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| 1 | 长江三峡库区地质灾害遥感图像信息处理及其监测和评估显示文摘长江三峡作为世界上最大的水利工程,引起了世界的广泛关注。水库堤岸的长度、水库容载力、三峡移民数量以及其对生态环境的影响都成为议论的焦点。最引人注目的是长江两岸存在大量的地质灾害,如:滑坡、崩塌等,其中有些大型灾害体目前仍处于活动状态,这将给三峡工程的安全与库岸稳定性以及库区生态环境带来深远的影响。因此,采用3S和多时相TM、SPOT、ERS-SAR和RADARSAT等图像集成新技术来快速有效地监测、研究和评估地质灾害对三峡工程以及周边环境的影响,为地质灾害的预防和治理提供科学依据,本成果具有重要的学术意义和实用价值。 | 杨武年 濮国梁 CAUNEAU F RANCHIN T PARIS J P | 2005 | 地质学报2005，79，3： | 30 |
| 2 | Defining response to radiotherapy in rectal cancer using magnetic resonance imaging and histopathological scales显示文摘AIM To define good and poor regression using pathology and magnetic resonance imaging(MRI) regression scales after neo-adjuvant chemotherapy for rectal cancer.METHODS A systematic review was performed on all studies up to December 2015, without language restriction, t h a t w e r e i d e n t i f i e d f r o m M E D L I N E, C o c h r a n e Controlled Trials Register(1960-2015), and EMBASE(1991-2015). Searches were performed of article bibliographies and conference abstracts. MeS H and text words used included 'tumour regression', 'mr TRG', 'poor response' and 'colorectal cancers'. Clinical studies using either MRI or histopathological tumour regression grade(TRG) scales to define good and poor responders were included in relation to outcomes [local recurrence(LR), distant recurrence(DR), disease-free survival(DFS), and overall survival(OS)]. There was no age restriction or stage of cancer restriction for patient inclusion. Data were extracted by two authors working independently and using pre-defined outcome measures.RESULTS Quantitative data(prevalence) were extracted and analysed according to meta-analytical techniques using comprehensive meta-analysis. Qualitative data(LR, DR, DFS and OS) were presented as ranges. The overall proportion of poor responders after neo-adjuvant chemoradiotherapy(CRT) was 37.7%(95%CI: 30.1-45.8). There were 19 different reported histopathological scales and one MRI regression scale(mrT RG). Clinical studies used nine and six histopathological scales for poor and good responders, respectively. All studies using MRI to define good and poor response used one scale. The most common histopathological definition for good response was the Mandard grades 1 and 2 or Dworak grades 3 and 4; Mandard 3, 4 and 5 and Dworak 0, 1 and 2 were used for poor response. For histopathological grades, the 5-year outcomes for poor responders were LR 3.4%-4.3%, DR 14.3%-20.3%, DFS 61.7%-68.1% and OS 60.7-69.1. Good pathological response 5-year outcomes were LR 0%-1.8%, DR 0%-11.6%, DFS 78.4%-86.7%, and OS 77.4%-88.2%. A poor response on MRI(mr TRG 4,5) resulted in 5-year LR 4%-29%, DR 9%, DFS 31%-59% and OS 27%-68%. The 5-year outcomes with a good response on MRI(mrT RG 1,2 and 3) were LR 1%-14%, DR 3%, DFS 64%-83% and OS 72%-90%.CONCLUSION For histopathology regression assessment, Mandard 1, 2/Dworak 3, 4 should be used for good response and Mandard 3, 4, 5/Dworak 0, 1, 2 for poor response. MRI indicates good and poor response by mr TRG1-3 and mrT RG4-5, respectively. | Muhammed RS Siddiqui Jemma Bhoday Nicholas J Battersby Manish Chand Nicholas P West Al-Mutaz Abulafi Paris P Tekkis Gina Brown | 2016 | World Journal of Gastroenterology2016，22，37： | 6 |
| 3 | Risk-adjustment in hepatobiliarypancreatic surgery显示文摘AIM: The present study evaluates the performance of the POSSUM, the American Society of Anesthetists (ASA),APACHE and Childs classification in predicting mortality and morbidity in hepatopancreaticobiliary (HPB) surgery.We describe especially the limitations and advantages of risk in stratifying the patients.METHODS: We investigated 177 randomly chosen patients undergoing eledive complex HPB surgery in a single institution with a total of 71 pre-operative and intra-operative risk factors.Primary endpoint was in-hospital mortality and morbidity.Ordered logistic regression analysis was used to identify individual predictors of operative morbidity and mortality.RESULTS: The operative mortality in the series was 3.95% .This compared well with the p-POSSUM and APACHE predicted mortality of 4.31% and 4.29% respectively. Postoperative complications amounted to 45% with 24 (13.6%)patients having a major adverse event. On multivariate analysis the pre-operative POSSUM physiological score (OR = 1.18,P = 0.009) was superior in predicting complications compared to the ASA (P = 0.108), APACHE (P = 0.117)or Childs classification (P = 0.136). In addition, serum sodium, creatinine, international normalized ratio (INR),pulse rate, and intra-operative blood loss were independent risk factors. A combination of the POSSUM variables and INR offered the optimal combination of risk factors for risk prognostication in HPB surgery.CONCLUSION: Morbidity for elective HPB surgery can be accurately predicted and applied in everyday surgical practice as an adjunct in the process of informed consent and for effective allocation of resources for intensive and high-dependency care facilities. | Hemant M Kocher Paris P Tekkis Palepu Gopal Ameet G Patel Simon Cottam Irving S Benjamin | 2005 | World Journal of Gastroenterology2005，11，16： | 3 |
| 4 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 5 | A Critical Analysis of Crack Propagation Laws显示文摘 | Paris P C Erdogan F | 1963 | Journal of Basic Engineering ASME (SeriesD)1963，85，： | 1 |
| 6 | Stimulation of respiration by Pb^2+ in detached leaves and mitochondria of C3 and C4 plants 显示文摘 | Romanowska E Igamberdiev Au Pary S E Gardestrom P | 2002 | Physiol Plant2002，116，2： | 1 |
| 7 | A critical analysis of crack propagation laws 显示文摘 | Paris P C Erdogen F | 1963 | Journal of Basic Engineering Transactions ASME Series D1963，85，3： | 1 |
| 8 | A critical analysis of crack propagation laws显示文摘 | Paris P C Erdogan F | 1963 | Journal of Basic Engineering1963，，85： | 1 |
| 9 | Deficits in saccadic eye-movement control in Parkinson's disease 显示文摘 | Chan F Armstrong IT Pari G Riopelle P J Munoz DE 2005 | 2005 | Neuropsychologia2005，43，： | 1 |
| 10 | Overexpression of torsinA in PC12 cells protects against toxicity显示文摘 | Shashidharan P Paris N Sandu D | 2004 | Journalof Neurochemistry2004，88，4： | 1 |
| 11 | Dexmedetomidine in anaesthesia 显示文摘 | Paris A Tonner P H | 2005 | Curr Opin Anaesthesiol2005，18，4： | 1 |
| 12 | Antihyperlipidemic effect of chlorogenic acid and tetrahydrocureumin in rats subjected to dia- betogenic agents 显示文摘 | K Karthikesan L Pari V P Menon | 2010 | Chemico Biological Interact2010，188，3： | 1 |
| 13 | Cardiac autonomic neuropathy in diabetic patients: influence of diabetes duration, obesity, and microangiopathic complications-the French muhicenter study 显示文摘 | Valensi P Pariès J Attali JR | 2003 | Metabolism2003，52，： | 1 |
| 14 | Elastic field equations for blunt cracks with reference to stress corrosion cracking 显示文摘 | Creager M Paris P C | 1967 | International Journal of Fracture Mechanics1967，3，： | 1 |
| 15 | Two distinct tumor suppressor loci within chromosome 11P15 implicated In breast cancer progression and maetstasis显示文摘 | Kamik P Paris M Williajns B | 1998 | Hum Mol Genet1998，7，： | 1 |
| 16 | HVDC conversion of HVAC lines to provide substantial power upgrading显示文摘 | Clerici A Paris L Danfors P | 1991 | IEEE Transactions on Power Delivery1991，6，1： | 1 |
| 17 | A rational analytic theory of fatigue显示文摘 | PARIS P C GOMEZ M P ANDERSON W P | 1961 | The Trend in Engineering1961，，13： | 1 |
| 18 | Anatomic and functional results in 156 cases and are view of the literature 显示文摘 | Paris H Tropiano P Clouet D Fractures of the shaft of the humerus: systematic plate fixation | 2000 | Rev Chir Orthop Reparatrice Appar Mot2000，86，4： | 1 |
| 19 | Elastic field equations for blunt cracks with reference to stress corrosion cracking显示文摘 | Creager M Paris P C | 1967 | International Jour- nal of Fatigue1967，3，： | 1 |
| 20 | Pain after laparoscopic cholecystectomy:characteristics and effect of intraperitoneal bupivacaine显示文摘 | Joris J Thiry E Paris P | 1995 | Anesth Analg1995，81，： | 1 |
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