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| 1 | Overexpression of Slug is associated with malignant progression of esophageal adenocarcinoma显示文摘AIM: To characterise expression of known E-cadherin repressors; Snail, Slug and Twist in the development of esophageal adenocarcinoma. METHODS: E-cadherin, Slug, Snail and Twist mRNA expression in Barrett's metaplasia and esophageal adenocarcinoma specimens was examined by real-time reverse transcription-polymerase chain reaction (RT-PCR). Semi-quantitative immunohistochemistry was used to examine cellular localisation and protein levels. The effect of Slug on epithelial mesenchymal transition (EMT) markers was examined by transfection of Slug into an adenocarcinoma line OE33.RESULTS: Cellular localisation of Slug in Barrett's metaplasia was largely cytoplasmic whilst in adenocarcinoma it was nuclear. Semi-quantitative analysis indicated that Slug was more abundant in adenocarcinoma compared to matched Barrett's metaplastic specimens. Snail and Twist were expressed in adenocarcinoma but were cytoplasmic in location and not induced compared to Barrett's mucosa. These observations were supported by mRNA studies where only Slug mRNA was shown to be over-expressed in adenocarcinoma and inversely correlated to E-cadherin expression. Overexpression of Slug in OE33 mediated E-cadherin repression and induced the mesenchymal markers vimentin and fibronectin.CONCLUSION: Progression to adenocarcinoma is associated with increased Slug expression and this may represent a mechanism of E-cadherin silencing. | Paras Jethwa Mushal Naqvi Robert G Hardy Neil A Hotchin Sally Roberts Robert Spychal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，7： | 24 |
| 2 | 利用基于扫描相机的荧光寿命成像显微技术研究细胞周期显示文摘利用基于扫描相机的荧光寿命成像显微系统,以细胞周期为模型,研究转染绿色荧光蛋白的HeLa细胞的荧光寿命。结果表明,处于周期内不同进程的细胞的荧光寿命为2.50-3.00 ns。处于分裂期的细胞的荧光寿命在1 h内从2.86 ns下降到2.82 ns;在DNA合成前期的8 h内,荧光寿命从2.82 ns下降到2.78 ns。荧光寿命的差异反映了细胞周期中核浆内大分子浓度的变化,对了解细胞周期的分子机制有一定的意义。 | 王岩 赵羚伶 陈同生 许改霞 Artem Pliss Tymish Y.Ohulchanskyy Paras N.Prasad 屈军乐 牛憨笨 | 2011 | 中国激光2011，38，3： | 7 |
| 3 | Inflammation and dry eye disease——where are we?显示文摘The presence of inflammation in dry eye disease(DED)results in increased patient symptomatology,ocular surface damage and worsening tear dysfunction.It also affects the health of meibomian glands and their secretions which further aggravates ocular surface disease.This article reviews current knowledge regarding ocular surface inflammation in DED and explores the relationships between the vicious cycles of DED,inflammation and meibomian gland dysfunction(MGD).The clinical evaluation of eyes with such changes,markers that identify the presence of inflammation on the ocular surface and current treatment options are discussed. | Srinivas K Rao Rishi Mohan Nikhil Gokhale Himanshu Matalia Paras Mehta | 2022 | International Journal of Ophthalmology(English edition)2022，15，5： | 4 |
| 4 | 生物相容性量子点的表征及其在细胞标记中的应用显示文摘利用无机低温水相合成法制备表面包覆L-半胱氨酸的CdTe/ZnTe核壳型量子点,测量不同溶液以及激发功率激光作用下该量子点的光谱特性。结果表明,该量子点吸收谱和荧光光谱峰值位置不随pH值变化,而荧光光强随pH值升高呈近似线性上升趋势;不同缓冲液对该量子点荧光光强无影响,但随孵育时间延长,荧光强度略有下降;在强激光照射下QDs会被快速光漂白,选择适当的激光功率(<100μW),可降低漂白速率,实现长时间稳定测量。因此,该量子点具有较好的生物稳定性和光稳定性,将其与血铁蛋白相连形成靶向共轭纳米粒,可成功用于HeLa细胞标记。细胞内量子点光漂白实验表明,细胞微环境会影响量子点的光稳定性,加速量子点的光漂白。 | 刘夏 陈丹妮 屈军乐 杨坚泰 罗永祥 Roy Indrajit 王晓梅 林晓潭 钟磊 Prasad N Paras 许改霞 牛憨笨 | 2010 | 光谱学与光谱分析2010，30，5： | 4 |
| 5 | Black phosphorus-based photothermal therapy with aCD47-mediated immune checkpoint blockade for enhanced cancer immunotherapy显示文摘Here,we describe a combination strategy of black phosphorus(BP)-based photothermal therapy together with anti-CD47 antibody(aCD47)-based immunotherapy to synergistically enhance cancer treatment.Tumour resistance to immune checkpoint blockades in most cancers due to immune escape from host surveillance,along with the initiation of metastasis through immunosuppressive cells in the tumour microenvironment,remains a significant challenge for cancer immunotherapy.aCD47,an agent for CD47/SIRPαaxis blockade,induces modest phagocytic activity and a low response rate for monotherapy,resulting in failures in clinical trials.We showed that BP-mediated ablation of tumours through photothermal effects could serve as an effective strategy for specific immunological stimulation,improving the inherently poor immunogenicity of tumours,which is particularly useful for enhancing cancer immunotherapy.BP in combination with aCD47 blockade activates both innate and adaptive immunities and promotes local and systemic anticancer immune responses,thus offering a synergistically enhanced effect in suppression of tumour progression and in inducing abscopal effects for inhibition of metastatic cancers.Our combination strategy provides a promising platform in which photothermal agents could help to enhance the therapeutic efficacy of immunotherapy. | Zhongjian Xie Minhua Peng Ruitao Lu Xiangying Meng Weiyuan Liang Zhongjun Li Meng Qiu Bin Zhang Guohui Nie Ni Xie Han Zhang Paras N.Prasad | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 6 | Hot-band absorption of indocyanine green for advanced anti-stokes fluorescence bioimaging显示文摘Bright anti-Stokes fluorescence(ASF)in the first near-infrared spectral region(NIR-I,800 nm–900 nm)under the excitation of a 915 nm continuous wave(CW)laser,is observed in Indocyanine Green(ICG),a dye approved by the Food and Drug Administration for clinical use.The dependence of fluorescence intensity on excitation light power and temperature,together with fluorescence lifetime measurement,establish this ASF to be originated from absorption from a thermally excited vibrational level(hot-band absorption),as shown in our experiments,which is stronger than the upconversion fluorescence from widely-used rare-earth ion doped nanoparticles.To test the utility of this ASF NIR-I probe for advanced bioimaging,we successively apply it for biothermal sensing,cerebral blood vessel tomography and blood stream velocimetry.Moreover,in combination with L1057 nanoparticles,which absorb the ASF of ICG and emit beyond 1100 nm,these two probes generate multi-mode images in two fluorescent channels under the excitation of a single 915 nm CW laser.One channel is used to monitor two overlapping organs,urinary system&blood vessel of a live mouse,while the other shows urinary system only.Using in intraoperative real-time monitoring,such multi-mode imaging method can be beneficial for visual guiding in anatomy of the urinary system to avoid any accidental injury to the surrounding blood vessels during surgery. | Jing Zhou Xiaoxiao Fan Di Wu Jie Liu Yuhuang Zhang Zikang Ye Dingwei Xue Mubin He Liang Zhu Zhe Feng Andrey N.Kuzmin Wen Liu Paras N.Prasad Jun Qian | 2021 | Light(Science & Applications)2021，10，10： | 3 |
| 7 | Automated Identification Algorithm Using CNN for Computer Vision in Smart Refrigerators显示文摘Machine Learning has evolved with a variety of algorithms to enable state-of-the-art computer vision applications.In particular the need for automating the process of real-time food item identification,there is a huge surge of research so as to make smarter refrigerators.According to a survey by the Food and Agriculture Organization of the United Nations(FAO),it has been found that 1.3 billion tons of food is wasted by consumers around the world due to either food spoilage or expiry and a large amount of food is wasted from homes and restaurants itself.Smart refrigerators have been very successful in playing a pivotal role in mitigating this problem of food wastage.But a major issue is the high cost of available smart refrigerators and the lack of accurate design algorithms which can help achieve computer vision in any ordinary refrigerator.To address these issues,this work proposes an automated identification algorithm for computer vision in smart refrigerators using InceptionV3 and MobileNet Convolutional Neural Network(CNN)architectures.The designed module and algorithm have been elaborated in detail and are considerably evaluated for its accuracy using test images on standard fruits and vegetable datasets.A total of eight test cases are considered with accuracy and training time as the performance metric.In the end,real-time testing results are also presented which validates the system’s performance. | Pulkit Jain Paras Chawla Mehedi Masud Shubham Mahajan Amit Kant Pandit | 2022 | Computers, Materials & Continua2022，，5： | 2 |
| 8 | Graphene–aluminum nanocomposites显示文摘 | Stephen F. Bartolucci Joseph Paras Mohammad A. Rafiee Javad Rafiee Sabrina Lee Deepak Kapoor Nikhil Koratkar | 2011 | Materials Science & Engineering A2011，，27： | 2 |
| 9 | Concentration versus non-concentrating reactors for solar photocatalytic degradation of p - nitrotoluene - o - sulfonic 显示文摘 | Para S malato S Blanco J | 2001 | Wat Sci Technol2001，44，5： | 2 |
| 10 | Effect of sand roasting and microwave cooking on antioxidant activity of barley显示文摘 | Paras Sharma Hardeep Singh Gujral | 2010 | Food Research International2010，，1： | 2 |
| 11 | Converting ceria polyhedral nanoparticles into single-crystal nanospheres 显示文摘 | Feng X D Sayle D C Wang Z L Paras M S Santora B Sutorik A C Sayle T X T Yang Y Ding Y Wang X D Her Y S | 2006 | Science2006，312，5779： | 1 |
| 12 | Guidelines on diabetes, pre-diabetes, and cardiovascular diseases 显示文摘 | GRUPO DE TRABAJO SOBRE DIABETES Y ENFERMEDADES CARDIOVASCULARES DE LA SOCIEDAD EUROPEA DE CARDIOLOGIA Y DE LA SOCIEDAD EUROPEA PARA EL ESTUDIO DE LA DIABETES RYDEN L STANDL E | 2007 | Rev Esp Cardiol (西班牙文)2007，60，5： | 1 |
| 13 | A Comprehensive Method for Piston Secondary Dynamics and Piston-Bore Contact显示文摘 | Prashant Patel Zissimos P Mourelatos Paras Shah | 2007 | SAE paper2007，，： | 1 |
| 14 | A novel approach to forecast electricity price for PJM using neural network and similar days method显示文摘 | PARAS M TOMONOBU S NAOMITSU U | 2007 | IEEE Transactions on Power Systems2007，22，4： | 1 |
| 15 | Prediction trends in rate parameters for self-diffusion on FCC metal surfaces显示文摘 | Agrawal Paras M Rice Besty M Thompson Donald L | 2002 | Surface Science2002，515，： | 1 |
| 16 | PRR3 Is a vascular regulator of TOCI stability in the Arabidopsis circadian clock 显示文摘 | PARA A FARRE E M IMAIZUMI T | 2007 | Plant Cell2007，19，11： | 1 |
| 17 | Risk factors of prolonged mechanicalventilation following open heart surgery:what has changed overthe last decade? 显示文摘 | Siddiqui MM Paras I Jalal A | 2012 | Cardiovascular Diagnosis and Therapy2012，2，3： | 1 |
| 18 | Surface activity of cationic surfactants, influence of molecular structure 显示文摘 | GRAZYNA PARA AGNIESZKA HAMERSKA - DUDRA KAZIMI- ERA ANNA WILK | 2010 | Colloids and Surfaces A:Physicochemical and Engineering Aspects2010，365，123： | 1 |
| 19 | Sol-gel-processed SiO2/TiO2/Poly (Vinylpyrrolidone) Composite Materials for Optical Waveguides显示文摘 | Makoto Yoshida Paras N Prasad | 1996 | Chem Mater1996，8，1： | 1 |
| 20 | Effect of liquid properties on the performance of bubble column reactors with fine pore spargers 显示文摘 | MOUZA A A DALAKOGLOU G K PARAS S V | 2005 | Chem Eng Sci2005，60，： | 1 |
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