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	题名	作者	年代	出处	被引量
1	Aberrant cytological localization of p16 and CDK4 in colorectal epithelia in the normal adenoma carcinoma sequence显示文摘AIM: To study the correlation between the patterns of subcellular expression of p16 and CDK4 in colorectal epithelia in the normal-adenoma-carcinoma sequence. METHODS: Paraffin sections of 43 cases of normal colorectal epithelia and corresponding adenomas as well as carcinomas were analysed immunocytochemically for subcellular expression of p16 and CDK4 proteins. RESULTS: Most carcinomas showed more cytoplasmic overexpression for p16 and CDK4 than the adenomas from which they arised or the adjacent normal mucosa. Most normal or non-neoplastic epithelia showed more p16 and CDK4 expression in the nucleus than their adjacent adenomas and carcinomas. There was a significant difference between the subcellular expression pattern of p16 and CDK4 in normal-adenoma-carcinoma sequence epithelia (P < 0.001). Neither p16 nor CDK4 subcellular patterns correlated with histological grade or Dukes’ stage. CONCLUSION: Interaction of expression of p16 and CDK4 plays an important role in the Rb/p16 pathway. Overexpression of p16 and CDK4 in the cytoplasm, as well as loss expression of p16 in the nucleus might be important in the evolution of colorectal carcinoma from adenoma and, of adenoma from normal epithelia.	PO Zhao Xin Mao Ian C Talbot	2006	World Journal of Gastroenterology2006，12，39：	5
2	Induction of antibodies against GD3 ganglioside in melanoma patients by vaccination with GD3-1actone-KLH conjugate plus immunological adjuvant QS-21 显示文摘	Ragupathi G Meyers M Adluri S Howard L Musselli C Livingston PO	2000	Int J Cancer2000，85，5：	1
3	Clinical measures of disease severity and outcome in psoriasis:a critical appraisal of their quality显示文摘	ASHCROFT D M WAN PO A L WILLIAMS H C	1999	Br J Dermatol1999，141，2：	1
4	Autophagosome-associated variant isoforms of cytosolic enzymes显示文摘	Fengsrud M Raiborg C Berg TO Strmhaug PE Ueno T Erichsen ES Seglen PO	2000	Biochem J2000，352，3：	1
5	A novel four step search algorithm for fast block motion estimation显示文摘	Po L M Ma W C	1996	IEEE Trans Circuits Syst Video Technol1996，6，3：	1
6	Decolorization of textile wastewater by photo-Fenton oxidation technology显示文摘	Kang S F Liao C H Po S T	2000	Chemosphere2000，41，：	1
7	Genetic engineering of fibrous: spider dragline silk and collagen显示文摘	Wong Po Foo C Kaplan DL	2002	AdvDrug Deliv Rev2002，54，8：	1
8	Frequency of complications after uvulopalato pharyngoplasty 显示文摘	Carenfelt C Haraldsson PO	1993	Lancet1993，341，8842：	1
9	Study of ocular surface involvement in diabetic patients显示文摘	Creuzot-Garcher C Lafontaine PO Gualino O		0，，：	1
10	Arginase inhibition me diates cardioprotection during ischaemia-reperfusion 显示文摘	Jung C Gonon AT Sjoquist PO etal	2010	Card- iovasc Res2010，85，：	1
11	Respiratory disease associated with solid biomass fuel exposure in rural women and children:systematic re- view and meta-analysis显示文摘	Po JT Fitzgerald JM Carlsten C	2011	Thorax2011，66，：	1
12	A novel four-step algorithm for fast block motion estimation显示文摘	Po L M Ma W C	1996	IEEE Transactions on Circuits and Systems for Video Technology1996，6，：	1
13	Statin effects beyond lipid lowering are they clinically relevant 显示文摘	Bonetti PO Lerman LO Napoli C	2003	Eur Heart J2003，24，3：	1
14	Consistent antibody response against ganglio-side GD2 induced in patients with melanoma by a GD2 lactonekeyhole limpet hemoeyanin conjugate vaccine plus immunological adjuvant QS-21 显示文摘	Ragupathi G Livingston PO Hood C Gathuru J Krown SE Chapman PB	2003	Clin Cancer Res2003，9，14：	1
15	Statin effects beyond lipid lowering: are they clinically relevant显示文摘	Bonetti PO Lerman LO Napoli C	2003	Eur Heart J2003，24，：	1
16	Imerphase precipltadon of nanometer-sized carbides in a titanium molybdenum bearing low carbon steel显示文摘	Hung W Y Po Y C Ching Y H e* al	2011	Acta Materialia2011，59，：	1
17	The gap junction protein Cx43 is involved in the bone-targeted metastatic behaviour of human prostate cancer cells显示文摘	Lamiche C Clarhaut J Strale PO	2012	Clin Exp Metastasis2012，29，2：	1
18	Transcriptional coactivation of nuclear factor - kappa B - dependent geneexpression by p300 is regulated by poly (ADP) - ribose polymerase - 1 显示文摘	Hassa PO Buerki C Lombardi C	2003	J Biol Chem2003，278，45：	1
19	Individual psychosocial support for breast cancer patients: a randomized study of nurse versus psychologist interventions and standard care显示文摘	Arving C Skoden PO Bergh J	2007	Cancer Nuts2007，30，3：	1
20	A novel four-step algorithm for last block motion estimation显示文摘	Po L M Ma W C	1996	IEEE Transactions on Circuits and Systems for Video Technology1996，6，3：	1

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