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| 1 | Managing osteoporosis in ulcerative colitis: Something new?显示文摘The authors revise the latest evidence in the literature regarding managing of osteoporosis in ulcerative colitis(UC), paying particular attention to the latest tendency of the research concerning the management of bone damage in the patient affected by UC. It is wise to assess vitamin D status in ulcerative colitis patients to recognize who is predisposed to low levels of vitamin D, whose deficiency has to be treated with oral or parenteral vitamin D supplementation. An adequate dietary calcium intake or supplementation and physical activity, if possible, should be guaranteed. Osteoporotic risk factors, such as smoking and excessive alcohol intake, must be avoided. Steroid has to be prescribed at the lowest possible dosage and for the shortest possible time. Moreover, conditions favoring falling have to been minimized, like carpets, low illumination, sedatives assumption, vitamin D deficiency. It is advisable to assess the fracture risk in all UC patient by the fracture assessment risk tool(FRAX tool), that calculates the ten years risk of fracture for the population aged from 40 to 90 years in many countries of the world. A high risk value could indicate the necessity of treatment, whereas a low risk value suggests a followup only. An intermediate risk supports the decision to prescribe bone mineral density(BMD) assessment and a subsequent patient revaluation for treatment. Dual energy X-ray absorptiometry bone densitometry can be used not only for BMD measurement, but also to collect data about bone quality by the means of trabecular bone score and hip structural analysis assessment. These two indices could represent a method of interesting perspectives in evaluating bone status in patients affected by diseases like UC, which may present an impairment of bone quality as well as of bone quantity. In literature there is no strong evidence for instituting pharmacological therapy of bone impairment in UC patients for clinical indications other than those that are also applied to the patients with osteoporosis. Therefore, a reasonable advice is to consider pharmacological treatment for osteoporosis in those UC patients who already present fragility fractures, which bring a high risk of subsequent fractures. Therapy has also to be considered in patients with a high risk of fracture even if it did not yet happen, and particularly when they had long periods of corticosteroid therapy or cumulative high dosages. In patients without fragility fractures or steroid treatment, a medical decision about treatment could be guided by the FRAX tool to determine the intervention threshold. Among drugs for osteoporosis treatment, the bisphosphonates are the most studied ones, with the best and longest evidence of efficacy and safety. Despite this, several questions are still open, such as the duration of treatment, the necessity to discontinue it, the indication of therapy in young patients, particularly in those without previous fractures. Further, it has to be mentioned that a longterm bisphosphonates use in primary osteoporosis has been associated with an increased incidence of dramatic side-effects, even if uncommon, like osteonecrosis of the jaw and atypical sub-trochanteric anddiaphyseal femoral fractures.UC is a long-lasting disease and the majority of patients is relatively young.In this scenario primary prevention of fragility fracture is the best cost-effective strategy.Vitamin D supplementation,adequate calcium intake,suitable physical activity(when possible),removing of risk factors for osteoporosis like smoking,and avoiding falling are the best medical acts. | Luca Petruccio Piodi Alessandro Poloni Fabio Massimo Ulivieri | 2014 | World Journal of Gastroenterology2014，20，39： | 7 |
| 2 | An Integrated Approach for Optimal Design of Micro Gas Turbine Combustors显示文摘The present work presents an approach for the optimized design of small gas turbine combustors, that integrates a0-D code, CFD analyses and an advanced game theory multi-objective optimization algorithm. The output of the0-D code is a baseline design of the combustor, given the required fuel characteristics, the basic geometry (tubularor annular) and the combustion concept (i.e. lean premixed primary zone or diffusive processes). For the optimizationof the baseline design a simplified parametric CAD/mesher model is then defined and submitted to a CFDcode. Free parameters of the optimization process are position and size of the liner hole arrays, their total area andthe shape of the exit duct, while different objectives are the minimization of NOx emissions, pressure losses andcombustor exit Pattern Factor. A 3D simulation of the optimized geometry completes the design procedure. As afirst demonstrative example, the integrated design process was applied to a tubular combustion chamber with alean premixed primary zone for a recuperative methane-fuelled small gas turbine of the 100 kW class. | Luca Fuligno Diego Micheli Carlo Poloni | 2009 | Journal of Thermal Science2009，18，2： | 2 |
| 3 | Microstructural evolution of modified 9Cr-1Mo steel显示文摘 | Wendell B. Jones C. R. Hills D. H. Polonis | 1991 | Metallurgical Transactions A1991，，5： | 1 |
| 4 | Engraftment capacity of mesenchymal cells following hematopoietie stem cell transplantation in patients receiving reduced-intensity conditioning regimen 显示文摘 | Poloni A Leoni P Buscemi L | 2006 | Leukemia2006，20，2： | 1 |
| 5 | Detection of Dengue virus in saliva and urine by real time RT-PCR显示文摘 | Poloni T R Oliveira A S Alfonso H L | 2010 | Virol J2010，7，： | 1 |
| 6 | Magnetic resonance spectroscopy in the evaluation of treatment efficacy in unipolar major de- pressive disorder: a review of the literature 显示文摘 | Caverzasi E Pichiecchio A Poloni GU | 2012 | Funct Neurel2012，27，1： | 1 |
| 7 | Optimization of wind turbine positioning in large wind farms by means of a ge- netic algorithm 显示文摘 | Mosetti G Poloni C Diviacco B | 1994 | Wind Engineering and Industrial Aer- odynamics1994，51，1： | 1 |
| 8 | The endless welding rolling process显示文摘 | Lestani M Poloni A | 1999 | MPT International1999，22，1： | 1 |
| 9 | Epitope mapping of the monoclonal antibody MM12.10 to external MDR1 P-glycoprotein domain by synthetic peptide scanning and phage display technologies显示文摘 | Romagnoli G Poloni F Flego M | | 0，，： | 1 |
| 10 | Hypoxia-inducible factor-1α is a positive factor in solid tumor growth显示文摘 | Ryan HE Poloni M McNuhy W | 2000 | Cancer Res2000，60，15： | 1 |
| 11 | Hypoxia -inducible factor-1 alpha is a positive factor in solid tumor growth显示文摘 | Ryan HE Poloni M McNulty W | 2000 | Cancer Res2000，60，15： | 1 |
| 12 | Hypoxia-inducible factor-1α is a positive factor in solid tumor growth 显示文摘 | Ryan HE Poloni M McNulty W | 2000 | Cancer Res2000，60，15： | 1 |
| 13 | Validation of a HPLC method for simultaneous determination of main organic acids in fruits andjuices显示文摘 | Rodrigo Scherer Ana Cecilia Poloni Rybka Cristiano Augusto Ballus | 2012 | Food Chemistry2012，135，1： | 1 |
| 14 | Hypoxia-inducible factor-1 alpha is a positive factor in solid tumor growth显示文摘 | Ryan HE Poloni M McNuhy W | 2000 | Cancer Res2000，60，15： | 1 |
| 15 | Hypoxia-inducible factor-l alpha is a positive factor in solid tumor growth显示文摘 | Ryan HE Poloni M McNulty W | 2000 | Cancer Res2000，60，15： | 1 |
| 16 | Effect of amifostine on mucositis during autologous PBSCT transplantation显示文摘 | Olivieri A Poloni A Capelli D | 1998 | Blood1998，92，101： | 1 |
| 17 | Flt 3 ligand,MGDF,Epo and G-CSF enhance ex vivo expansion of hematopoietic cell compartments in the presence of SCF,IL-3 and IL-6显示文摘 | Kobari L Giarratana MC Poloni A | 1998 | Bone Marrow Transplant1998，21，8： | 1 |
| 18 | Hypoxia-inducible factor-1 alpha is a positive factor in solid tumor growth显示文摘 | Ryan HE Poloni M McNulty W | 2000 | Cancer Res2000，60，15： | 1 |
| 19 | Hypoxia-inducible factor-lalpha is a positive factor in solid tumor growth 显示文摘 | Ryan HE Poloni M McNulty W | 2000 | Cancer Res2000，60，15： | 1 |
| 20 | Serum IgA-mediated neutralization of HIV type 1显示文摘 | VanCott TC Polonis VR | 1994 | J Immunol1994，152，9： | 1 |
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