|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Genome of Cucurbita argyrosperma (Silver- Seed Gourd) Reveals Faster Rates of Protein- Coding Gene and Long Noncoding RNA Turnover and Neofunctionalization within Cucurbita显示文摘Whole-genome duplications are an important source of evolutionary novelties that change the mode and tempo at which genetic elements evolve within a genome. The Cucurbita genus experienced a wholegenome duplication around 30 million years ago, although the evolutionary dynamics of the coding and noncoding genes in this genus have not yet been scrutinized. Here, we analyzed the genomes of four Cucurbita species, in eluding a newly assembled genome of Cucurbita argyrosperma, and compared the gene con tents of these species with those of five other members of the Cucurbitaceae family to assess the evolutionary dynamics of protein-coding and long intergenic noncoding RNA (lincRNA) genes after the genome duplication. We report that Cucurbita genomes have a higher protein-coding gene birth-death rate compared with the genomes of the other members of the Cucurbitaceae family. C. argyrosperma gene families associated with pollination and transmembrane transport had significantly faster evolutionary rates. lincRNA families showed high levels of gene turnover throughout the phylogeny, and 67.7% of the lincRNA families in Cucurbita showed evidence of birth from the neofunctionalization of previously existing protein-coding genes. Collectively, our results suggest that the whole-genome duplication in Cucurbita resulted in faster rates of gene family evolution through the neofunctionalization of duplicated genes. | Josue Barrera-Red on do Enrique Ibarra-Laclette Alejandra Vazquez-Lobo Yocelyn T. Gutierrez-Guerrero Guillermo Sanchez de la Vega Daniel Pinero Salvador Montes-Hernandez Rafael Lira-Saade Luis E. Eguiarte | 2019 | Molecular Plant2019，12，4： | 9 |
| 2 | Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina显示文摘AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical visit.RESULTS A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher mortality.CONCLUSION The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications. | Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2018 | World Journal of Hepatology2018，10，1： | 4 |
| 3 | Intermediate-advanced hepatocellular carcinoma in Argentina:Treatment and survival analysis显示文摘BACKGROUND Hepatocellular carcinoma(HCC) represents the sixteenth most frequent cancer in Argentina. The rise of new therapeutic modalities in intermediate-advanced HCC opens up a new paradigm for the treatment of HCC.AIM To describe real-life treatments performed in patients with intermediateadvanced HCC before the approval of new systemic options.METHODS This longitudinal observational cohort study was conducted between 2009 and2016 in 14 different regional hospitals from Argentina. Included subjects had intermediate-advanced Barcelona Clinic Liver Cancer(BCLC) HCC stages(BCLC B to D). Primary end point analyzed was survival, which was assessed for each BCLC stage from the date of treatment until last patient follow-up or death.Kaplan Meier survival curves and Cox regression analysis were performed, with hazard ratios(HR) calculations and 95% confidence intervals(95%CI).RESULTS From 327 HCC patients, 41% were BCLC stage B, 20% stage C and 39% stage D.Corresponding median survival were 15 mo(IQR 5-26 mo), 5 mo(IQR 2-13 mo)and 3 mo(IQR 1-13 mo)(P < 0.0001), respectively. Among BCLC-B patients(n =135), 57% received TACE with a median number of 2 sessions(IQR 1-3 sessions).Survival was significantly better in BCLC-B patients treated with TACE HR =0.29(CI: 0.21-0.40) than those without TACE. After tumor reassessment by RECIST 1.1 criteria following the first TACE, patients with complete response achieved longer survival (HR = 0.15(CI: 0.04-0.56, P = 0.005))Eighty-two patients were treated with sorafenib, mostly BCLC-B and C(87.8%). However,12.2% were BCLC-D. Median survival with sorafenib was 4.5 mo(IQR 2.3-11.7 mo);which was lower among BCLC-D patients 3.2 mo(IQR 2.0-14.1 mo). A total of 36 BCLC-B patients presented tumor progression after TACE. In these patients,treatment with sorafenib presented better survival when compared to those patients who received sorafenib without prior TACE [HR = 0.26(CI: 0.09-0.71);P= 0.013].CONCLUSION In this real setting, our results were lower than expected. This highlights unmet needs in Argentina, prior to the introduction of new treatments for HCC. | Federico Pinero Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Gustavo Romero Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2019 | World Journal of Gastroenterology2019，25，27： | 3 |
| 4 | Potential of video games for the promotion of neuroadaptation to multifocal intraocular lenses: a narrative review显示文摘Multifocal intraocular lenses(IOLs) are currently usually implanted for the treatment of cataracts because they have been proved to be superior to monofocal IOLs with respect to spectacle independence. In turn, they are associated with a higher prevalence of dysphotopsia symptoms that is one of the most common causes of patient dissatisfaction. Neuroadaptation seems to play a major role in the optimal adaptation to multifocal IOLs. In this context, the development of strategies that facilitate the neuroadaptation process to multifocality might be an effective strategy to reduce patients' dissatisfaction. Video games have been proved to be effective for the improvement of visual acuity and for the promotion of neuroplasticity in elderly subjects and other populations with cortical-related visual impairment. This narrative review highlights the physiological potential of video games as a perceptual strategy to improve visual acuity and promote neuroplasticity in patients using multifocalIOLs, although research is still needed to confirm these benefits in this specific population, with only one comparative study to this date providing evidence of them. | Maria Begona Coco-Martin Pedro LValenzuela Miguel JMaldonado-López Alejandro Santos-Lozano Ainhoa Molina-Martin David P Pinero | 2019 | International Journal of Ophthalmology(English edition)2019，12，11： | 2 |
| 5 | Sequencing of systemic treatment for hepatocellular carcinoma: Second line competitors显示文摘During the last decades,further knowledge of hepatocellular carcinoma(HCC)molecular mechanisms has led to development of effective systemic treatments including tyrosine kinase inhibitors(TKIs)and immunotherapy.In this review,we describe first and second line systemic treatment options for advanced HCC.Several trials have evaluated new drugs for the treatment of HCC patients:In first line,lenvatinib resulted non-inferior to sorafenib and it can be used as alternative,even in the lack of evidence for sequential treatment options in second line after lenvatinib.Recently,atezolizumab plus bevacizumab have shown superiority over sorafenib in first-line.Sorafenib-regorafenib sequential administration in selected patients has opened a new paradigm of treatment in advanced HCC with a life expectancy exceeding two years.Other TKIs for second line treatment include cabozantinib and ramucirumab(specifically for patients with Alpha-fetoprotein values≥400 ng/mL).The combination of TKIs with immunotherapy may represent a big step forward for these patients in the near future. | Federico Pinero Marcelo Silva Massimo Iavarone | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 6 | Liquid metal infiltration into ceramic particle preforms with bimodal size distributions显示文摘 | Molina J M Pinero E Narciso J | 2005 | Current Opinion in Solid State and Mater Sci2005，9，： | 1 |
| 7 | Molecular analysis of rat dentin sialoprotein 显示文摘 | Ritchie HH Pinero GJ Hou H | 1995 | Connect Tissue Res1995，33，13： | 1 |
| 8 | Plant Cd^2+ and Zn^2+ status effects on root and shoot heavy metal accumulation in Thlaspi caerulescens显示文摘 | Papoyan A Pineros M Kochian LV | 2007 | New Phytologist2007，175，1： | 1 |
| 9 | An affine projection algorithm with variable step size and projection order 显示文摘 | GONZALEZ A FERRER M de DIEGO M PINERO G | 2012 | Digital Signal Processing2012，22，58： | 1 |
| 10 | Effect on oximetry of dyes used for sentinel lymph node biopsy 显示文摘 | Pinero A Ulana J Garcia-Pa}enciano C | 2013 | Arch Surg2013，139，11： | 1 |
| 11 | Optical coherence tomography predictive factors for macular hole surgery outcome 显示文摘 | Ruiz-Moreno JM Staicu C Pinero DP | 2008 | Br J Ophthalmol2008，92，5： | 1 |
| 12 | How do crop plants tolerate acid soils? Mechanisms of aluminum tolerance and phosphorous efficiency显示文摘 | Kochian L V Hoekenga O A Pineros M A | 2004 | Annual Review of Plant Biology2004，55，： | 1 |
| 13 | Anterior segment biometry with 2 imaging technologies:very-high-frequency ultrasound scanning versus optical coherence tomography 显示文摘 | Pinero DP Plaza AB Alio JL | 2008 | J Cataract Refract Surg2008，34，1： | 1 |
| 14 | Citric and lactic acids asroot canal irrigants in vitro显示文摘 | Wayman B Kopp WM Pinero GJ | 1979 | J Endod1979，5，9： | 1 |
| 15 | Another major advance in synthetic monofilament absorbable suture 显示文摘 | PINEROS F A DRAKE D B RODEBEAVER P A | 2004 | Journal of Long-Term Effects of Medical Implants2004，14，5： | 1 |
| 16 | Silent cerebral ischemic lesions after carotid artery stenting with cerebral protection显示文摘 | Martinez E Pinero P Gonzalez A | 2005 | Stroke2005，36，： | 1 |
| 17 | AtALMT1, which encodes a malate transporter,is identified as one of several genes critical for aluminum tolerance in Arabidopsis 显示文摘 | Hoekenga O A Maron L G Pineros M A | 2006 | Proc Natl Acad Sci U S A2006，103，： | 1 |
| 18 | How do crop plants tolerate acid soil? Mechanisms of aluminum tolerance and phosphorus efficiency显示文摘 | Kochian L V Hoekenga O A Pineros M A | 2004 | Annual Review Plant Biology2004，55，： | 1 |
| 19 | The physiology and biophysics of an aluminum tolerance mechanism based on root citrate exudation in maize显示文摘 | Pineros MA Magalhaes J V | 2002 | Plant Physiology2002，129，： | 1 |
| 20 | Calcium channels in higher plant cells:Selectivity,regulation and pharmacology 显示文摘 | PINEROS M TESTER M | 1997 | J Exp Bot1997，48，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员