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| 1 | Ultrasound-triggered noninvasive regulation of blood glucose levels using microgels integrated with insulin nanocapsules显示文摘Diabetes is a serious public health problem affecting 422 million people worldwide. Traditional diabetes management often requires multiple daily insulin injections, associated with pain and inadequate glycemia control. Herein, we have developed an ultrasound-triggered insulin delivery system capable of pulsatile insulin release that can provide both long-term sustained and fast on-demand responses. In this system, insulin-loaded poly(lactic-co-glycolic acid) (PLGA) nanocapsules are encapsulated within chitosan microgels. The encapsulated insulin in nanocapsules can passively diffuse from the nanoparticle but remain restricted within the microgel. Upon ultrasound treatment, the stored insulin in microgels can be rapidly released to regulate blood glucose levels. In a chemically-induced type 1 diabetic mouse model, we demonstrated that this system, when activated by 30 s ultrasound administration, could effectively achieve glycemic control for up to one week in a noninvasive, localized, and pulsatile manner. | Jin Di Jicheng Yu Qun Wang Shanshan Yao Yanqi Ye Matthew Pless Yong Zhu Yun Jing Zhen Gu | 2017 | Nano Research2017，10，4： | 6 |
| 2 | 腹腔镜结合腹腔镜超声在肝门部胆管癌治疗中的作用显示文摘背景目前影像学已高度发展,但肝门部胆管癌的手术适应症仍是困扰外科医师的难题,多数患者发现时已为晚期,丧失了手术时机。而不必要的腹腔镜检查增加的手术并发症发生率和死亡率更是令肝门部胆管癌极差的预后雪上加霜。目的评价腹腔镜结合腹腔镜超声(LAP/LUS)检查在肝门部胆管癌可切除率评估中的作用。 | K. Srensen C. H. Nielsen M. Mortensen T. Pless | 2009 | 肝胆外科杂志2009，，5： | 2 |
| 3 | Cyclic codes and quadratic codes over Z4 显示文摘 | Pless V S Qian Z | 1996 | IEEE Trans Inform Theory1996，42，： | 1 |
| 4 | The effect of wrist guard use on upper-extremity injuries in snowboarders显示文摘 | Hagel B Pless IB Goulet C | 2005 | Am J Epidemiol2005，2，： | 1 |
| 5 | Linear β-1,3-glucans are elicitors of defense responses in tobacco显示文摘 | KLARZYNASKI O PLESSE B JOUBERT J M | 2000 | Plant Physiology2000，124，： | 1 |
| 6 | Identifying childfunctioning from an ICF-CY perspective: Everyday life sit-uations explored in measures of participation 显示文摘 | Adolfsson M Malmqvist J Pless M | 2011 | DisabilRehabil2011，33，1314： | 1 |
| 7 | Bioartificial liver:current status 显示文摘 | Pless G Sauer IM | 2005 | Transplant Proc2005，37，9： | 1 |
| 8 | Responsible Leadership in a Stakeholder Society:A Relational Perspective 显示文摘 | Maak T Pless N M | 2006 | Journal of Business Eth- ics2006，66，1： | 1 |
| 9 | The clinical value of-D-Phe^1-Tyr^3-octreotide (^90Y-DOTATOC) in the treatment of neuroendocrine tumours:A clinical phase Ⅱ study显示文摘 | WALDHERR C PLESS M MAECKE HR | 2001 | Ann Oncol2001，12，7： | 1 |
| 10 | Evaluation of the quality of an injury surveillance system 显示文摘 | Macarthur C Pless IB | 1999 | Am J Epidemiol1999，149，6： | 1 |
| 11 | Targeted radiotherapy for small cell lung cancer using 90Y-DOTATOC, an Yttriumlabelled somatostatin analogue: a pilot trial显示文摘 | Pless M Waldherr C Maecke H | 2004 | Lung Cancer2004，45，3： | 1 |
| 12 | Linear β-1,3-glucanase are elicitors of defense responses in tobacco显示文摘 | Klarzynaski O Plesse B Joubert J M | 2000 | Plant Physiol2000，124，： | 1 |
| 13 | Fault tolerant k-center problem显示文摘 | KHULLER S PLESS R SUSSMANN Y J | | 0，，： | 1 |
| 14 | Tumor treating fields : concept, evidence and future显示文摘 | Pless M Weinberg U | 2011 | Expert Opin Investig Drugs2011，20，8： | 1 |
| 15 | Cyclic self-dual Z4-codes显示文摘 | PLESS V SOLE P QIAN Z | 1997 | Finite Fields and Their Applications1997，3，： | 1 |
| 16 | A phase I/II trial of combina-tion with pemetrexed Tumor Treating Fields therapy in for advanced non-small cell lung cancer 显示文摘 | Pless M Droege C von Moos R | 2013 | Lung Cancer2013，81，3： | 1 |
| 17 | Latent phenoloxidase activity and N-terminal amino acid sequence of hemocyanin from Bathynomus giganteus a primitive crustacean显示文摘 | Pless D Aguilar M Falcon A | 2003 | Arch Biochem Biophys2003，409，： | 1 |
| 18 | Latent phenoloxidase activity and N-terminal amino acid sequence of hemocyanin from Bathynomus giganteus,a primitive crustacean显示文摘 | Pless D Aguilar M Falcon A | 2003 | Arch Biochem Biophys2003，，409： | 1 |
| 19 | Fatal blunt aortic injuries:a review of 242 autopsy cases显示文摘 | Burkhart HM Gomez GA Jacobson LE Pless JE Broadie TA | | 0，，： | 1 |
| 20 | Linear β-1,3-glucanase are elicitors of defense responses in tobacco显示文摘 | Klarzynaski O Plesse B Joubert J M | 2000 | Plant Physiol2000，124，： | 1 |
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