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| 1 | Angiogenin and tRNA fragments in Parkinson’s disease and neurodegeneration显示文摘In this review,we summarise the evidence for a role of the ribonuclease angiogenin in the pathophysiology of neurodegenerative disorders,with a specific focus on Parkinson’s disease(PD).Angiogenin is a stress-induced,secreted ribonuclease with both nuclear and cytosolic activities.Loss-of-function mutations in the angiogenin gene(ANG)have been initially discovered in familial cases of amyotrophic lateral sclerosis(ALS),however,variants in ANG have subsequently been identified in PD and Alzheimer’s disease.Delivery of angiogenin protein reduces neurodegeneration and delays disease progression in in vitro and in vivo models of ALS and in vitro models of PD.In the nucleus,angiogenin promotes ribosomal RNA transcription.Under stress conditions,angiogenin also translocates to the cytosol where it cleaves non-coding RNA into RNA fragments,in particular transfer RNAs(tRNAs).Stress-induced tRNA fragments have been proposed to have multiple cellular functions,including inhibition of ribosome biogenesis,inhibition of protein translation and inhibition of apoptosis.We will discuss recent evidence of tRNA fragment accumulation in PD,as well as their potential neuroprotective activities. | Jochen H M Prehn Elisabeth Jirstrom | 2020 | Acta Pharmacologica Sinica2020，41，4： | 2 |
| 2 | Multiple-bridged bis-tetrathiafulvalenes:new synthetic protocols and spectroelectrochemicalinvestigations显示文摘 | Spanggard H Prehn J Becher J | 2000 | J Am Chem Soc2000，122，： | 1 |
| 3 | An orthotopic model of murine osteosarcoma with clonally related variants differing in pulmonary metastatic potential 显示文摘 | Khanna C Prehn J Yeung C | 2000 | Clin Exp Metastasis2000，18，3： | 1 |
| 4 | Sliding wear performance of polymer composites under abrasive and water lubricated conditions for pump applications显示文摘 | Prehn R Haupert F Friedrich K | 2005 | Wear2005，259，16： | 1 |
| 5 | Successful skin homografts after the administration of high dosage X radiation and homologous bone marrow显示文摘 | Main J M Prehn R T | 1955 | J Natl Cancer Inst1955，15，4： | 1 |
| 6 | Apoptosis signaling proteins asprognostic biomarkers in colorectal cancer: a review 显示文摘 | HECTOR S PREHN J H | 2009 | Biochim Biophys Acta2009，1795，2： | 1 |
| 7 | The beta2-adrenoceptor against clenbuterol moduiates bcl-2,bcl-xl and bax protein expression follow- ing transient forebrain ischemia 显示文摘 | Zhu Y Prehn J Culmsee C | 1999 | Neuroscience1999，90，4： | 1 |
| 8 | p53 expression induces apoptosis in hippocampal pyramidal neuron cultures显示文摘 | Jordan J Galindo MF Prehn JH | 1997 | J Neurosci1997，17，4： | 1 |
| 9 | Regulation of neuronal Bcl- 2 protein expression and calcuim homeostasis by transforming growth factor type beta confers wide- ranging protection on rat hippocampal neurons显示文摘 | Bindokas VP Marcuccilli CJ | 1994 | Proc Natl Acad Sci USA1994，91，12： | 1 |
| 10 | S IOOB in brain damage and neurodegeneration 显示文摘 | Rothermundt M Peters M Prehn JH | 2003 | Microsc Res Tech2003，60，6： | 1 |
| 11 | The DAP kinase family of pro-apoptotic proteins:novel players in the apoptotic game显示文摘 | Kogel D Prehn J H M Scheidtmann K H | 2001 | Bio Essays2001，23，： | 1 |
| 12 | Potential role for TL1A, the new TNF family member and potent costimulator of IFN gamma, in mucosal inflammation 显示文摘 | Prehn JL Mehdizadeh S Landers CJ | 2004 | Clin Immunol2004，112，1： | 1 |
| 13 | Activation of ATP-sensitive potassium channels decreases neuronal injury caused by chemical hypoxia显示文摘 | Wind T Prehn JH Peruche B | 1997 | Brain Res1997，751，2： | 1 |
| 14 | Cytokine gene expression in rejecting and tolerant rat lung allograft models:analysis by RTPCR显示文摘 | Zuo XJ Matsumura Y Prehn J | 1995 | Transplant Immunol1995，3，1： | 1 |
| 15 | Neuronal apoptosis:BH3-only proteins the real killers? 显示文摘 | WARD MW KOGEL D PREHN JH | 2004 | J Bioenerg Biomembr2004，36，4： | 1 |
| 16 | S100B in brain damage and neurodegeneration 显示文摘 | Rothermundt M Peters M Prehn JH | 2003 | Microsc Res Tech2003，60，6： | 1 |
| 17 | TLIA synergizes with IL-12 and IL-18 to enhance IFN-gamma production in human T cells and NK cells 显示文摘 | Papadakis KA Prehn JL Landers C | 2004 | J Immunol2004，172，11： | 1 |
| 18 | S100B in brain damageand neurodegeneration 显示文摘 | Rothermundt M Peters M Prehn JH | 2003 | Microsc Res Tech2003，60，6： | 1 |
| 19 | Toward endografting of the ascending aorta: insight into dynamics using dynamic cine-CTA 显示文摘 | van Prehn J Vincken KL Muhs BE | 2007 | J Endovasc Ther2007，14，： | 1 |
| 20 | Regulation of neuronal Bcl 2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide ranging protection on rat hippocampal neurons 显示文摘 | Prehn J H Bindokas V P Marcuccilli C J | 1994 | Proc Natl Acad Sci U SA1994，91，12： | 1 |
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