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| 1 | Total neoadjuvant therapy vs standard therapy of locally advanced rectal cancer with high-risk factors for failure显示文摘BACKGROUND For locally advanced rectal cancer(LARC),standard therapy[consisting of neoadjuvant chemoradiotherapy(CRT),surgery,and adjuvant chemotherapy(ChT)]achieves excellent local control.Unfortunately,survival is still poor due to distant metastases,which remains the leading cause of death among these patients.In recent years,the concept of total neoadjuvant treatment(TNT)has been developed,whereby all systemic ChT-mainly affecting micrometastases-is applied prior to surgery.AIM To compare standard therapy and total neoadjuvant therapy for LARC patients with high-risk factors for failure.METHODS In a retrospective study,we compared LARC patients with high-risk factors for failure who were treated with standard therapy or with TNT.High-risk for failure was defined according to the presence of at least one of the following factors:T4 stage;N2 stage;positive mesorectal fascia;extramural vascular invasion;positive lateral lymph node.TNT consisted of 12 wk of induction ChT with capecitabine and oxaliplatin or folinic acid,fluorouracil and oxaliplatin,CRT with capecitabine,and 6-8 wk of consolidation ChT with capecitabine and oxaliplatin or folinic acid,fluorouracil and oxaliplatin prior to surgery.The primary endpoint was pathological complete response(pCR).In total,72 patients treated with standard therapy and 89 patients treated with TNT were included in the analysis.RESULTS Compared to standard therapy,TNT showed a higher proportion of pCR(23%vs 7%;P=0.01),a lower neoadjuvant rectal score(median:8.43 vs 14.98;P<0.05),higher T-and N-downstaging(70%and 94%vs 51%and 86%),equivalent R0 resection(95%vs 93%),shorter time to stoma closure(mean:20 vs 33 wk;P<0.05),higher compliance during systemic ChT(completed all cycles 87%vs 76%;P<0.05),lower proportion of acute toxicity grade≥3 during ChT(3%vs 14%,P<0.05),and equivalent acute toxicity and compliance during CRT and in the postoperative period.The pCR rate in patients treated with TNT was significantly higher in patients irradiated with intensity-modulated radiotherapy/volumetricmodulated arc radiotherapy than with 3D conformal radiotherapy(32%vs 9%;P<0.05).CONCLUSION Compared to standard therapy,TNT provides better outcome for LARC patients with high-risk factors for failure,in terms of pCR and neoadjuvant rectal score. | Mojca Tuta Nina Boc Erik Brecelj Monika Peternel Vaneja Velenik | 2021 | World Journal of Gastrointestinal Oncology2021，13，2： | 3 |
| 2 | Ability of Lactobacillus gasseri K7to inhibit Escherichia coli adhesion in vitro on Caco-2cells and ex vivo on pigs’jejunal tissue显示文摘 | Matijasic B B Narat M Peternel M Z | 2006 | Int J Food Microbiol2006，107，1： | 1 |
| 3 | The influence of sequence variations in factor VII, γ-glutamylcarboxylase and vitamin K epoxide reductase complex genes on warfarin dose requirement显示文摘 | HERMAN D PETERNEL P STEGNAR M | 2006 | Thromb Haemost2006，95，5： | 1 |
| 4 | Towards a Mori theory on compact Kahler threefolds Ⅱ显示文摘 | | 1998 | Math Ann1998，311，： | 1 |
| 5 | Iron-Activated Persuliate Oxidation of an Azo Dye in Model Wastewater: Influence of Iron Acti- vator Type on Process Optimization 显示文摘 | Kusic H Peternel I Koprivanac N | 2011 | Journal Of Environmental Engineering-ASCE2011，137，6： | 1 |
| 6 | Incidence of betulaceaepollen and pollinosis in Zagreb, Croatia, 2OO2-2OO5显示文摘 | Peternel R Milanovic SM Hrga I | 2007 | Ann Agric Environ Med2007，14，1： | 1 |
| 7 | A new approach to crystal- lographic orientation measurement for apatite fission track analysis, Effects of crystal morphology and implications for automation显示文摘 | Peternell M Kotdmann Fabian Wilson C J L Seiler Christian Gleadow A J W | 2009 | Chemical Geology2009，265，： | 1 |
| 8 | Intraocular lens movement caused by ciliary musacle contraction 显示文摘 | Findl O Kiss B Peternel V | 2003 | Cataract Refract Surg2003，29，： | 1 |
| 9 | Adsorption of Cd ( II ) and Pb ( II ) onto functionalized formic lignin from sugar cane bagasse 显示文摘 | PETERNELE W S WINKLER-HECHENLEITNER A A PINEDA E A G | 1999 | Bioresour Technol1999，68，： | 1 |
| 10 | Incidence of Betulaceae pollen and pollinosis in Zagreb,Croatia,2002-2005显示文摘 | Peternel R Milanovic'SM Hrga I | 2007 | Ann Agric Environ Med2007，14，1： | 1 |
| 11 | Comparative study of UV/Ti02,UV/ZnO and photo-Fenton processes for the organic reactive dye degrada-tion in aqueous solution 显示文摘 | PETERNEL I T KOPRIVANAC N BOZIC AML etal | 2007 | J Hazard Mater2007，148，： | 1 |
| 12 | Adsorption of CA ( Ⅱ ) and Pb ( Ⅱ ) onto functionalized formic lignin from sugar cane bagasse显示文摘 | Peternele W S Winkler-Hechenleimer Ana A Gomez P | 1999 | Bioresource Technology1999，68，： | 1 |
| 13 | Comparative study of UV/TiO2,UV/ZnO and photo-Fenton processes for the organic reactive dye degradation in aqueous solution显示文摘 | PETERNEL I T KOPRIVANAC N ANA M L | 2007 | Journal of Hazardous Materials2007，148，： | 1 |
| 14 | An introduction for line geometry with applications显示文摘 | Pottmann H Peternell M Ravani H | 1999 | CAD1999，31，1： | 1 |
| 15 | Incidence of Betulaceae pollen and pollinosis in ga- greb, Croatia, 2002-2005显示文摘 | PETERNEL R MILANOVIC S M HRGA I | 2007 | Ann Agric Environ Med2007，14，： | 1 |
| 16 | Artificial Neural Network Models for Advanced Oxidation of Organics in Water Matrix-Comparison of Applied Methodologies显示文摘 | Bolanca T Ukic S Peternel I | 2014 | Indian J Chem Techn2014，21，1： | 1 |
| 17 | Incidence of bet ulaeeae pollen and pollinosis in Zagreb, Croatia, 2002 2005 显示文摘 | Peternel R Milanovic SM Hrga I | 2007 | Ann Agric Environ Med2007，14，1： | 1 |
| 18 | Reconstruction of Piecewise Planar Objects from Point Clouds显示文摘 | Peternell M Steiner T | | 0，，04： | 1 |
| 19 | Ability of Lactobacillus gasseri K7 to inhibit Escherichia coli adhesion in vitro on CaCo-2 cells and ex vivo on pigs'jejunal tissue显示文摘 | Bogovic B Narat M M Peternel M Z | 2006 | International Journal of Food Microbiology2006，107，： | 1 |
| 20 | A novel sequence variant in exon7 of CYP2C9 gene (CYP2C9^*24) in a patient on war latin therapy 显示文摘 | Herman D Peternel P Stegnar M | 2006 | Thromb Haemost2006，95，1： | 1 |
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