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| 1 | Role of digital single-operator cholangioscopy in the diagnosis and treatment of biliary disorders显示文摘Due to the need for improvement in the diagnosis and minimally invasive therapy of the bile duct disorders new technologies for cholangioscopy have been recently developed. Per-oral cholangioscopy has become an important diagnostic and therapeutic tool leading to avoidance of aggressive and unnecessary surgery in many clinical scenarios. This paper focuses on the newly developed SpyGlass DS technology, its advantages, and the technique of single-operator cholangioscopy(SOC), biliary indications and possible adverse events. We also review the available literature; discuss the limitations and future expectations.Digital SOC(D-SOC) is a useful technique, which provides endoscopic imaging of the biliary tree, optical diagnosis, biopsy under direct vision and therapeutic interventions. The implementations are diagnostic and therapeutic. Diagnostic indications are indeterminate biliary strictures, unclear filling defects, staging of cholangiocarcinoma, staging of ampullary tumors(extension into the common bile duct), unclear bile duct dilation, exploring cystic lesions of the biliary tree,unexplained hemobilia, posttransplant biliary complications. Therapeutic indications are lithotripsy of difficult stones, retrieval of migrated stents, foreign body removal, guide wire placement, transpapillary gallbladder drainage and endoscopic tumor ablative therapy. Most studied and established indications are the diagnosis of indeterminate biliary stricture and intraductal lithotripsy of difficult stones. The adverse events are not different and more common compared to those of Endoscopic retrograde cholangiopancreatography(ERCP)alone. D-SOC is a safe and effective procedure, adjunct to the standard ERCP and the newly available digital technology overcomes many of the limitations of the previous generations of cholangioscopes. | Petko Karagyozov Irina Boeva Ivan Tishkov | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，1： | 22 |
| 2 | Post-liver transplant biliary complications:Current knowledge and therapeutic advances显示文摘Liver transplantation is the current standard of care for end-stage liver disease and an accepted therapeutic option for acute liver failure and primary liver tumors.Despite the remarkable advances in the surgical techniques and immunosuppressive therapy,the postoperative morbidity and mortality still remain high and the leading causes are biliary complications,which affect up to one quarter of recipients.The most common biliary complications are anastomotic and non-anastomotic biliary strictures,leaks,bile duct stones,sludge and casts.Despite the absence of a recommended treatment algorithm many options are available,such as surgery,percutaneous techniques and interventional endoscopy.In the last few years,endoscopic techniques have widely replaced the more aggressive percutaneous and surgical approaches.Endoscopic retrograde cholangiography is the preferred technique when duct-to-duct anastomosis has been performed.Recently,new devices and techniques have been developed and this has led to a remarkable increase in the success rate of minimally invasive procedures.Understanding the mechanisms of biliary complications helps in their early recognition which is the prerequisite for successful treatment.Aggressive endoscopic therapy is essential for the reduction of morbidity and mortality in these cases.This article focuses on the common post-transplant biliary complications and the available interventional treatment modalities. | Irina Boeva Petko Ivanov Karagyozov Ivan Tishkov | 2021 | World Journal of Hepatology2021，13，1： | 11 |
| 3 | Pharmac ological evaluation of novel Alzheimer' s disease therapeuties: acetylcholinesterase inhibitors related to galanthamine 显示文摘 | Bores G M Huger F P Petko W | 1996 | J Pharm Exp Ther1996，277，2： | 1 |
| 4 | A partionbased approach towards constructing Galois (concept) lattices显示文摘 | Petko Valtchev Rokia Missaoui Pierre Lebrun | 2002 | Discrete Mathematics2002，256，3： | 1 |
| 5 | An auto polyploidy-based genetic algorithm for enhanced evolution of linear polyfractal arrays 显示文摘 | PETKO J S WERNER D H | 2007 | IEEE Trans on Antenas and Propagation2007，55，3： | 1 |
| 6 | CpG island methylation of genes accumulates during the adenoma progression step of the mul- tistep pathogenesis of colorectal cancer 显示文摘 | Kim YH Petko Z Dzieciatkowski S | 2006 | Genes Chromosomes Cancer2006，45，8： | 1 |
| 7 | Aetiology and Management of Chylothorax in Adults显示文摘 | Nair S K Petko M Hayward M P | 2007 | Eur J Cardiothorac Surg2007，32，2： | 1 |
| 8 | Shear stress and pressure modulate saphenous vein remodeling ex vivo 显示文摘 | Gusic RJ Richard Myung hiatus Petko | 2005 | J Biomech2005，38，9： | 1 |
| 9 | Direct evidence of an extensive GABAergic innervation of the spinal doral horn by fibres descending from the rostral ventromedial medulla 显示文摘 | Antal M Petko M Polgar E | 1996 | Neurosci1996，73，2： | 1 |
| 10 | Highly concentrated water-in-oil emulsions: Influence of electrolyte on their properties and stability 显示文摘 | Aronson M P Petko M F | 1993 | J Colloid Interface Sci1993，159，1： | 1 |
| 11 | Solid- phase extraction of berries' anthocyanins and evaluation of their antioxidative properties显示文摘 | Petko Denev Milan Ciz Gabriela Ambrozova | 2010 | Food Chemistry2010，123，5： | 1 |
| 12 | Endoscopic ultrasound-guided biliary drainage-current status and future perspectives显示文摘Endoscopic retrograde cholangiopancreatography(ERCP)with stenting is the treatment modality of choice for patients with benign and malignant bile duct obstruction.ERCP could fail in cases of duodenal obstruction,duodenal diverticulum,ampullary neoplastic infiltration or surgically altered anatomy.In these cases percutaneous biliary drainage(PTBD)is traditionally used as a rescue procedure but is related to high morbidity and mortality and lower quality of life.Endoscopic ultrasound-guided biliary drainage(EUS-BD)is a relatively new interventional procedure that arose due to the development of curvilinear echoendoscope and the various endoscopic devices.A large amount of data is already collected that proves its efficacy,safety and ability to replace PTBD in cases of ERCP failure.It is also possible that EUS-BD could be chosen as a first-line treatment option in some clinical scenarios in the near future.Several EUS-BD techniques are developed EUS-guided transmural stenting,antegrade stenting and rendezvous technique and can be personalized depending on the individual anatomy.EUS-BD is normally performed in the same session from the same endoscopist in case of ERCP failure.The lack of training,absence of enough dedicated devices and lack of standardization still makes EUS-BD a difficult and not very popular procedure,which is related to life-threatening adverse events.Developing training models,dedicated devices and guidelines hopefully will make EUS-BD easier,safer and well accepted in the future.This paper focuses on the technical aspects of the different EUS-BD procedures,available literature data,advantages,negative aspects and the future perspectives of these modalities. | Petko Ivanov Karagyozov Ivan Tishkov Irina Boeva Kiril Draganov | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，12： | 1 |
| 13 | Hemodynamic conditions alter axial and circumferential remodeling of arteries engineered cxvivo 显示文摘 | Nichol J W Petko M Myung R J | 2005 | Ann Biomed Eng2005，33，6： | 1 |
| 14 | Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor/interleukin-6 complex显示文摘 | Ringheim GE Szczepanik AM Petko W | 1998 | Brain Res Mol Brain Res1998，55，1： | 1 |
| 15 | Hemodynamic conditions alter axial and circum/erential remodeling of arteries engineered exvivo显示文摘 | Nichol JW Petko M Myung RJ | 2005 | Ann Biomed Eng2005，33，： | 1 |
| 16 | Miniature reconfigurable three-dimensional fractal tree antennas 显示文摘 | Petko J S Wemer D H | 2004 | IEEE Transactions on Antennas and Propagation2004，52，8： | 1 |
| 17 | IL-4, IL-10 and IL-13 modulate A beta (1-42)-induced cytokine and chemokine poduction inprimary murine microglia and a human monocyte cellline显示文摘 | Szczepanik AM Funes S Petko W | 2001 | J Neuroimmuno2001，113，1： | 1 |
| 18 | The evolution of optimal linear polyfractal arrays using genetic algorithms显示文摘 | Petko J S Werner D H | 2005 | IEEE Transactions on Antennas and Propagation2005，55，11： | 1 |
| 19 | Aetiology and management of chylothorax in adults显示文摘 | Nair S K Petko M Hayward M P | 2007 | Eur J Cardiothorac Surg2007，32，： | 1 |
| 20 | Aberrantly meth- ylated CDKN2A ,MGMT,and MLH1 in colon polyps and in fecal DNA from patients with colorectal polyps 显示文摘 | Petko Z Ghiassi M Shuber A | 2005 | Clin Cancer Res2005，11，： | 1 |
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