and plays crucial roles in the response to infection and tissue injury.CXCL8 activity inherently depends on interaction with the human CXC chemokine receptors CXCR1 and CXCR2,the atypical chemokine receptor ACKR1,and glycosaminoglycans.Furthermore,(hetero)dimerization and tight regulation of transcription and translation,as well as post-translational modifications further fine-tune the spatial and temporal activity of CXCL8 in the context of inflammatory diseases and cancer.The CxCL8 interaction with receptors and glycosaminoglycans is therefore a promising target for therapy,as illustrated by multiple ongoing clinical trials.CXCL8-mediated neutrophil mobilization to blood is directly opposed by CXCL12,which retains leukocytes in bone marrow.CXCL12 is primarily a homeostatic chemokine that induces migration and activation of hematopoietic progenitor cells,endothelial cells,and several leukocytes through interaction with CXCR4,ACKR1,and ACKR3.Thereby,it is an essential player in the regulation of embryogenesis,hematopoiesis,and angiogenesis.However,CXCL12 can also exert inflammatory functions,as illustrated by its pivotal role in a growing list of pathologies and its synergy with CXCL8 and other chemokines to induce leukocyte chemotaxis.Here,we review the plethora of information on the CXCL8 structure,interaction with receptors and glycosaminoglycans,different levels of activity regulation,role in homeostasis and disease,and therapeutic prospects.Finally,we discuss recent research on CXCL12 biochemistry and biology and its role in pathology and pharmacology. | Seppe Cambier Mieke Gouwy Paul Proost | 2023 | Cellular & Molecular Immunology2023，20，3： | 4 |
| 5 | Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact显示文摘 | Van den Steen PE Proost P Wuyts A | 2000 | Blood2000，96，： | 1 |
| 6 | Congestion and tax competition on a parallel network 显示文摘 | Borger B D Proost S Dender K V | 2005 | European Economic Review2005，49，8： | 1 |
| 7 | Microbial Toll-like receptor ligands differentially regulate CXCL10/IP-10 expression in fibroblasts and mononuclvar lvukocytes in synergy with IFN-γ and provide a mechanism for enhanced synovial chemokine levels in septic arthritis显示文摘 | Proost P Vynckier AK Mahieu F | 2003 | Eur J Immunol2003，33，11： | 1 |
| 8 | Recovery of precious metals from electronic scrap by hydrometalluraicel processing routes显示文摘 | Qulnet P Proost J Lierde A V | 2005 | Minerals and Metallurgical Proces sing2005，22，1： | 1 |
| 9 | Congestion and tax competition in a parallel network显示文摘 | Borger B D Proost S Dender K V | 2005 | European Economic Review2005，49，： | 1 |
| 10 | A response surface model approach for continuous measures of hypnotic and analgesic effect during sevofluranremifentanil interaction: quantifying the pharma- codynamic shift evoked by stimulation显示文摘 | Heyse B Proost J H Hannivoort L N | 2014 | Anesthesiology2014，120，6： | 1 |
| 11 | Congestion and Tax Competition in a Parallel Network显示文摘 | Borger B D Proost S Dender K V | 2005 | European Economic Review2005，，49： | 1 |
| 12 | Monocyte chemoatic protein-1 (MCP-1),-2,and-3 are chemotactic for human T lymphocytes 显示文摘 | Proost P Murphy WJ | 1995 | J Clin Invest1995，95，3： | 1 |
| 13 | Neutrophil gelatinase B protentiates interleukin-8 tenfold by aminoterminal processing,whereas it degrades CTAP-Ⅲ,PF-4,and GRO-alpha and leaves RANTES and MCP-2 intact显示文摘 | Van den Steen PE Proost P Wuyts A | 2000 | Blood2000，96，8： | 1 |
| 14 | Investment and the use of tax and toll revenues in the transport sector 显示文摘 | Depalma A Lindsey R Proost S | 2007 | Research in Trans- portation Economics2007，19，4： | 1 |
| 15 | A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancer 显示文摘 | Calbo J van-Montfort E Proost N | 2011 | Cancer Cell2011，19，2： | 1 |
| 16 | Processing by CD26/dipep- tidyl-peptidase IV reduces the chemotactic and anti-HIV-I ac- tivity of stromal-cell-derived factor-lalpha 显示文摘 | Proost P Struyf S Schols D | 1998 | FEBS Lett1998，432，12： | 1 |
| 17 | Neutrophil gelatinase B potentiates intedeukin-8 tenfold by aminoterminal processing,whereas it degrades CTAP-IⅢ, pF-d, and GRO-alpha and leaves RANTES and MCP-2 intact显示文摘 | Vanden Steen PE Proost P Wuyts A | 2000 | Blood2000，96，8： | 1 |
| 18 | The application of p-version finite element methods to fracture-dominated problems encountered in engineering practice 显示文摘 | Proost Domasky S A Brooks C L Honeycutt K T | 2003 | Computers & Mathematics with Applications2003，46，1： | 1 |
| 19 | Synergy in cytokine and che- mokine networks amplifies the inflammatory response 显示文摘 | Gouwy M Struyf S Proost P | 2005 | Cyto- kine Growth Factor Rev2005，16，6： | 1 |
| 20 | Recovery of precious metals from electronic scrap by hydrometallurgical processing routes显示文摘 | Quinet P Proost J Lierde A V | 2005 | Minerals and Metallurgical Processing2005，22，1： | 1 |
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