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| 1 | Zinc in plants:Integrating homeostasis and biofortification显示文摘Zinc plays many essential roles in life.As a strong Lewis acid that lacks redox activity under environ-mental and cellular conditions,the Zn2+cation is central in determining protein structure and catalytic function of nearly 10%of most eukaryotic proteomes.While specific functions of zinc have been elucidated at a molecular level in a number of plant proteins,wider issues abound with respect to the acquisition and distribution of zinc by plants.An important challenge is to understand how plants balance between Zn supply in soil and their own nutritional requirement for zinc,particularly where edaphic factors lead to a lack of bioavailable zinc or,conversely,an excess of zinc that bears a major risk of phyto-toxicity.Plants are the ultimate source of zinc in the human diet,and human Zn deficiency accounts for over 400000 deaths annually.Here,we review the current understanding of zinc homeostasis in plants from the molecular and physiological perspectives.We provide an overview of approaches pursued so far in Zn biofortification of crops.Finally,we outline a'push-pull'model of zinc nutrition in plants as a simplifying concept.In summary,this review discusses avenues that can potentially deliver wider bene-fits for both plant and human Zn nutrition. | Camilla Stanton Dale Sanders Ute Krämer Dorina Podar | 2022 | Molecular Plant2022，15，1： | 3 |
| 2 | Immunomodulatory analogues of thalidomide inhibit growth of Ha Sultan cells and angiogenesis in vivo显示文摘 | Lentzsch S LeBlanc R Podar K | 2008 | Leukemia2008，17，1： | 1 |
| 3 | The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment显示文摘 | Lin B Podar K Gupta D | 2002 | Cancer Res2002，62，17： | 1 |
| 4 | Mortality in patients with childhood-onset type 1 diabetes in Finland,Estonia,and Lithuania:follow-up of nationwide cohorts显示文摘 | Podar T Solntsev A Reunanen A | 2000 | Diabetes Care2000，23，3： | 1 |
| 5 | Bone marrow micro- environment and the identification of new targets for myeloma therapy显示文摘 | Podar K Chanhan D Anderson KC | 2009 | Leukemia2009，23，1： | 1 |
| 6 | Essential role of caveolae in interleukin-6 and insulin-like growth factor I-triggered Akt-1- mediated survival of multiple myeloma cells显示文摘 | Podar K Tai YT Cole CE | 2003 | J Biol Chem2003，278，8： | 1 |
| 7 | The stereochemical course of group Ⅱ intron self-splicing显示文摘 | Padgett R A Podar M Boulanger S C | 1994 | Science1994，266，5191： | 1 |
| 8 | Multiplemyeloma显示文摘 | Raab MS Podar K Breitkreutz I | 2009 | Lancet2009，374，9686： | 1 |
| 9 | Multiple myeloma显示文摘 | Raab MS Podar K Breitkreutz I | 2009 | Lancet2009，374，9686： | 1 |
| 10 | Multiple myeloma显示文摘 | Raab MS Podar K Breitkreutz I | 2009 | Laneet2009，374，9686： | 1 |
| 11 | Novel therapies targeting the myeloma cell and Its bone marrow mieroenvironment显示文摘 | Hideshima T Chauhan D Podar K | 2001 | Semin Oncol2001，28，6： | 1 |
| 12 | CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma celia显示文摘 | Tai YT Podar K Gupta D | 2002 | Blood2002，99，4： | 1 |
| 13 | Evolution of a microbial nitrilase gene family: a comparative and environmental genomics study显示文摘 | PODAR M | 2005 | BMC Evol Biol2005，5，8： | 1 |
| 14 | The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ ZK222584 inhibits growth and migration of multiple mye loma cells in the bone marrow microenvironment 显示文摘 | Lin B Podar K Gupta D | 2002 | Cancer Res2002，62，17： | 1 |
| 15 | Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents,in multi- ple myeloma显示文摘 | Hideshima T Chauhan D Hayashi T Podar K Akiyama M Mitsiades C | 2003 | Cancer Res2003，63，： | 1 |
| 16 | The vascular endothelialgrowth factor receptor tyrosine kinase inhibitor PTK787 / ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment显示文摘 | LIN B PODAR K GUPTA D | 2002 | Cancer Res2002，62，17： | 1 |
| 17 | Novel therapies targeting the myeloma cell and its bone marrow microenvironment 显示文摘 | Hideshima T Chauhan D Podar K | 2001 | Semin Oncol2001，28，6： | 1 |
| 18 | Vascular endothelial growth factor triggers signaling cascsdes mediating multiple myeloma cell growth and migration 显示文摘 | Podar K Tai YT Dacies FE et aL | 2001 | Blood2001，98，： | 1 |
| 19 | Cytokines and signal transduction显示文摘 | Hideshima T Podar K Chauhan D | 2005 | Best Pract Res Clin Haematol2005，18，： | 1 |
| 20 | A pivotal role for Mcl-1 in Bortezomib-induced apoptosis显示文摘 | Podar K Gouill SL Zhang J | 2008 | Oncogene2008，27，6： | 1 |
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