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| 1 | Experience with peritoneal mesothelioma at the Milan National Cancer Institute显示文摘Diffuse malignant peritoneal mesothelioma (DMPM) is an uncommon and rapidly fatal tumor.Therapeutic options have traditionally been limited and ineffective.The biologic and molecular events correlated with poor responsiveness to therapy are still poorly understood.In recent years,an innovative treatment approach involving aggressive cytoreductive surgery (CRS) and perioperative intraperitoneal chemotherapy has reportedly resulted in improved outcome,as compared to historical controls.Since 1995,at the National Cancer Institute (NCI) of Milan (Italy),patients with DMPM have been treated with CRS and hyperthermic intraperitoneal chemotherapy (HIPEC).In the present paper,clinical experiences and basic science investigations on DMPM at Milan NCI are reviewed.Perioperative and long-term outcome results with CRS and HIPEC are presented.Clinico-pathological prognostic factors were investigated by multivariate analysis.The pathologic features and immunohistochemical markers related to DMPM biologic behavior were assessed in a large case-series uniformly treated at our institution.The prevalence and prognostic role of telomere maintenance mechanisms,which account for the limitless cell replicative potential of many malignancies,were studied.The dysregulation of the apoptotic pathways may play a role in the relative chemo-resistance of DMPM and a better understanding of apoptosis-related mechanisms could result in novel targeted therapeutic strategies.On this basis,the expression of survivin and other IAP family members (IAP-1,IAP-2,and X-IAP),the pro-apoptotic protein Smac/DIABLO,and antigens associated with cell proliferation (Ki-67) and apoptosis (caspase-cleaved cytokeratin-18) were analyzed.Finally,analyses of EGFR,PDGFRA and PDGFRB were performed to ascertain if deregulation of RTK could offer useful alternative therapeutic targets. | Marcello Deraco Dario Baratti Antonello Domenico Cabras Nadia Zaffaroni Federica Perrone Raffaella Villa Jenny Jocollè Maria Rosaria Balestra Shigeki Kusamura Barbara Laterza Silvana Pilotti | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 3 |
| 2 | The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response显示文摘Background:Desmoplastic small round cell tumor(DSRCT)is a rare,aggressive,and poorly investigated simple sarcoma with a low frequency of genetic deregulation other than an Ewing sarcoma RNA binding protein 1(EWSR1)-Wilm’s tumor suppressor(WT1)translocation.We used whole-exome sequencing to interrogate six consecutive pretreated DSRCTs whose gene expression was previously investigated.Methods:DNA libraries were prepared from formalin-fixed,paraffin-embedded archival tissue specimens following the Agilent SureSelectXT2 target enrichment protocol and sequenced on Illumina NextSeq 500.Raw sequence data were aligned to the reference genome with Burrows-Wheeler Aligner algorithm.Somatic mutations and copy number alterations(CNAs)were identified using MuTect2 and EXCAVATOR2,respectively.Biological functions associated with altered genes were investigated through Ingenuity Pathway Analysis(IPA)software.Results:A total of 137 unique somatic mutations were identified:133 mutated genes were case-specific,and 2 were mutated in two cases but in different positions.Among the 135 mutated genes,27%were related to two biological categories:DNA damage-response(DDR)network that was also identified through IPA and mesenchymal-epithelial reverse transition(MErT)/epithelial-mesenchymal transition(EMT)already demonstrated to be relevant in DSRCT.The mutated genes in the DDR network were involved in various steps of transcription and particularly affected pre-mRNA.Half of these genes encoded RNA-binding proteins or DNA/RNA-binding proteins,which were recently rec-ognized as a new class of DDR players.CNAs in genes/gene families,involved in MErT/EMT and DDR,were recurrent across patients and mostly segregated in the MErT/EMT category.In addition,recurrent gains of regions in chromosome 1 involving many MErT/EMT gene families and loss of one arm or the entire chromosome 6 affecting relevant immune-regulatory genes were recorded.Conclusions:The emerging picture is an extreme inter-tumor heterogeneity,characterized by the concurrent deregulation of the DDR and MErT/EMT dynamic and plastic programs that could favour genomic instability and explain the refractory DSRCT profile. | Andrea Devecchi Loris De Cecco Matteo Dugo Donata Penso Gianpaolo Dagrada Silvia Brich Silvia Stacchiotti Marialuisa Sensi Silvana Canevari Silvana Pilotti | 2018 | Cancer Communications2018，38，1： | 2 |
| 3 | The expression of MDM2/CDK4 gene product in the differential diagnosis of well differentiated liposarcoma and large deep-seated lipoma显示文摘 | Pilotti S Della Torre G Mezzelani A | 2000 | Br J Cancer2000，82，7： | 1 |
| 4 | Bcl-2 protein expression in carcinomas originating from the follicular epithelium of the thyroid gland显示文摘 | Pilotti S Collini P | 1994 | J Path1994，172，： | 1 |
| 5 | The expression ofMDM2/CDK4 gene product in the differential diagnosis of well dif-ferentiated liposarcoma and large deep-seated lipoma显示文摘 | Pilotti S Della Torre G Mezzelani A | 2000 | Br J Cancer2000，82，7： | 1 |
| 6 | Serum adipokine zinc ct2- glycoprotein and lipolysis in cachectic and noncachectic heart failure patients:relationship with neurohormonal and inflamma- tory biomarkers显示文摘 | Tedeschi S Pilotti E Parenti E ct al | 2012 | Metabolism2012，61，1： | 1 |
| 7 | Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland 显示文摘 | Donghi R Longoni A Pilotti S | 1993 | J Clin Invest1993，91，4： | 1 |
| 8 | Molecular abnormalities in liposarcoma:role of MDM2 and CDK4-containing amplicons at 12q13-22显示文摘 | Pilotti S Della Torre G Lavarino C | 1998 | J Pathol1998，185，2： | 1 |
| 9 | Distributed evaluation of the contribution of soil erosion to the sedimentary yield from a watershed显示文摘 | Bacchi B | 1997 | Earth Surface Processes and Landforms1997，22，13： | 1 |
| 10 | Insular carcinoma: a distinct de novo entity among h)llicular carcinomas of the thyroid gland 显示文摘 | Pilotti S Collini P -Mariani L | 1997 | Am J Surg Pathol1997，21，12： | 1 |
| 11 | Properties of liquid phase pressureless sintered silicon carbide obtained without sintering bed 显示文摘 | GIUSEPPE Magnani LEANDRO Beaulardi LUIGI Pilotti | 2005 | J Euro Ceram Soc2005，25，9： | 1 |
| 12 | Insular carcinoma: adistinct de novo entity among follicular carcinomas of the thyroid gland 显示文摘 | Pilotti S Collini P Mariani L | 1997 | Am J Surg Pathol1997，21，： | 1 |
| 13 | Stable changes in CD4^+ T-lymphocyte microRNA expression following ex posure to HIV l显示文摘 | Bignami F Pilotti E Bertoncelli L | 2012 | Blood2012，119，26： | 1 |
| 14 | Efficient large scale microwave assisted mannich reactions using substituted acetophenones显示文摘 | Lehmann F Pilotti K Luthman K | 2003 | Molecular diversity2003，，7： | 1 |
| 15 | The expression of MDM2/CDK4 gene product in the differential diagonosis of well-differentianted liposareoma and large deep-seated lipoma 显示文摘 | Pilotti S Della Torre G Mezzelani A | 2000 | Br J Cancer2000，82，7： | 1 |
| 16 | Selective activation of ras oncogenes in follicular and undifferentiated thyroid carcinomas 显示文摘 | Manenti G Pilotti S Re FC | 1994 | Eur J Cancer1994，30，7： | 1 |
| 17 | Reconstruction of clastic porous media显示文摘 | Pilotti M | 2000 | Transport inPorous Media2000，41，3： | 1 |
| 18 | Distinct MDM2/P53 expression patterns in liposarcoma subgroups:implications for different pathogenetic mechanism显示文摘 | Pilotti S Della TG Lavarino C | 1997 | J Pathol1997，181，1： | 1 |
| 19 | A comparative study of p53 gene mutations, protein accumulation, and response to cisplatin-based chemotherapy in advanced ovarian carcinoma 显示文摘 | Righetti SC Della TG Pilotti S | 1996 | Cancer Res1996，56，4： | 1 |
| 20 | Bcl-2 protein expression ih carcinomas originating from the follicular epithelium of the thyroid gland显示文摘 | Pilotti S Callini O Kilke F | 1994 | J Pathol1994，172，： | 1 |
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