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| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | Proliferating cell nuclear antigen(PCNA):a new marker to study human colonic cell proliferation显示文摘 | Kubben FJ Peeters H Aesevoets A | 1994 | Gut1994，35，4： | 2 |
| 3 | Structural and functional features of different types of cytoplasmic fatty acid-binding proteins显示文摘 | Veerkamp J H Peeters R A Maatman R G H J | 1991 | Biochim Biophys Aeta1991，1081，1： | 1 |
| 4 | Outpatient laparoscopic cholecystecto-my:clinical pathway implementation is efficient and cost effective and increases hospital bed capacity显示文摘 | Topal B Peeters G Verbert A | 2007 | Surg Endosc2007，21，7： | 1 |
| 5 | Risk factors foranastootic failure after total mesorectal excision of rectal cancer显示文摘 | Peeters K C Tollenaar R A Marijnen C A | 2005 | British Journal of Surgery2005，11，15： | 1 |
| 6 | Determination of the number of automated guided vehicles required at a semi-automated container terminal显示文摘 | Vis I F A de Koster R Roodbergen K J Peeters L W P | 2001 | Journal of the operation research society2001，52，： | 1 |
| 7 | Infectious bursal disease virus capsid protein VP3 interacts with VP1, the RNA-dependent RNA polymerase, and with viral double-stranded RNA显示文摘 | TACKEN M G PEETER B P THOMAS A A | 2002 | J Virol2002，77，11： | 1 |
| 8 | Personality and Team Performance : A Meta - Analysis 显示文摘 | Miranda A G Peeters Harrie F J M Vantuijl Christel G Rutte Isabelle M M J Reymen | 2006 | European Journal of Personality2006，，20： | 1 |
| 9 | The Arabi- dopsis aldehyde oxidase 3 (AAO3) gene productcatalyzes the final step in abseisic acid biosynthesis in leaves 显示文摘 | Seo M Peeters A J Koiwai H | 2000 | Proc Natl Acad Sci2000，97，12： | 1 |
| 10 | Randomized phase Ⅲ study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second- line treatment in patients with meta- static colorectal cancer 显示文摘 | Peeters M Price TJ Cervantes A | 2010 | J Clin Oncol2010，28，31： | 1 |
| 11 | Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE) 显示文摘 | Raaschou-Nielsen 0 Andersen ZJ Beelen R Samoli E Stafoggia M Weinmayr G Hoffmann B Fischer P Nieuwenhuijsen MJ Brunekreef B Xun WW Katsouyanni K Dimakopoulou K Sommar J Forsberg B Modig L Oudin A Oftedal B Schwarze PE Nafstad p De Faire U Pedersen NL Ostenson CG Fratiglioni L Penell J Korek M Pershagen G Eriksen KT Serensen M Tjenneland A Ellermann T Eeftens M Peeters PH Meliefste K Wang M Bueno-de-Mesquita B Key TJ de Hoogh K Concin H Nagel G Yilier A Grioni S Krogh y Tsai MY Ricceri F Sacerdote C Galassi C Migliore E Ranzi A Cesaroni G Badaloni C Forastiere F Tamayo I Amiano P Dorronsoro M Trichopoulou A Bamia C Yineis p Hoek G | 2013 | Lancet Oncol2013，14，9： | 1 |
| 12 | Spectrum of transient focal neurological episodes in cerebral amyloid angiopathy: muhicentre magnetic resonance imaging co- hort study and meta-analysis 显示文摘 | Charidimou A Peeters A Fox Z | 2012 | Stroke2012，43，9： | 1 |
| 13 | Carbohy-drate metabolism is perturbed in peroxisome - deficient hepatocytesdue to mitochondrial dysfunction,AMP ~ activated protein kinase(AMPK) activation, and peroxisome proliferator - activated recep-tor y coactivator la ( PGC - la) suppression显示文摘 | PEETERS A FRAISL P VAN DEN BERG S | 2011 | J Biol Chem2011，286，42： | 1 |
| 14 | Ralstonia solanacearum, a widespread bacterial plant pathogen in the post-genomic era显示文摘 | Peeters N Guidot A | 2013 | Molec- ular Plant Pathology2013，14，7： | 1 |
| 15 | The transparent testa 12 gene of Arabidopsis encodes a multidrug secondary transporter- like protein required for flavonoid sequestration in vacuoles of the seed coat endothelium显示文摘 | Debeaujon I Peeters A J M Leon-Kloosterziel K M | 2001 | The Plant Cell2001，13，： | 1 |
| 16 | Identification of the impedance medel of an implanted cochlear prosthesis from intracochlear potential measurements显示文摘 | VANPOUCKE FJ ZAROWSKI A J PEETERS SA | 2004 | IEEE Trans Biomed Eng2004，51，12： | 1 |
| 17 | Spectral properties of classical two-dimensional clusters显示文摘 | Schweigert V A Peeters F M | 1995 | Phys Rev B1995，51，： | 1 |
| 18 | Radial-Fluctuation-Induced Stabilization of the Ordered State in Two-Dimensional Classical Clusters显示文摘 | SCHWEIGERT I V SCHWEIGERT V A PEETERS F M | 2000 | Phys Rev Lett2000，84，19： | 1 |
| 19 | Carbohydrate metabolism is perturbed in peroxisome-defi- cient hepatocytes due to mitochondrial dysfunction, AMP- activated protein kinase (AMPK) activation, and peroxi- some proliferator-activated receptor / coactivator lot (PGC-lot) suppression 显示文摘 | PEETERS A FRAISL P VANDEN BERG S | 2011 | J Biol Chem2011，286，42： | 1 |
| 20 | Randomizedphase HI study of panitumumab with fluorouracil,leu-covorin, and irinotecan (FOLFIRI) compared withFOLFIRI alone as second-line treatment in patients withmetastatic colorectal cancer显示文摘 | Peeters M Price TJ Cervantes A | 2010 | J Clin Oncol2010，28，31： | 1 |
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