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| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | Structural and functional features of different types of cytoplasmic fatty acid-binding proteins显示文摘 | Veerkamp J H Peeters R A Maatman R G H J | 1991 | Biochim Biophys Aeta1991，1081，1： | 1 |
| 3 | Outpatient laparoscopic cholecystecto-my:clinical pathway implementation is efficient and cost effective and increases hospital bed capacity显示文摘 | Topal B Peeters G Verbert A | 2007 | Surg Endosc2007，21，7： | 1 |
| 4 | Rescue of Newcastle disease virus from cloned cDNA:Evidence that cleavability of the Fusion protein is a major determinant for virulence显示文摘 | Peeters B P de Leeuw O S Koch G | 1999 | J Virol1999，73，6： | 1 |
| 5 | Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers 显示文摘 | Cammu G De Kam PJ Demeyer I Decoopman M Peeters PA Smeets JM | 2008 | Br J Anaesth2008，100，3： | 1 |
| 6 | Synthesis of 1-deoxymannojirimycin analogues using N-tosyl and N-nosyl activated aziridines derived {rom 1 amino 1-deoxyglucitol显示文摘 | Mao H Joly G J Peeters K | 2001 | Tetrahedron2001，57，： | 1 |
| 7 | Reference-based stochas-tic subspace identification for output-only modal analy-sis 显示文摘 | PEETERS B ROECK G D | 1999 | Mechanical Systems and Signal Processing1999，，6： | 1 |
| 8 | Rescue of Newcastle disease virus from cloned cDNA:evidence that cleavability of the fusion protein is a major determinant for virulence显示文摘 | Peeters B P H de Leeuw O S Koch G | 1999 | J Virol1999，73，： | 1 |
| 9 | Reference based stochastic sub-space identification for output-only modal analysis 显示文摘 | Peeters B De Roeck G | 1999 | Mechanical Systems and Signal Processing1999，13，6： | 1 |
| 10 | Struture-activity relati on oferythromycin-related macrolides in inducing contractions and in displacin g bound motilinin rabbit duodenum显示文摘 | Deportere I Peeters T Mattkijs G | 1989 | J Gastrointest Motil1989，1，： | 1 |
| 11 | Infectious bursal disease virus capsid protein VP3 interacts with VP1, the RNA-dependent RNA polymerase, and with viral double-stranded RNA显示文摘 | TACKEN M G PEETER B P THOMAS A A | 2002 | J Virol2002，77，11： | 1 |
| 12 | Personality and Team Performance : A Meta - Analysis 显示文摘 | Miranda A G Peeters Harrie F J M Vantuijl Christel G Rutte Isabelle M M J Reymen | 2006 | European Journal of Personality2006，，20： | 1 |
| 13 | Vibration- based Damage Detection in Civil Engineering: Excita- tion Sources and Temperature Effectst显示文摘 | PEETERS B MAECK J DE ROECK G | 2001 | Smart Ma terial and Structures2001，10，3： | 1 |
| 14 | Erythromycin impromives delayed gastricemptying in diabetic gastroparesis显示文摘 | Janssens J Peeters T Van Trappen G | 1990 | N Engl J Med1990，322，： | 1 |
| 15 | Rescue of newcastle disease virus from cloned cDNA: evidence that cleavability of the fusion protein is a major determinant for virulence显示文摘 | Peeters P H de Leeuw O S Koch G | 1999 | J Virol1999，73，6： | 1 |
| 16 | Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE) 显示文摘 | Raaschou-Nielsen 0 Andersen ZJ Beelen R Samoli E Stafoggia M Weinmayr G Hoffmann B Fischer P Nieuwenhuijsen MJ Brunekreef B Xun WW Katsouyanni K Dimakopoulou K Sommar J Forsberg B Modig L Oudin A Oftedal B Schwarze PE Nafstad p De Faire U Pedersen NL Ostenson CG Fratiglioni L Penell J Korek M Pershagen G Eriksen KT Serensen M Tjenneland A Ellermann T Eeftens M Peeters PH Meliefste K Wang M Bueno-de-Mesquita B Key TJ de Hoogh K Concin H Nagel G Yilier A Grioni S Krogh y Tsai MY Ricceri F Sacerdote C Galassi C Migliore E Ranzi A Cesaroni G Badaloni C Forastiere F Tamayo I Amiano P Dorronsoro M Trichopoulou A Bamia C Yineis p Hoek G | 2013 | Lancet Oncol2013，14，9： | 1 |
| 17 | Outpatient laparoscopic Cholecysttectomy: clinical pathway implementation is efficient and costeffective and increases hospital bed capacity显示文摘 | Topal B Peeters G | 2007 | Surg eddosc2007，21，7： | 1 |
| 18 | Preference-based stochastic subspace identification for output-only modal analysis显示文摘 | Peeters B and Roeck G D | 1999 | Mechanical Systems and Signal Processing1999，13，： | 1 |
| 19 | Rescue of Newcas- tle Disease Virus from cloned cDNA: evidence that cleavability of the fusion protein is a major determinant for virulence显示文摘 | Peeters B P H De Leeuw O S Koch G | 1999 | J Virol1999，73，6： | 1 |
| 20 | Reference-based stochasticsubspace identification for output-only modal analysis显示文摘 | Peeters B De Roeck G | 1999 | Mechanical Systems and Signal Processing1999，13，6： | 1 |
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