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| 1 | Induced pluripotent stem cells for modeling neurological disorders显示文摘Several diseases have been successfully modeled since the development of induced pluripotent stem cell(i PSC) technology in 2006. Since then, methods for increased reprogramming efficiency and cell culture maintenance have been optimized and many protocols for differentiating stem cell lines have been successfully developed, allowing the generation of several cellular subtypes in vitro. Gene editing technologies have also greatly advanced lately, enhancing disease-specific phenotypes by creating isogenic cell lines, allowing mutations to be corrected in affected samples or inserted in control lines. Neurological disorders have benefited the most from i PSC-disease modeling for its capability for generating disease-relevant cell types in vitro from the central nervous system, such as neurons and glial cells, otherwise only available from post-mortem samples. Patient-specific i PSC-derived neural cells can recapitulate the phenotypes of these diseases and therefore, considerably enrich our understanding of pathogenesis, disease mechanism and facilitate the development of drug screening platforms for novel therapeutic targets. Here, we review the accomplishments and the current progress in human neurological disorders by using i PSC modeling for Alzheimer's disease, Parkinson's disease, Huntington's disease, spinal muscular atrophy, amyotrophic lateral sclerosis, duchenne muscular dystrophy, schizophrenia and autism spectrum disorders, which include Timothy syndrome, Fragile X syndrome, Angelman syndrome, Prader-Willi syndrome, PhelanMc Dermid, Rett syndrome as well as Nonsyndromic Autism. | Fabiele B Russo Fernanda R Cugola Isabella R Fernandes Graciela C Pignatari Patricia C B Beltrão-Braga | 2015 | World Journal of Transplantation2015，5，4： | 4 |
| 2 | Rapid detec- tion of carbapenemase genes by multiplex real-time PCR 显示文摘 | Monteiro J Widen RH Pignatari AC | 2012 | J Antimicrob Chemother2012，67，4： | 1 |
| 3 | Comparative study of agar diffusion test and the NCCLS macrobroth method for in vitro susceptibility testing of Candida spp显示文摘 | Soni LMF Burattini MN Pignatari ACC | 1999 | Mycopathologia1999，145，3： | 1 |
| 4 | Nosocomial bloodstream infections in Brazilian hospitals:analysis of2,563 cases from a prospective nationwids surveillance study显示文摘 | Marra AR Camargo LF Pignatari AC | 2011 | J Clin microbiol2011，49，5： | 1 |
| 5 | Staphylococcus aureus colonization and infection in patients on continuous ambulatory peritoneal dialysis 显示文摘 | Pignatari A Pfaller M Hollis R | 1990 | J Clin Microbiol1990，28，9： | 1 |
| 6 | Proactive reconciliation as a tool for integrating mining and milling operations显示文摘Historically, reconciliation has been viewed as a quality test of model estimates as well as a powerful tool for detecting and correcting problems in all stages of mine operations from resource estimation to metal production. If used correctly, reconciliation helps to better predict the life of mine(LOM), improves the adherence of production plans to the respective budget, and allows for effective control of the mining and milling processes. However, the accuracy of reconciliation results requires that all input data must be generated in accordance with the principles of sampling correctness. Furthermore, complete reconciliation systems can become extremely complex and must be carefully analyzed in order to provide realistic and helpful conclusions. Based on these concepts, this paper presents a successful proactive reconciliation system applied to a copper and gold mine in Brazil for monitoring and integrating mining and milling operations. | Ana Carolina Chieregati Luiz Eduardo Campos Pignatari Francis Fernand Pitard Homero Delboni Jr | 2019 | International Journal of Mining Science and Technology2019，29，2： | 1 |
| 7 | Changing antimicrobial susceptibility patterns among streptococcus pneumoniae and Haemophilus influenzae from Brazil: Re- port from the SENTRY Antimicrobial Surveillance Pro- gram (1998 -- 2004) 显示文摘 | Castanheira M Gales AC Pignatari AC | 2006 | Microb Drug Resist2006，12，2： | 1 |
| 8 | Nosocomialbloodstream infections in Brazilian hospitals : analysis of 2,563cases from a prospective nationwide surveillance study 显示文摘 | Marra AR Camargo LF Pignatari AC | 2011 | JClin Microbiol2011，49，5： | 1 |
| 9 | Rapid detection of carbapenemase genes by multiplex real-time PCR 显示文摘 | Monteiro J Widen RH Pignatari AC | 2012 | J Antimierob Chemother2012，67，4： | 1 |
| 10 | Acute sinusitis in children-A ret- rospective study of orbital complications显示文摘 | Nero LM Pignatari S Mitsuda S | 2007 | Rev Bras Otorhinolaryngol2007，73，1： | 1 |
| 11 | Nasal septal cross-over flap technique:a choanal atresia micro-endoscopic surgical repair显示文摘 | Stamm AC Pignatari SS | 2001 | Am J Rhinol2001，15，2： | 1 |
| 12 | Nosocomial bloodstream infections in Brazilian hospitals:analysis of 2,563cases from aprospective nationwide surveillance study显示文摘 | Marra AR Camargo LF Pignatari AC | 2011 | J Clin Microbiol2011，49，5： | 1 |
| 13 | Assessment of cognitive learning function in children with obstructive sleep breathing disorders 显示文摘 | HAMASAKI UEMA S F NAGATA PIGNATARI S S FUJITA R R | 2007 | Rev Bras Otorrinolaringol2007，73，： | 1 |
| 14 | Assessment of cognitive learning function in children withobstructive sleep breathing disorders显示文摘 | Hamasaki Uema SF Nagata Pignatari SS Fujitaal | 2007 | Rev Bras Otorrino-laringol2007，73，： | 1 |
| 15 | Dissemination of blaiMP_-carrying integron In 86 among Klebsiella pneumoniae isolates harboring a new trimethoprim resistance gene dfr23显示文摘 | Penteado A P Castanheira M Pignatari A C | 2009 | Diagn Microbiol Infect Dis2009，63，： | 1 |
| 16 | Small hospitals matter:insights from the emergence and spread of vancomycin-resistant Enterococci in 2public hospitals in inner Brazil显示文摘 | Correa AA Pignatari AC da Silveira M | 2015 | Diagn Microbiol Infect Dis2015，82，3： | 1 |
| 17 | Human pap illomavirus infection in pap illomas and nondiseased respiratory sites of patients with recurrent respiratory pap illomatosis using the polymerase chain reaction显示文摘 | Smith EM Pignatari SS Gray SD | 1993 | Arch Otolaryngol Head Neck Surg1993，119，5： | 1 |
| 18 | A tag-less method for direct isolation of human umbilical vein endothelial cells by gravitational field-flow fractionation显示文摘 | Lattuada D Roda B Pignatari C | 2013 | Anal Bioanal Chem2013，405，23： | 1 |
| 19 | Nosoeomial bloodstream infeetions in Brazilian hospitals: analysis of 2,' 563 eases from a prospeetive nationwide surveillance study 显示文摘 | Marra AR Camargo LFA Pignatari ACC | 2011 | Journal of clinical microbiology2011，49，5： | 1 |
| 20 | Transnasal endoscopic surgical approaches to the clivus显示文摘 | Stamm AC Pignatari SS Vellutini E | 2006 | Otolaryngol Clin North Am2006，39，3： | 1 |
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