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| 1 | Neuroendocrine tumors of the gastro-entero-pancreatic system显示文摘Gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs) are rare neoplasms, although their prevalence has increased substantially over the past three decades. Moreover, there has been an increased clinical recognition and characterization of these neoplasms. They show extremely variable biological behavior and clinical course. Most NETs have endocrine function and secrete peptides and neuroamines that cause distinct clinical syndromes, including carcinoid syndrome; however, many are clinically silent until late presentation with mass effects. Investigation and management should be individualized for each patient, taking into account the likely natural history of the tumor and general health of the patient. Management strategies include surgery for cure or palliation, and a variety of other cytoreductive techniques, and medical treatment including chemotherapy, and biotherapy to control symptoms due to hormone release and tumor growth, with somatostatin analogues (SSAs) and alphainterferon. New biological agents and somatostatintagged radionuclides are under investigation. Advances in the therapy and development of centers of excellence which coordinate multicenter studies, are needed to improve diagnosis, treatment and therefore survival of patients with GEP NETs. | Sara Massironi Valentina Sciola Maddalena Peracchi Clorinda Ciafardini Matilde Pia Spampatti Dario Conte | 2008 | World Journal of Gastroenterology2008，14，35： | 44 |
| 2 | Gastric carcinoids:Between underestimation and overtreatment显示文摘Gastric carcinoids(GCs),which originate from gastric enterochromaffin-like(ECL) mucosal cells and account for 2.4% of all carcinoids,are found increasingly in the course of upper gastrointestinal tract endoscopy.Current nosography includes those occurring in chronic conditions with hypergastrinemia,as the type 1 associated with chronic atrophic gastritis,and the type 2 associated with Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1,and type 3,which is unrelated to hypergastrinemia and is frequently malignant,with distant metastases.The optimal clinical approach to GCs remains to be elucidated,depending upon type,size and number of carcinoids.While there is agreement concerning the treatment of type 3 carcinoids,for types 1 and 2,current possibilities include simple surveillance,endoscopic polypectomy,surgical excision,associated or not with surgical antrectomy,or total gastrectomy.Moreover,the recent introduction of somatostatin analogues represents a therapeutic option of possibly outstanding relevance. | Sara Massironi Valentina Sciola Matilde Pia Spampatti Maddalena Peracchi Dario Conte | 2009 | World Journal of Gastroenterology2009，15，18： | 10 |
| 3 | Circulating ghrelin levels in celiac patients 显示文摘 | Peracchi M Conte D Terrani C | 2003 | Am J Gastroenterol2003，98，11： | 1 |
| 4 | Circulating ghrelin levels in patients with inflammatory bowel disease 显示文摘 | Peracchi M Bardella MT Caprioli F | 2006 | Gut2006，55，3： | 1 |
| 5 | Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate 显示文摘 | Wang S Karbstein K Peracchi A | 1999 | Biochemistry1999，38，14： | 1 |
| 6 | Plasma chromogranin A in patients with autoimmune chronic atrophic gastritis,enterochromaffin-like cell lesions and gastric carcinoids显示文摘 | Peracchi M Gebbia C Basilisco G | 2005 | Eur J Endocrinol2005，152，3： | 1 |
| 7 | A genomic overview of pyridoxal-phosphate-dependent enzymes显示文摘 | PERCUDANI R PERACCHI A | 2003 | EMBO Reports2003，4，9： | 1 |
| 8 | DNA catalysis: potential, limitations, open questions显示文摘 | Peracchi A | 2005 | Chem Bio Chem2005，6，8： | 1 |
| 9 | Domain organization of phytochelatln synthase显示文摘 | Ruotolo R Peracchi A Bolchi A | 2004 | The Journal of Biological Chemistry2004，279，14： | 1 |
| 10 | Postprandial gut peptide plasma levels in women with idiopathic slow-transit constipation显示文摘 | Peracchi M Basilisco G Tagliabue R | | 0，，： | 1 |
| 11 | Postprandial gut peptide plasma levels inwoman with idiopathic slow transit constipation显示文摘 | Peracchi M Basilisco G Tagliabue R | 1999 | Scand J Gastroenterol1999，34，1： | 1 |
| 12 | Gastric emptying and plasma neurotensin levels in untreated celiac patients显示文摘 | Bardella M T Fraquelli M Peracchi M | 2000 | Scandinavian journal of gastroenterology2000，35，3： | 1 |
| 13 | Domain organization of phytochelatin synthase-functional properties of truncated en- zyme species identified by limited proteolysis显示文摘 | RUOTOLO R PERACCHI A BOLCHI A | 2004 | The Journal of Biological Chemistry2004，279，14： | 1 |
| 14 | Post-prandial gut peptide plasma levels in women with idiopathic slow-transit constipation 显示文摘 | Peracchi M Basilisco G Tagliabue R | 1999 | Scand J Gastroenterol1999，34，1： | 1 |
| 15 | Plasma chromogranin A in patients with autoimmune chronic atrophic gastritis,enterochromaffin like cell lesions and gastric carcinoids显示文摘 | Peracchi M Gebbia C Basilisco G | 2005 | EurJ Endocrinol2005，152，3： | 1 |
| 16 | Serum 25-hydroxyvitamin D and biochemical markers of bone metabolism in patients with juvenile idiopathic arthritis显示文摘 | Munekata RV Terreri MT Peracchi OA | 2013 | Braz J Med Biol Res2013，46，1： | 1 |
| 17 | Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate 显示文摘 | Wang S Karbstein K Peracchi A | 1999 | Biochemistry1999，38，14： | 1 |
| 18 | Plasma chromogranin A in patients with autoimmune chronic atrophic gastritis, enteroehromaffin-like cells lesions and gastric carcinoids显示文摘 | Peracchi M Gebbia O Basilisco G | 2005 | Euro J Endocri2005，152，3： | 1 |
| 19 | The Future of Pensions in Europe显示文摘 | Boldrin M Dolado J J Jimeno J F Peracchi F | 1999 | Economic Policy1999，，： | 1 |
| 20 | Human cobalamin deficiency: alterations in serum tumour necrosis faetor-ct and epidermal growth factor 显示文摘 | Peracchi M Bamonti Catena F Pomati M | 2001 | Eur J Haematol2001，67，2： | 1 |
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